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Adenosine as a Regulator of Adenylate Cyclase

  • Chapter
Purinergic Receptors

Abstract

The role of adenosine as a ‘local hormone’ has been firmly established in the past decade. Recently, several reviews have appeared on the numerous physiological effects of adenosine (Arch and Newsholme, 1978; Fox and Kelly, 1978) and on the various mechanisms of nucleoside metabolism, including phosphorylation, deamination, degradation (Arch and Newsholme, 1978; Fox and Kelly, 1978), and entry into the S-adenosyl homocysteine pathway (Usdin et al., 1979). Fain and Malbon (1979) have reviewed the evidence that links adenosine action at plasma membranes with cellular cyclic nucleotide metabolism. Burnstock (1979) has compared and contrasted the effects of adenosine and adenine nucleotides on various physiological systems. The conclusion derived from these reviews is that many, if not all, cells are subject to regulation by adenosine.

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Abbreviations

PIA:

N6 -phenylisopropyladenosine

NECA:

5′-N-ethylcarboxamideadenosine

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Authors
  1. Constantine Londos
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  2. J. Wolff
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  3. Dermot M. F. Cooper
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Editors and Affiliations

  1. Department of Anatomy and Embryology, University College London, UK

    G. Burnstock

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Londos, C., Wolff, J., Cooper, D.M.F. (1981). Adenosine as a Regulator of Adenylate Cyclase. In: Burnstock, G. (eds) Purinergic Receptors. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5816-6_8

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