Abstract
Physiologic data provide abundant documentation for the blood pressure regulatory role of the renin-angiotensin system to be exercised through its capacity for altering the levels of circulating angiotensin II [22, 7, 13]. Although angiotensin II is the only product of this system that has a direct vasoconstrictor effect and should correlate directly with blood pressure readings, its measurement is more difficult than the measurement of renin activity, and hence data on that correlation are limited [22, 4, 2]. Plasma renin activity is the variable component of this regulatory system most often measured, and from this single determination inferences are made about the physiologic state of the renin-angiotensin system and indirectly about the level of circulating angiotensin II [3, 25, 8]. In fact, several components of the renin-angiotensin system may exert an important and variable influence upon the rate of angiotensin II production and upon plasma angiotensin II concentrations.
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© 1984 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster
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Walker, W.G., Saito, H. (1984). The Relation of Plasma Renin Substrate to Blood Pressure in Essential Hypertension. In: Sambhi, M.P. (eds) Fundamental Fault in Hypertension. Developments in Cardiovascular Medicine, vol 36. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5678-0_25
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DOI: https://doi.org/10.1007/978-94-009-5678-0_25
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