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Is there a Fault in the Renin-Angiotensin System in Essential Hypertension?

  • Chapter
Fundamental Fault in Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 36))

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Abstract

I should admit, first of all, that the concept of a ‘fault’ in any system in essential hypertension worries me. Recognition of a fault implies that some individuals have that fault and others do not. This seems to be dangerously close to the heresy that held that hypertension was a discrete disease — a view so thoroughly refuted by Pickering [22]. Elevated blood pressure is like tallness, obesity, and an extrovert personality — a quantitative deviation from the norm. We are no more successful in finding a cause for high blood pressure in most hypertensive patients than we are in discovering a cause for a particular body stature or personality. In each case we are observing a constitutional quality that is determined multifactorially; we are particularly interested in hypertension because that quality is harmful to health and survival. If it were not, I strongly suspect that most of us would accept high blood pressure as part of a biological spectrum. Because hypertension has discrete consequences — strokes and heart attacks — we erroneously think of it as a discrete disease.

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Authors
  1. John D. Swales
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Editors and Affiliations

  1. Division of Hypertension, Department of Medicine, UCLA, Sepulveda, CA, USA

    Mohinder P. Sambhi MD, PhD (Professor and Chief) (Professor and Chief)

  2. San Fernando Valley Medical Program, Veterans Administration Medical Center, Sepulveda, CA, USA

    Mohinder P. Sambhi MD, PhD (Professor and Chief) (Professor and Chief)

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© 1984 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster

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Swales, J.D. (1984). Is there a Fault in the Renin-Angiotensin System in Essential Hypertension?. In: Sambhi, M.P. (eds) Fundamental Fault in Hypertension. Developments in Cardiovascular Medicine, vol 36. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5678-0_23

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  • DOI: https://doi.org/10.1007/978-94-009-5678-0_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9006-3

  • Online ISBN: 978-94-009-5678-0

  • eBook Packages: Springer Book Archive

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