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Possible Mechanism of Protection from Renal Hypertension by Anteroventral Third Ventricle (AV3V) Lesions: Role of Renal Afferent Nerves

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Fundamental Fault in Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 36))

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Summary

Regional hemodynamic responses produced by renal afferent nerve stimulation (RANS) in rats are described. There responses were qualitatively similar to those produced by direct stimulation of the anteroventral third ventricle (AV3V).

A lesion of the AV3V, previously shown to prevent renal and mineralocorticoid hypertension, abolished the responses to RANS.

Deafferentation of the kidney by autotransplantation (AT) delayed the appearance of one-kidney (1-K) Grollman hypertension for two months. In contrast, AT did not affect the course of blood pressure elevation produced by deoxycorticosterone and salt (DOC-S).

These data suggest that renal afferent nerves, interacting with the region of the AV3V, may have a major role in the onset of 1-K Grollman hypertension, but do not appear to be involved in the pathogenesis of DOC-S hypertension.

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Authors
  1. L. T. Mahoney
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  2. J. R. Haywood
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  3. R. Correy
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  4. N. P. Patel
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  5. A. K. Johnson
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  6. M. J. Brody
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Editor information

Editors and Affiliations

  1. Division of Hypertension, Department of Medicine, UCLA, Sepulveda, CA, USA

    Mohinder P. Sambhi MD, PhD (Professor and Chief) (Professor and Chief)

  2. San Fernando Valley Medical Program, Veterans Administration Medical Center, Sepulveda, CA, USA

    Mohinder P. Sambhi MD, PhD (Professor and Chief) (Professor and Chief)

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© 1984 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster

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Mahoney, L.T., Haywood, J.R., Correy, R., Patel, N.P., Johnson, A.K., Brody, M.J. (1984). Possible Mechanism of Protection from Renal Hypertension by Anteroventral Third Ventricle (AV3V) Lesions: Role of Renal Afferent Nerves. In: Sambhi, M.P. (eds) Fundamental Fault in Hypertension. Developments in Cardiovascular Medicine, vol 36. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5678-0_15

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  • DOI: https://doi.org/10.1007/978-94-009-5678-0_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9006-3

  • Online ISBN: 978-94-009-5678-0

  • eBook Packages: Springer Book Archive

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