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Sites of Action and Production of Adenosine in the Heart

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Book cover Purinergic Receptors

Abstract

The coronary-dilating action of adenosine and adenine nucleotides was first recognized by Drury and Szent-Györgyi (1929). These authors were also first to describe two additional effects of adenosine and AMP in the heart, namely the inhibition of impulse generation and conduction in the sinus and AV-node respectively, and the depression of contractile force in atrial muscle. In other early studies the action of adenosine on the sinus and the AV-node was shown to be species-dependent, lowering the frequency in cat, rabbit, rat and dog sinus node, and exerting its action in the guinea-pig heart primarily on the AV-node (for review see Drury, 1936).

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References

  • Afonso, S. (1970), Circulation Res., 26, 743–752.

    Google Scholar 

  • Afonso, S. and O’Brien, G.S. (1967), Circulation Res., 20, 403–408.

    Google Scholar 

  • Afonso, S., O’Brien, G.S. and Crumpton, C.W. (1968), Circulation Res., 22, 43–48.

    Google Scholar 

  • Angus, J.A., Cobbin, L.B., Einstein, K. and Maguire, (1971), Br. J. Pharmacol., 41, 592–593.

    Google Scholar 

  • Ariens, E.J. (1964), Molecular Pharmacol., Vol. 1, Academic Press, New York, pp. 1–462.

    Google Scholar 

  • Ariens, E.J., Simonis, A.M. and van Rossum, J.M. (1964), In: Molecular Pharmacology, Vol. 1, (Ariens, E.J., ed.), Academic Press, New York, pp. 287–393.

    Google Scholar 

  • Arnold, G., Kosche, F., Miessner, E., Neitzert, A. and Lochner, W. (1968), Pflügers Arch., 299, 339–356.

    Google Scholar 

  • Baer, H.P., Drummond, G.I. and Duncan, E.L. (1966), Mol. Pharmacol., 2, 67–76.

    Google Scholar 

  • Baumann, G., Schrader, J. and Gerlach, E., (1981), Circulation Res., in press.

    Google Scholar 

  • Belardinelli, L., Rubio, R. and Berne, R.M. (1979), Pflügers Arch., 380, 19–27.

    Google Scholar 

  • Belle, V.M. (1969), Biochim. biophys. Acta, 192, 124–132.

    Google Scholar 

  • Belloni, F.L. (1979), Cardiovas. Res., 13, 63–85.

    Google Scholar 

  • Berne, R.M. (1963), Am. J. Physiol., 204, 317–322.

    Google Scholar 

  • Berne, R.M., Foley, D.H., Watkinson, W.P., Miller, W.L., Winn, R. and Rubio, R. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, (Baer, H.P. and Drummond, G.I., eds.), Raven Press, New York

    Google Scholar 

  • Berne, R.M. and Rubio, R. (1973), In: Advances in Experimental Medicine and Biology, Vol. 39 (Blook, C.M. and Olsson, R.A., eds.), Plenum Press, New York. pp. 3–10.

    Google Scholar 

  • Bittar, N. and Pauly, T.J. (1971), Am. J. Physiol., 220, 812–815.

    Google Scholar 

  • Bohr, D.F. (1973), Circulation Res., 32, 665–672.

    Google Scholar 

  • Bohr, D.F. and Webb, R.C. (1978), In: Mechanisms of Vasodilatation, (Van Houtte, P.M. and Leusen, I., eds.), Karger, Basel, pp. 37–47.

    Google Scholar 

  • Borgers, M., Schaper, J. and Schaper, W. (1971), J. Histochem. Cytochem., 19, 526–539.

    Google Scholar 

  • Bretschneider, H.J., Frank, A., Bernhard, U., Kochsiek, K. and Scheler, F. (1959), Arzneimittel-Forsch., 9, 49–53.

    Google Scholar 

  • Buckley, N.M. (1970a), Am. J. Physiol., 218, 1399–1405.

    Google Scholar 

  • Buckley, N.M. (1970b), Arch. int. pharmacodyn. Thèr., 188, 92–104.

    Google Scholar 

  • Buckley, N.M., Tsuboi, K.K. and Zeig, N.N. (1959), Circulation Res., 7, 847–851.

    Google Scholar 

  • Buckley, N.M., Tsuboi, K.K. and Zeig, N.N. (1961), Circulation Res., 9, 242–249.

    Google Scholar 

  • Bunag, R.D., Douglas, C.R., Imai, S. and Berne, R.M. (1964), Circulation Res., 15, 83–88.

    Google Scholar 

  • Bünger, R., Haddy, F.J. and Gerlach, E. (1975), Pflügers Arch., 358, 213–224.

    Google Scholar 

  • Burger, R.M. and Lowenstein, J.M. (1970), J. biol. Chem., 245, 6274–6280.

    Google Scholar 

  • Burger, R.M. and Lowenstein, J.M. (1975), Biochemistry, 14, 2362–2366.

    Google Scholar 

  • Cobbin, L.B., Einstein, R. and Maguire, M.H. (1974), Br. J. Pharmacol., 50, 25–33.

    Google Scholar 

  • Cohen, M.L. and Berkowitz, B.A. (1974), J. Pharmacol. exp. Ther., 191, 147–155.

    Google Scholar 

  • Daniel, H.B., Bagwell, E.E. and Walton, R.P. (1967), Circulation Res., 21, 85–98.

    Google Scholar 

  • Davidson, S., Maroko, P.R. and Braunwald, E. (1974), Am. J. Physiol., 227, 439–443.

    Google Scholar 

  • Deuticke, B. and Gerlach, E. (1966), Naunyn Schmiederberg’s Arch. Pharmacol., 225, 107–119.

    Google Scholar 

  • Dobson, J.G. (1978), Circulation Res., 43, 785–792.

    Google Scholar 

  • Drummond, G.I. and Severson, D.L. (1979), Circulation Res., 44, 145–153.

    Google Scholar 

  • Drummond, G.I. and Yamamoto, M. (1971), Enzymes, 3rd edn., Vol. 4, pp. 337–352.

    Google Scholar 

  • Drury, A.N. (1936), Physiol. Rev., 16, 292–325.

    Google Scholar 

  • Drury, A.N. and Szent-Györgyi, A. (1929), J. Physiol., 68, 213.

    Google Scholar 

  • Endoh, M. and Yamashita, S. (1980) Europ. J. Pharmacol., 65, 445–448.

    Google Scholar 

  • Enero, M.A. and Saidman, B.Q. (1977), Naunyn Schmiederberg’s Arch. Pharmacol., 297, 39–46.

    Google Scholar 

  • Fain, J.N., Pointer, R.H. and Ward, W.F. (1972), J. biol. Chem., 284, 6866–6872.

    Google Scholar 

  • Filo, R.S., Bohr, D.F. and Ruegg, J.C. (1965), Science, 147, 1581–1583.

    Google Scholar 

  • Foley, D.H., Amsterdam, E.A. and Mason, D.T. (1979), Circulation Res., 44, 207–215.

    Google Scholar 

  • Fox, I.H. and Kelly, W.N. (1978), Am. Rev. Biochem., 47, 655–686.

    Google Scholar 

  • Frick, G.P. and Lowenstein, J.M. (1976), J. biol. Chem., 251, 6372–6378.

    Google Scholar 

  • Frick, G.P. and Lowenstein, J.M. (1978), J. biol. Chem., 253, 1240–1244.

    Google Scholar 

  • Gangjee, A., Hogenkamp, H.P.C. and Kitzen, J.M. (1978), J. Pharmacol. Sci., 67, 121–123.

    Google Scholar 

  • Gellai, M., Norton, J.M. and Detar, R. (1973), Circulation Res., 32, 279–289.

    Google Scholar 

  • Gerlach, E., Deuticke, B. and Dreisbach, R.H. (1963a), Naturwissenschaften, 50, 228–229.

    Google Scholar 

  • Gerlach, E. and Deuticke, G. (1963b), Arzneim. Forsch., 13, 48–50.

    Google Scholar 

  • Gerlach, E., Schrader, J. and Nees, S. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, (Baer, H.P. and Drummond, G.I., eds.), Raven Press, New York, pp. 127–136.

    Google Scholar 

  • Goto, M., Yatani, A. and Tsuda, Y. (1977), Jap. J. Physiol., 27, 81–94.

    Google Scholar 

  • Goto, M., Yatani, A. and Tsuda, Y. (1978), Jap. J. Physiol., 28, 611–625.

    Google Scholar 

  • Grossman, A. and Furchgott, R.F. (1964), J. Pharmacol., exp. Therap., 145, 162–172.

    Google Scholar 

  • de Gubareff, T. and Sleator, W. (1965), J. Pharmacol. exp. Ther., 148, 202–214.

    Google Scholar 

  • Guthrie, J.R. and Nayler, W.G. (1967), Arch. int. Pharmacodyn., 170, 249–255.

    Google Scholar 

  • de la Haba, G. and Cantoni, G.L. (1959), J. biol. Chem., 234, 603–608.

    Google Scholar 

  • Halloran, M.J. and Parker, C.W. (1966), J. Immunol., 96, 373–385.

    Google Scholar 

  • Harder, D., Belardinelli, L., Sperelakis, N., Rubio, R. and Berne, R.M. (1979), Circulation Res., 44, 176–182.

    Google Scholar 

  • van Harn, G.L., Rubio, R. and Berne, R.M. (1977), Am. J. Physiol., 233(2), 299–304.

    Google Scholar 

  • Hedqvist, P. and Fredholm, B.B. (1976), Naunyn Schmiedeberg’s Arch. Pharmacol., 293, 217–223.

    Google Scholar 

  • Hedqvist, P. and Fredholm, B.B. (1979), Acta physiol. scand., 105, 120–122.

    Google Scholar 

  • Henderson, J.F. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, Raven Press, New York, pp. 315–322.

    Google Scholar 

  • Herlihy, J.T., Bookman, E.L., Berne, R.M. and Rubio, R. (1976), Am. J. Physiol., 230, 1239–1243.

    Google Scholar 

  • Hilgemann, D., Englert, R. and Mensing, H.J. (1977), Experientia, 33, 1629–1631.

    Google Scholar 

  • Hockerts, T. and Bögelmann, G. (1959), Arzneim. Forsch., 9, 47–49.

    Google Scholar 

  • Hollander, P.B. and Webb, J.L. (1957), Circulation Res., 5, 349–553.

    Google Scholar 

  • Hopkins, S.V. (1973), Bio chem. Pharmacol., 22, 341–348.

    Google Scholar 

  • Hopkins, S.V. and Goldie, R.G. (1971), Biochem. Pharmacol., 20, 3359–3365.

    Google Scholar 

  • Huang, M. and Drummond, G.J. (1976), Biochem. Pharmacol., 25, 2713–2719.

    Google Scholar 

  • Jesmok, G.J., Gross, G.J. and Hardman, H.F. (1978), J. mol. cell Cardiol., 10, 249–261.

    Google Scholar 

  • Johnson, E.A. and McKinnon, M.G. (1956), Nature, 178, 1174–1175.

    Google Scholar 

  • de Jong, J.W. (1972), Biochim. biophys. Acta, 286, 252–259.

    Google Scholar 

  • Josephson, J., Renaus, J.F., Vogel, S., McLean, M. and Sperelakis, N. (1976), Eur. J. Pharmacol., 35, 393–398.

    Google Scholar 

  • Juhran, W. and Dietmann, K. (1970), Pflügers Arch., 315, 105–109.

    Google Scholar 

  • Kalsner, S. (1975), Br. J. Pharmacol., 55, 439–445.

    Google Scholar 

  • Klein, J. and Levey, G.S. (1971), J. clin. Invest., 50, 1012–1015.

    Google Scholar 

  • Kolassa, N., Pfleger, K. and Rummel, W. (1970), Eur. J. Pharmacol., 9, 265–268.

    Google Scholar 

  • Koss, F.W., Beisenherz, G. and Maerkisch, R. (1962), Arzneim. Forsch., 12, 1130–1131.

    Google Scholar 

  • Kraupp, O. (1969), Naunyn Schmiedeberg’s Arch. Pharmacol., 263, 144–155.

    Google Scholar 

  • Kredich, M., Hershfield, M.S. and Johnston, J.M. (1979), In: Transmethylation, (Usdin, E., Borchardt, R.T. and Creveling, C.R., eds.), Elsevier, North-Holland, pp. 225–230.

    Google Scholar 

  • Kukovetz, W.R., Wurm, A., Holzmann, S., Pöch, C. and Rinner, I. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, (Baer, H.P. and Drummond, G.I., eds.), Raven Press, New York, pp. 205–213.

    Google Scholar 

  • Kulkarni, D.S. and Saraf, A.P. (1978), Ind. Heart J., 30, 220–223.

    Google Scholar 

  • Lammerant, J. and Becsei, I. (1973), J. Physiol., London, 229, 41–49.

    Google Scholar 

  • Lammerant, J., Bescei, I., Mertens-Strijthagen, J. and de Schryver, C. (1970), Arch. int. pharmacodyn. Ther., 186, 166–178.

    Google Scholar 

  • Lefkowitz, R.J. (1975), J. biol. Chem., 250, 1006–1011.

    Google Scholar 

  • Levey, G.S. (1970), Biochem. biophys. Res. Com., 38, 86–92.

    Google Scholar 

  • Londos, C., Cooper, D.M.F., Schlegel, W. and Rodbell, M. (1978), Proc. natn. Acad. Sci., U.S.A., 75, 5362–5366.

    Google Scholar 

  • Londos, C. and Preston, M.S. (1977), J. biol. Chem., 252, 5951–5956.

    Google Scholar 

  • Londos, C. and Wolff, J. (1911), Proc. natn. Acad. Sci., U.S.A., 74, 5482–5486.

    Google Scholar 

  • McKenzie, S.G., Frew, R. and Baer, H.P. (1977), Eur. J. Pharmacol., 41, 193–203.

    Google Scholar 

  • Mahler, J.T., Manchanda, S.C., Cymeran, A., Wolfe, D.L. and Hartley, L.H. (1975), Am. J. Physiol., 228, 477–481.

    Google Scholar 

  • Merrill, G.F., Haddy, F.J. and Dabney, J.M. (1978), Circulation Res., 42, 225–229.

    Google Scholar 

  • Moir, T.W. and Downs, T.D. (1972), Am. J. Physiol., 222, 1386–1390.

    Google Scholar 

  • Moir, T.W. and Downs, T.D. (1973), Proc. Soc. exp. Biol. Med., 144, 517–522.

    Google Scholar 

  • Nakatsu, K. and Drummond, G.I. (1972), Am. J. Physiol., 223, 1119–1127.

    Google Scholar 

  • Namm, D.H. (1973), Circulation Res., 33, 686–695.

    Google Scholar 

  • Nees, S., Willershausen-Zönnchen, B. and Gerlach, E. (1979), Pflügers Arch., 379, R 6.

    Google Scholar 

  • Olsson, R.A., Davis, C.J. and Khouri, E.M. (1978), Life Sci., 21, 1343–1350.

    Google Scholar 

  • Olsson, R.A., Davis, C.J., Khouri, E.M. and Patterson, R. (1976), Circulation Res., 39, 93–98.

    Google Scholar 

  • Olsson, R.A., Gentry, M.K. and Snow, J.A. (1973), Biochem. biophys. Acta, 311, 242–250.

    Google Scholar 

  • Olsson, R.A., Khouri, E.M., Bedynek, J.L. and McLean, J. (1979), Circulation Res., 45, 468–478.

    Google Scholar 

  • Olsson, P.A. and Patterson, R.E. (1916), Prog, molec. subcel. Biol., 4, 227–248.

    Google Scholar 

  • Paddle, B.M. and Burnstock, G. (1974), Blood Vessels, 11, 110–119.

    Google Scholar 

  • Pappano, A.J. (1970), Circulation Res., 27, 379–390.

    Google Scholar 

  • Paterson, A.R.P. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, (Baer, H.P. and Drummond, G.I., eds.), Raven Press, New York, pp. 305–313.

    Google Scholar 

  • Pfleger, K., Volkmer, I. and Kolassa, N. (1969), Arzneim. Forsch., 19, 1972–1974.

    Google Scholar 

  • Raberger, G. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, (Baer, H.P. and Drummond, G.I., eds.), Raven Press, New York, pp. 155–166.

    Google Scholar 

  • Raberger, G., Kraup, O., Stuhlinger, W., Nell, G. and Chirikdjian, J.J. (1970), Pflügers Arch., 317, 20–34.

    Google Scholar 

  • Raberger, G., Weissel, M. and Kraupp, O. (1911), Naunyn Schmiedeberg’s Arch. Pharmacol., 271, 301–310.

    Google Scholar 

  • Rand, M. and Stafford, A. (1957), Arch. int. Pharmacodyn., 109, 425–437.

    Google Scholar 

  • Reuter, H. (1979), Ann. Rev. Physiol., 41, 413–424.

    Google Scholar 

  • Reuter, H. and Scholz, H. (1977), J. Physiol., London, 264, 49–62.

    Google Scholar 

  • Rickli, E.E., Ghazanfar, S.A.S., Ginnons, B.H. and Edsall, I.I. (1964), J. biol. Chem., 239, 1065–1078.

    Google Scholar 

  • Rockoff, J.B. and Dobson, J.G. (1979), Fed. Proc, 38, 975.

    Google Scholar 

  • Rodbell, M. (1979), Nat. Cancer Inst. Monogr., 48, 271–276.

    Google Scholar 

  • Rubio, R., Belardinelli, L., Thompson, C.I. and Berne, R.M. (1979), In: Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides, Raven Press, New York, pp. 167–182.

    Google Scholar 

  • Rubio, R., Berne, R.M. and Dobson, J.G. (1973), Am. J. Physiol., 225, 938–953.

    Google Scholar 

  • Rubio, R., Wiedmeier, V.T. and Berne, R.M. (1912), Am. J. Physiol., 222, 5550–5555.

    Google Scholar 

  • Schaumann, W., Juhran, W. and Dietmann, K. (1970), Arzneim. Forsch., 20, 372–377.

    Google Scholar 

  • Schnaar, R.L. and Sparks, H.V. (1972), Am. J. Physiol., 223, 223–228.

    Google Scholar 

  • Scholtholt, J., Nitz, R.E. and Schraven, E. (1972), Arzneim. Forsch., 22, 1255–1259.

    Google Scholar 

  • Schrader, J., Baumann, G. and Gerlach, E. (1977a), Pflügers Arch., 372, 29–35.

    Google Scholar 

  • Schrader, J. and Gerlach, E. (1976), Pflügers Arch., 367, 129–131.

    Google Scholar 

  • Schrader, J., Haddy, F.J. and Gerlach, E. (1977b), Pflügers Arch., 369, 1–6.

    Google Scholar 

  • Schrader, J., Nees, S. and Gerlach, E. (1977c), Pflügers Arch., 369, 251–257.

    Google Scholar 

  • Schrader, J., Rubio, R. and Berne, R.M. (1975), J. mol. cell Cardiol., 7, 427–433.

    Google Scholar 

  • Schrader, J. and Schütz, W. (1979), Fedn. Proc., Fedn. Am. Socs. exp. Biol., 38, 4279.

    Google Scholar 

  • Schrader, J., Schütz, W. and Bardenheier, H. (1981), Biochem. J., in press.

    Google Scholar 

  • Schütz, W., Schrader, J. and Gerlach, E. (1981), submitted for publication.

    Google Scholar 

  • Schwabe, U., Ebert, R. and Erbler, H.C. (1975), Adv. cyclic nucleotide Res., 5, 569–584.

    Google Scholar 

  • Shah, A., Kechejian, S.J., Kaveler, F. and Fisher, V.J. (1974), Am. Heart J., 76, 740–749.

    Google Scholar 

  • Somlyo, A.P. (1978), In: Mechanisms of Vasodilatation, (Vanhoutte, P.M. and Leusen, I., eds.), Karger, Basel, pp. 21–29.

    Google Scholar 

  • Sonnenschein, R.R., Wright, D.L. and Mellander, S. (1967), Am. J. Physiol., 213, 706–710.

    Google Scholar 

  • Spieckermann, P.G., Hellberg, K., Kettler, D., Reploh, H.D. and Strauer, B. (1969), Pflügers Arch., 312, R 15.

    Google Scholar 

  • Stafford, A. (1966), Br. J. Pharmacol., 28, 218–227.

    Google Scholar 

  • Stein, H.H. and Somani, P. (1975), Ann. N.Y. Acad. Sci., 255, 380–387.

    Google Scholar 

  • Sundaralingam, M. (1975), Ann. N.Y. Acad. Sci., 255, 3–43.

    Google Scholar 

  • Thyrum, P.T. (1974), J. Pharmacol. exp. Therap., 188, 166–179.

    Google Scholar 

  • Triner, L., Nahas, G.G. Vulliemox, Y., Overweg, N.I.A., Verosky, M., Habif, D.V. and Ngai, S.H. (1971), Ann. N.Y. Acad. Sci., 185, 458–476.

    Google Scholar 

  • Turnheim, K., Pittner, H., Kolassa, N. and Kraupp, O. (1977), Eur. J. Pharmacol., 41, 217–220.

    Google Scholar 

  • Ventner, J.C., Dixon, J.E., Maroko, P.R. and Kaplan, N. (1972), Proc. nat. Acad. Sci., U.S.A., 69, 1141–1145.

    Google Scholar 

  • Ventner, J.C., Ross, J., Dixon, J.E., Mayer, S.E. and Kaplan, N.O. (1973), Proc. natn. Acad. Sci., U.S.A., 70, 1214–1217.

    Google Scholar 

  • Verhaege, R.H. (1977), Am. J. Physiol., 233, 114–121.

    Google Scholar 

  • Verhaege, R.H., Vanhoutte, P.M. and Shephard, J.T. (1977), Circulation Res., 40, 208–215.

    Google Scholar 

  • Westfall, T.C. and Hunter, P.E. (1974), J. Pharm. Pharmacol., 26, 458–460.

    Google Scholar 

  • Wiedmeier, V.T., Rubio, R. and Berne, R.M. (1972), Am. J. Physiol., 223, 551–554.

    Google Scholar 

  • Wolf, M.A. and Berne, R.M. (1956), Circulation Res., 4, 343–348.

    Google Scholar 

  • Wolff, J., Londos, C. and Cook, G.H. (1978), Arch. biochem. Biophys., 191, 161–168.

    Google Scholar 

  • Yatani, A., Goto, M. and Tsuda, Y. (1978), Jap. J. Physiol., 28, 47–61.

    Google Scholar 

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  1. Department of Anatomy and Embryology, University College London, UK

    G. Burnstock

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Schrader, J. (1981). Sites of Action and Production of Adenosine in the Heart. In: Burnstock, G. (eds) Purinergic Receptors. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5816-6_4

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