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Receptor Regulation pp 67–81Cite as

Regulation of Prolactin Receptors in Target Cells

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Part of the book series: Receptors and Recognition ((WOCS))

Abstract

The diverse actions of prolactin have been reviewed by Bern and Nicoll (1968) and Horrobin (1978). Besides its well-known mammogenic role, prolactin is important in regulating the functions of many organs in many species. In the mammals, the mammary gland is undoubtedly one of the principal target organs of prolactin. In this tissue, prolactin is a lactogenic and a mitogenic hormone (Cowie and Tindal, 1971; Ceriani, 1974). The biological actions of prolactin in other organs such as liver, kidney and the reproductive organs are less well defined. Nevertheless, prolactin has been reported to stimulate somatomedin production (Francis and Hill, 1970) and ornithine decarboxylase activity in rat liver (Richards, 1975) and to affect kidney’s ability to retain Na+ ions (Nicoll, 1975). The luteotropic and luteolytic action in the ovary is well documented (Nicoll, 1975; Wuttke and Meites, 1971). Prolactin also stimulates prostatic growth (Moger and Geschwind, 1972) and uptake of testosterone by the prostate (Farnsworth, 1977).

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Authors
  1. Robert P. C. Shiu
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  2. Henry G. Friesen
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Editors and Affiliations

  1. Duke University Medical Center, Durham, North Carolina, USA

    R. J. Lefkowitz (Professor of Medicine) (Professor of Medicine)

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© 1981 Chapman and Hall

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Shiu, R.P.C., Friesen, H.G. (1981). Regulation of Prolactin Receptors in Target Cells. In: Lefkowitz, R.J. (eds) Receptor Regulation. Receptors and Recognition. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5822-7_4

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  • DOI: https://doi.org/10.1007/978-94-009-5822-7_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-5824-1

  • Online ISBN: 978-94-009-5822-7

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