Abstract
The previous chapter has outlined the sources of selectivity which are available for controlling uneconomic cells. Before these principles are discussed in depth, a brief account must be given of what is known of the molecular basis for biological activity in a foreign substance. This activity can usefully be viewed as a primary force which knowledge of selectivity can tame in the service of man.
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Suggestions for further reading
Albert, A. (1973), Selective Toxicity, 5th. edn., Chapman and Hall, London, 597 pp. This deals with all the topics discussed in this chapter, but in greater depth.
Porter, C.C. (1970), Chemical Mechanisms of Drug Action, Charles C. Thomas, Springfield, U.S.A., 165 pp. A selection of topics related to drug action, with particular emphasis on biopolymers.
Gale, E.F., Cundliffe, E., Reynolds, P.E., Richmond, M.H., and Waring M.J. (1972). The Molecular Basis of Antibiotic Action, Wiley, London, 456 pp. Five authors, with considerable experience inthis field, discuss the title subject.
Goldstein, A., Aronow, L., and Kaiman, S.M., (1974), Principles of Drug Action, Wiley, New York, 884 pp. A pharmacological presentation of materialdiscussed in this chapter and the next, with further related topics.
Ariëns, E.J. (editor) (1971-2), Drug Design, Academic Press, New York (vols 1-3). A series of essays on the rational approach tothe design and development of biologically active substances.
Some annuals: Advances in Drug Research (Academic Press), Progress in Medicinal Chemistry (Butterworths), Medicinal Chemistry (Wiley), Annual Reports in Medicinal Chemistry (Academic Press) (these last two volumes are sponsored by the Division of Medicinal Chemistry of the American Chemical Society), Annual Review of Pharmacology (Annual Reviews, Inc., California), Pharmacological Reviews (American Society of Pharmacologists), Fortschritte der Arzneimittelforschung, (Birkhäuser, Basel).
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Albert, A. (1975). Steps in the correlation of structure with biological activity. In: The Selectivity of Drugs. Outline Studies in Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5734-3_3
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DOI: https://doi.org/10.1007/978-94-009-5734-3_3
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