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Part of the book series: Developments in Nephrology ((DINE,volume 4))

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Abstract

The regulation of the renal excretion of Na plays a fundamental role in the regulation of ECF volume. Maintenance of a constant ECF volume requires a balanced state of intake and output. Under normal conditions — without abnormal losses in sweat or from the gut — the urinary excretion of Na corresponds to its intake.

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References

  • Barajas, L., Müller, J.: The innervation of the juxtaglomerular apparatus and surrounding tubules: A quantitative analysis by serial section electron microscopy. J. Ultrastruct. Res. 43: 107, 1973

    Article  PubMed  CAS  Google Scholar 

  • Bartter, F. C.: Clinical problems of potassium metabolism. Contr. Nephrol. 21: 115, 1980

    CAS  Google Scholar 

  • Barton, L. J., Lackner, H. L., Rector, F. C., Seldin, D. W.: The effect of volume expansion on sodium reabsorption in the diluting segment of the dog kidney. Kidney int. 1: 19, 1972

    Article  PubMed  CAS  Google Scholar 

  • Bello-Reuss, E., Trevino, P. L., Gottschalk, C. W.: Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption. J. clin. Invest. 57: 1104, 1976

    Article  Google Scholar 

  • Bennett, C. M.: Effect of extracellular volume expansion upon sodium reabsorption in the distal nephron of dogs. J. clin. Invest. 52: 2548, 1973

    Article  PubMed  CAS  Google Scholar 

  • Bourgoignie, J., Hwang, J., Ipaskehi, E., Bricker, N. S.: The presence of a natriuretic factor in urine of patients with chronic uremia. The absence of the factor in nephrotic uremic patients. J. clin Invest. 53: 1559, 1974

    Article  PubMed  CAS  Google Scholar 

  • Bricker, N. S., Klahr, S., Parkenson, M., Schultze, R. G.: Renal function in chronic renal disease. Medicine 44: 263, 1965

    Article  PubMed  CAS  Google Scholar 

  • Brunner, H., Kushinsky, G., Peters, G.: Die Wirkung von Vasopressin auf die renale Wasser- und Salzausscheidung der Ratte bei Veränderungen der Salzkonzentration des Trinkwassers und nach Nierenparenchymresektion. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmacol. 228: 434, 1956

    CAS  Google Scholar 

  • Cheek, D. B., Perry, J. W.: A salt wasting syndrome in infancy. Arch. Dis. Child. 33: 252, 1958

    Article  PubMed  CAS  Google Scholar 

  • Coleman, A. J., Arias, M., Carter, N. W., Rector, F. C. Jr., Seldin, D. W.: The mechanism of salt wastage in chronic renal disease. J. clin. Invest. 45: 1116, 1966

    Article  PubMed  CAS  Google Scholar 

  • Cort, J. H.: Electrolytes, fluid dynamics and the nervous system Prague. Publ. House Czechoslov. Acad. Sci. 1965

    Google Scholar 

  • Cort, J. H., Lichardus, B.: The natriuretic activity of jugular vein blood during carotid occlusion. Physiol. bohemoslov. 12: 497, 1963

    PubMed  CAS  Google Scholar 

  • Crabbé, J., Ross, E. J., Thorn, G. W.: The significance of the secretion of aldosterone during dietary sodium deprivation in normal subjects. J. clin. Endocrinol. Metabol. 18: 1159, 1958

    Article  Google Scholar 

  • Cove-Smith, J. R., Knapp, M. S.: Sodium handling in analgesic nephropathy. Lancet 2: 70, 1973

    Article  PubMed  CAS  Google Scholar 

  • Danowitch, G. M., Bricker, N. S.: Influence of volume expantion on NaCl reabsorption in the diluting segments of the nephron: A study using clearance methods. Kidney int. 10: 229, 1976

    Article  Google Scholar 

  • DeWardener, H., McGregor, G.: The natriuretic hormone and essential hypertension. In: Hormonal regulation of sodium excretion (Eds. B. Lichardus, R. W. Schrier and J. Ponec) Amsterdam Elsevier/North-Holland Biomed. Press 1980. pp. 387–392

    Google Scholar 

  • Deetjen, P., Kramer, K: Die Abhängigkeit des O2-Verbrauchs der Niere von der Na-Rückresorption. Pflüger’s Arch. ges. Physiol. 273: 636, 1961

    Article  CAS  Google Scholar 

  • DeWardener, H. E., Mills, I. H., Clapham, W. F., Hayter, C. J.: Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin. Sci. 21: 249, 1961

    CAS  Google Scholar 

  • DiBona, G. F.: Neurogenic regulation of renal tubular sodium reabsorption. Am. J. Physiol. 233: F 73, 1973

    Google Scholar 

  • Donnell, G. N., Litman, R., Roldan, M.: Pseudohypo-adrenalcorticism. Am. J. Dis. Child. 97: 813, 1959

    CAS  Google Scholar 

  • Edelman, I. S., Fimongari, G. M.: On the biochemical mechanism of action of aldosterone. Recent Progr. Horm. Res. 24: 1, 1968

    PubMed  CAS  Google Scholar 

  • Eknoyan, G., Suki, W. N., Rector, F. C., Seldin, D. W.: Functional characteristics of the diluting segment of the dog nephron and the effect of extracellular volume expansion on its reabsorptive capacity. J. clin. Invest. 46: 1178, 1967

    Article  PubMed  CAS  Google Scholar 

  • Favre, H.: An inhibitor of sodium transport in the urine of dogs and humans with normal renal function: A study of chronically expanded subjects. In: Natriuretic Hormone. Kramer, H. J., Krück, F. (Eds.) Berlin, Springer 1978, pp. 11–23

    Google Scholar 

  • Fejfar, Z., Fejfarová, M.: Hämodynamische Veränderungen der Kreislaufströmungen. Berlin Volk und Gesundheit 1961

    Google Scholar 

  • Fine, C. G., Bourgoignie, J. J., Hwank, K. H.: On the influence of the natriuretic factor from patients with chronic uremia on the bioelectric properties and sodium transport of its isolaetd mammalian collecting tubule. J. clin. Invest. 58: 590, 1976

    Article  PubMed  CAS  Google Scholar 

  • Gardner, K. D.: Evolution of clinical signs in adult-onset cystic disease of renal medulla. Ann. intern. Med. 74: 47, 1971

    PubMed  Google Scholar 

  • Gottschalk, C. W.: Renal nerves and sodium excretion. Ann. Rev. Physiol. 41: 229, 1979

    Article  CAS  Google Scholar 

  • Hamburger, J.: A reappraisal of the concept of organ rejection based on the study of homotransplanted kidneys. Transplantation 5: 870, 1967

    Article  PubMed  Google Scholar 

  • Hamburger, J., Richet, G., Crosnier, J., Funck-Bretano, J. L., Antoine, B., Durrot, H., Mery, J. P., DeMontera, H., Royer, P.: Nephrology. Co. Philadelphia, London, Toronto, W. B. Saunders 1968

    Google Scholar 

  • Herken, H., Senft, G., Schaper, J.: Die Beteiligung des Vasopressins an der Entstehungs des Ödems. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmacol. 230: 284, 1957

    CAS  Google Scholar 

  • Herzog, J. P., Johnston, H. H., Lauler, D. P.: Effects of prostaglandins E1 E2 and A1 on renal hemodynamics, sodium and water excretion in the dog. In: Prostaglandin Symposium of the Worcester Foundation for Experimental Biology, P. W. Ramwell, J. E. Shaw (Eds.). New York Interscience 1967 p. 147

    Google Scholar 

  • Hierholzer, K. M., Wiederholt, H., Holzgrene, G., Giebisch, R. M., Klose, E., Windhager, E. E.: Micropuncture study of renal transtubular concentration gradients of sodium and potassium in adrenalectomized rats. Pflüger’s Arch. ges. Physiol.285: 193, 1965

    Article  Google Scholar 

  • Jard, S. Morel, F.: Actions of vasotocin and some of its analogues on salt and water excretion by the frog. Am. J. Physiol. 204: 222, 1963

    CAS  Google Scholar 

  • Jirka, J.: Funkce ledvin při aktivním stoji a svalové námaze vleže u lidí se zdravými ledvinami a u nemocných chronickou glomerulonefritidou. Prague — Disseration thesis 1958

    Google Scholar 

  • Kagawa, C. M., Cella, J. A., van Arman, C. G.: Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science 126: 1015, 1957

    Article  PubMed  CAS  Google Scholar 

  • Kagawa, C. M., Sturlevant, F. M., van Arman, C. G.: Pharmacology of a new steroid that blocks salt activity of aldosterone and desoxycorticosterone. J. Pharmacol. exp. Ther. 126: 123, 1959

    PubMed  CAS  Google Scholar 

  • Kahn, T., Mohammad, G., Stein, R. M.: Alterations in renal tubular sodium and water reabsorption in chronic renal disease in man. Kidney int. 2: 164, 1972

    Article  PubMed  CAS  Google Scholar 

  • Landau, R. L., Bergenstal, D. M., Lugibihl Kascht, M. E.: The metabolic effects of progesterone in man. J. clin. Endocrinol. Metabol. 15: 1194, 1955

    Article  CAS  Google Scholar 

  • Lee, J. B., Covino, B. G., Takman, B. H., Smith, E. R.: Renomedullary vasodepressor substance, medullin: Isolation, chemical characterization and physiological properties. Circulat. Res. 27: 57, 1965

    Google Scholar 

  • Leutcher, J. A. Jr., Axelrod, B. J.: Increased aldosterone output during sodium deprivation in normal man. Proc. Soc. exp. Biol. Med. 87: 650, 1954

    Google Scholar 

  • Lichardus, B., Ponec, J.: Effect of hypophysectomy on sodium excretion in rats without blood dilution during blood volume expansion. Experientia 28: 471, 1972

    Article  PubMed  CAS  Google Scholar 

  • Lifschitz, M. D., Schrier, R. W., Edelman, I.: Effect of actinomycin D on aldosterone-mediated changes in electrolyte excretion. Am. J. Physiol. 224: 376, 1973

    PubMed  CAS  Google Scholar 

  • Martinez-Moldonado, M., Eknoyan, G., Suki, W. N.: Influence of volume expansion on renal diluting capacity in the rat. Clin. Sci. Mol. Med. 46: 331, 1974

    Google Scholar 

  • Miller, T. J., Anderson, R. J., Linas, S. L., Hendrick, W. L., Berns, A. S., Gabon, P. A., Schrier, R. W.: Urinary diagnostic indices in acute renal failure. A prospective study. Ann. intern. Med. 89: 47, 1978

    PubMed  CAS  Google Scholar 

  • Murphy, G. P., Hesse, V. E., Evers, J. L., Hobika, G., Mosteret, J., Szolnoky, A., Schoonees, P., Abramczyk, J., Grace, J. Jr.: The renal and cardiodynamic effects of prostaglandins (PGE1, PGA1) in renal ischemia. J. Surg. Res. 10: 533, 1970

    Article  PubMed  CAS  Google Scholar 

  • Platt, R.: Sodium and potassium excretion in chronic renal failure. Clin. Sci. 9: 367, 1950

    CAS  Google Scholar 

  • Platt, R.: Structural and functional adaptation in renal failure. Brit. med. J. 1: 1313, 1952

    Article  PubMed  CAS  Google Scholar 

  • Ramwell, P. W., Shaw, J. E.: Biological significance of the prostaglandins. Recent Progr. Hormone Res. 26: 139, 1970

    CAS  Google Scholar 

  • Rieder, J.: Physikalisch-chemische und biologische Untersuchungen an Sulfonamiden. Arzneimittelforschung 13: 81, 1963

    PubMed  CAS  Google Scholar 

  • Rösier, A., Theodor, R., Biochis, H., Gerty, R., Ulick, S., Alagem, M., Tabachnik, E., Cohen, B. Rabinowitz, D.: Metabolic responses to the administration of angiotensin II, K and ACTH in two salt-wasting syndromes. J. clin. Endocrinol. Metabol. 44: 292, 1977

    Article  Google Scholar 

  • Sebastian, A., McSherry, E., Morris, R. C.: Impaired renal conservation of sodium chloride during sustained correction of systemic acidosis in patients with Type I, classic renal tubular acidosis. J. clin. Invest. 58: 454, 1976

    Article  PubMed  CAS  Google Scholar 

  • Seldin, D. W., Rector, F. C.: Evaluation of clearance methods for localizatin of site of action of diuretics. In: Modern diuretic therapy in the treatment of cardiovascular and renal disease. Amsterdam, Excerpta Medica 1972, p. 97

    Google Scholar 

  • Schrier, R. W., DeWardener, H. E.: Tubular reabsorption of sodium ion influence of factors other than aldosterone and glomerular filtration rate. New Engl. J. Med. 285: 1231, 1971

    CAS  Google Scholar 

  • Schück, O.: Fractional sodium excretion in patients with chronic renal failure with respect to the therapy. Nephron 30: 95, 1982

    Article  PubMed  Google Scholar 

  • S chück, O., Stříbrná, J.: Renal clearance of sodium and solute-free water. Physiol. bohemoslov. 15: 210, 1966

    Google Scholar 

  • Sharp, G. W. G., Coggino, C. H., Lichtenstein, N. S., Leaf, A.: Evidence for a mucosal effect of aldosterone on sodium transport in the toad bladder. J. clin. Invest. 45: 1640, 1966

    Article  PubMed  CAS  Google Scholar 

  • Sharp, G. W. G., Leaf, A.: Studies on the biological action of aldosterone in vitro. J. clin. Invest. 42: 978, 1963

    Google Scholar 

  • Skou, J. C: The influence of some cations on adenosintriphosphatase from peripheral nerves. Bioch. biophys. Acta 23: 394, 1957

    Article  CAS  Google Scholar 

  • Slatopolsky, E., Elkan, I. O., Weerts, C., Bricker, N. S.: Studies on the characteristic of the control system governing sodium excretion in uremic man. J. clin. Invest. 47: 521, 1968

    Article  PubMed  CAS  Google Scholar 

  • Starzl, T. E.: Experience in renal transplantation. Philadelphia, Saunders 1964

    Google Scholar 

  • Stein, R. M., Abramson, R. G., Kahn, T., Levitt, M. F.: Effects of hypotonic saline loading in hydrated dog: Evidence for a saline induced limit on distal tubular sodium transport. J. clin. Invest. 46: 1205, 1967

    Article  PubMed  CAS  Google Scholar 

  • Strauss, M. B.: Clinical and pathological aspects of cystic disease of the renal medulla. Ann. intern. Med. 57: 373, 1962

    PubMed  CAS  Google Scholar 

  • Stříbrná, J., Růžičková, O., Schück, O., Firt, P., Dráb, K., Cholinský, K.: Changes in circadian sodium excretion in patients with essential hypertension and with renal artery stenosis. Cor Vasa 18: 11, 1976

    PubMed  Google Scholar 

  • Takacs, L., Benosath, P., Demeczky, L.: Renal sodium and water excretion after unilateral splanchnitocomy in the dog. Acta physiol. Acad. Sci Hung. 39: 289, 1971

    Google Scholar 

  • Takacs, L., Benosath, P., Szalay, L.: Depressed proximal tubular transport capacity after renal sympathectomy. Proc. VIIth int. Congr. Nephrol. Montreal 1978 Basel, Karger 1978, pp. 553–558

    Google Scholar 

  • Thurau, K.: Nature of autoregulation of renal blood flow. Proc. 3rd intern. Congr. Nephrol. Vol. 1 Basel, Karger New York 1967

    Google Scholar 

  • Ullrich, K. J.: Sugar, aminoacid and Na+ cotransport in the proximal tubule. Ann. Rev. Physiol. 41: 181, 1979

    Article  CAS  Google Scholar 

  • Ullrich, K. J.: Renal transport of sodium. Proc. 3rd Int. Congr. Nephrol. Vol. 1 Lasel, New York, Karger, 1966

    Google Scholar 

  • Vertel, R. M., Knochel, J. P.: Nonoliguric acute renal failure. J. am. med. Assoc. 200: 598, 1967

    Article  CAS  Google Scholar 

  • Wallin, J. D., Brennan, J. P., Long, D. L., Aronoff, S. L., Rector, F. C., Seldin, D. W.: Effect of increased distal bicarbonate delivery on free water reabsorption in the dog. Am. J. Physiol. 224: 209, 1973

    PubMed  CAS  Google Scholar 

  • Watt, B. K., Merrill, A. L.: In: Composition of foods. Raw. Processed. Prepared. Consumer and food economics Research Division. Agricultural research service. Washington United States Dept. of Agriculture, (revised ) 1963

    Google Scholar 

  • Wiederholt, M., Hierholzer, K., Rumrich, G., Holzgreve, H.: Transtubuläre Natriumströme im proximalen und distalen Tubulus adrenalektomierter Ratten. Pflüget’s Arch. ges. Physiol. 281: 95, 1964

    Google Scholar 

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© 1984 Martinus Nijhoff Publishers, Boston

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Schück, O. (1984). Excretion of Sodium. In: Examination of Kidney Function. Developments in Nephrology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5660-5_9

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  • DOI: https://doi.org/10.1007/978-94-009-5660-5_9

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