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Part of the book series: Developments in Nephrology ((DINE,volume 4))

Abstract

The relation between foam formation on the surface of urine and kidney disease was known by Hippocrates (cf. Cameron 1970). An actual demonstration of the presence of protein in the urine, however, had to wait until the dawn of scientific methods. Frederick Dekkers in 1673 started to use a heat coagulation test to demonstrate protein in the urine (cf. Free and Free 1975). The first physician to show clearly that patients with demonstrable anatomical pathology of the kidneys excreted an albuminous protein into the urine was Richard Bright (1836). Twelve years later Watson (cf.Snapper and Kahn 1971) and Bence-Jones (1848) described a quite different protein from that described by Bright in the urine. In 1878, Leube described proteinuria in soldiers after severe exercise, and in the same year Moxon described a postural stimulus to proteinuria (cf. Pesce and First 1979).

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References

  • Anderson, N. G., Anderson, N. L., Tollaksen, S. L.: Proteins in human urine: I. Concentration and analysis by two-dimensional electrophoresis. Clin. Chem. 25: 1199, 1979

    PubMed  CAS  Google Scholar 

  • Alt, J. M., Jänig, H., Schurek, H. J., Stolte, H.: Study of renal protein excretion in chronic pyelonephritis. Contr. Nephrol. 16: 37–43, 1979

    CAS  Google Scholar 

  • Antoine, B., Neven, Th.: Pathological urinary excretion of tissue macromolecules (histuria). J. lab. clin. Med. 71: 101, 1968

    PubMed  CAS  Google Scholar 

  • Balant, L., Fahre, J.: Clinical relevance of different electrophoretic methods for the analysis of urinary proteins. In: Current Problems in Clinical Biochemistry, vol. 9. U. C. Dubach, W, Schmidt (eds.), H. Bern, Huber, 1979

    Google Scholar 

  • Bence Jones, H.: On a new substance occurring in the urine of a patient with mollities ossium. Phil. Transac. Royal Soc. London, I., 1848

    Google Scholar 

  • Bennett, C. M., Glassock, R. J., Chang, R. L. S., Deen, W. M., Robertson, C. R., Brenner, B. M.: Permselectivity of the glomerular capillary wall: Studies of experimental glomerulonephritis in the rat using dextran sulfate. J. clin. Invest. 57: 1287, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Bergaard, I.: Studies on proteins, glycoproteins and mucopolysaccharides in normal human urine. Acta Soc. Med. Upps. 66: 230, 1961

    Google Scholar 

  • Bergaard, I.: Plasma protein in normal human urine. In: Proteins in normal and pathological urine. Y. Manuel, J. P. Rewillard (eds.) Basel Karger, 1970

    Google Scholar 

  • Bienenstock, G. M., Tomasi, T. B. Jr.: Sectory IgA in normal urine. J. clin. Invest. 47: 1162, 1968

    Article  PubMed  CAS  Google Scholar 

  • Bienenstock, J., Poortmans, J.: Renal clearance of 15 plasma proteins in renal disease. J. lab. clin. Med. 75: 297, 1970

    PubMed  CAS  Google Scholar 

  • Blainey, J. D., Brewer, D. B., Hardwicke, J.: Proteinuria and the nephrotic syndrome. In: Renal disease (Eds. D. Black and N. F. Jones). 4 ed. Oxford, Blackwell, 1979, pp. 383–399.

    Google Scholar 

  • Blainey, J. D., Brewer, D. B., Hardwicke, J., Soothill, J. F.: The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Quart. J. Med. 29: 23, 1960

    Google Scholar 

  • Boesken, W. H.: Disclelectrophoretic molecular weight analysis of urinary proteins. Contr. Nephrol. 1: 143, 1975

    CAS  Google Scholar 

  • Boesken, W. M.: Diagnostic significance of SDC-PAA electrophoresis of urinary proteins. In: Current Problems in Clin. Bioch., vol. 9. U. C. Dubach, W. Schmidt (eds.). Bern, H. Huber, 1979

    Google Scholar 

  • Bohrer, M. P., Baylis, C., Robertson, C. R., Brenner, B. M.: Mechanism of the puromycin-induced defects in the transglomerular passage of water and macromolecules. J. clin. Invest. 69: 152, 1977

    Article  Google Scholar 

  • Boileau, M., Fuchs, E., Barry, J. M., Hodges, C. V.: Stress haematuria: Athletic pseudonephritis in marathoners. Urology, 15: 471, 1980

    Article  PubMed  CAS  Google Scholar 

  • Karlsson, F. A., Wibell, L., Ervin, P. E.: Beta-2-microglobulin in clinical medicine. Scand. J. clin. lab. Invest 40 (suppl. 154): 27, 1980

    Google Scholar 

  • Kassirer, J. P., Gennari: Laboratory evaluation of renal function. In Strauss and Welt’s Diseases of the kidney. Third ed. (Eds. L. E. Early and. C. W. Gottschalk). pp 41–91. Boston, Little, Brown, 1979.

    Google Scholar 

  • King, J. S., Jr., Boyce, W. H., Little, J. M., Artom, C.: Total nondialyzable solids (TNDS) in human urine. I. The amount and composition of TNDS from normal subjects. J. clin. Invest. 37: 315, 1958

    Article  PubMed  CAS  Google Scholar 

  • Leskovar, P., Kratzer, M.: Electrophoretische Erfassung der einzelnen Harnproteinfraktionen. Med. Welt, 30: 47, 1777, 1979

    PubMed  CAS  Google Scholar 

  • Maack, T. M., Sherman, R. L.: Proteinuria. Am. J. Med. 56: 71, 1974

    Article  PubMed  Google Scholar 

  • Maack, T., Johnson, V. Kau, S. T. et al.: Renal filtration, transport and metabolism of low molecular-weight proteins. A review. Kidney. int. 16: 251, 1979

    Article  CAS  Google Scholar 

  • MacLean, P. R., Robson, J. S.: A simple method for determining selectivity of proteinuria. Lancet I: 539, 1967

    Google Scholar 

  • Maldonado, J. E., Velosa, J. A., Kyle, R. A., Wagoner, R. D., Holley, K. E., Salasa, R. M.: Fanconi syndrome in adults: A manifestation of a latent form of myeloma. Am. J. Med. 58: 354, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Mannuel, Y., Revillard, J. P.: Study of urinary proteins by zone electrophoresis. In: Proteins in normal and pathological urine. Mannuel Y., Revillard, J. P., Betiel, H. (eds.) S. Karger, Basel 1970, pp. 153–171

    Google Scholar 

  • Mannuel, Y., Colle, A., Leclercq, M., Tonnelle, C.: Low molecular weight proteinuria. Contr. Nephrol. 1: 156, 1975

    Google Scholar 

  • Misra, R. P., Berman, L. B.: The molecular basis of proteinuria. JAMA 242: 757, 1979

    Article  PubMed  CAS  Google Scholar 

  • Mogensen, C. E., Vittinghus, E., Soiling, K.: Abnormal albumin excretion after two provocative renal tests in diabetics: physical exercise and lysine injection. Kidney int., 16: 385, 1979

    Article  PubMed  CAS  Google Scholar 

  • Montolu, J., Botey, A., Torras, A. et al.: Renin-induced massive proteinuria in man. Clin. Nephrol. 11: 267, 1979

    Google Scholar 

  • Myer, R., Marshall, W., Jones, R. H. et al.: Characterization of diabetic proteinuria. La Ricerca Clin. Lab.10: 143, 1980

    Article  CAS  Google Scholar 

  • Ohen, D. E., Flamenbaum, W.: Micropuncture studies of proximal tubular albumin concentrations in normal and nephrotic rats. J. clin. Invest. 50: 1498, 1970

    Google Scholar 

  • Oken, D. E., Cotes, S. C., Mende, C. W.: Micropuncture study of tubular transport of albumin in rats with aminonucleoside nephrosis. Kidney int. 1: 3, 1972

    Article  PubMed  CAS  Google Scholar 

  • Oken, D. E.: Proteinuria and aminoaciduria. In: Pathophysiology of the kidneys. Ed.: N. A. Kurtzman, Springfield Thomas, 1976

    Google Scholar 

  • Pappenheimer, J. R.: Passage of molecules through capillary walls. Physiol. Rev. 33: 387, 1953

    PubMed  CAS  Google Scholar 

  • Pesce, A. J., First, M. R.: Proteinuria. M. Dekker, Inc., New York 1979

    Google Scholar 

  • Peterson, P. A., Ervin, P. E., Bergaard, I.: Differentiation of glomerular, tubular and normal proteinuria: determination of urinary excretion of Alpha2-macroglobulin, albumin and total protein. J. clin. Invest. 48: 1189, 1969

    Article  PubMed  CAS  Google Scholar 

  • Peterson, P. A., Evrin, P. E., Bergaard, I.: Determination of urinary excretion of Alpha2 -microglobulin, albumin and total protein. J. clin. Invest. 48: 1189, 1969

    Article  PubMed  CAS  Google Scholar 

  • Poortmans, J. R., van Kerchove, E.: La proteinurie d’effort. Clin. Chim. Acta 7: 229, 1962

    Article  PubMed  CAS  Google Scholar 

  • Poortmans, J. R.: Effect of exercise on the renal clearance of amylase and lysozyme in humans. Clin. Sci. 43: 115, 1972

    PubMed  CAS  Google Scholar 

  • Poortmans, J. R., Vancalck, B.: Renal glomerular and tubular impairment during strenous exercise in young women. Europ. J. clin. Invest. 8: 175, 1978

    Article  PubMed  CAS  Google Scholar 

  • Poreh, S., Berlyne, G. M.: Renal protein clearances and selectivity of proteinuria in renal amyloid complicating familial mediterranean fever. Nephron, 13: 221, 1974

    Article  PubMed  CAS  Google Scholar 

  • Bright, R.: Cases and observations, illustrativc of renal disease accompanied with the secretion of albuminous urine. Guy’s Hospital Reports, I: 338, 1836

    Google Scholar 

  • Bulger, R. E.: Kidney morphology. In: Diseases of the kidney. L. E. Earley, C. W. Gottschalk, (eds.) Boston, Little, Brown 1979

    Google Scholar 

  • Butler, E. A., Flynn, F. V.: The proteinuria of renal tubular disorders. Lancet II: 978, 1958

    Google Scholar 

  • Cameron, J. S., Blandford, G.: The simple assessment of selectivity in heavy proteinuria. Lancet II: 242, 1966

    Article  Google Scholar 

  • Cameron, J. S.: The history of proteinuria. In: Proteins in normal and pathological urine. Manuel, J., Revillard, J. P., Betuel, H. (Eds.). Baltimore, Univ. Park Press, 1970

    Google Scholar 

  • Carone, F. A., Bansk, D. B., Post, R. S.: Micropuncture study of albumin excretion in the normal rat. 66th Meeting of the Amer. Assoc. of Pathologists and Bacteriologists, San Francisco 1969 Amer. J. Pathol. 55: 19a, 1969

    Google Scholar 

  • Carone, F., Peterson, D. R., Oparil, S., Pullman, T. N.: Renal tubular transport and catabolism of proteins and peptides. Kidney int. 16: 271, 1979

    Article  PubMed  CAS  Google Scholar 

  • Carrie, B. J., Hilberman, M., Schroeder, J. S., Myers, B. D.: Albuminuria and the permselective properties of the glomerulus in cardiac failure. Kidney int. 17: 507, 1980

    Article  PubMed  CAS  Google Scholar 

  • Carrie, B. J., Salyer, W. R., Myers, B. D.: Minimal change nephropathy: An electrochemical disorder of the glomerular membrane. Am. J. Med. 70: 262, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Chinard, F. P.: Derivation of an expression for the rate of formation of glomerular fluid (GFR). Applicability of certain physical and physicochemical concepts. Am. J. Physiol. 171: 578, 1952

    PubMed  CAS  Google Scholar 

  • Clyne, D. H., Kant, K. S., Peace, A. J., Pollak, V. E.: Nephrotoxicity of low molecular weight serum proteins: Physicochemical interaction between myoglobin, hemoglobin, Bence-Jones proteins and Tamm-Horsfall mucoprotein. In: Current Problems in clin. Biochem. vol. 9. U. C. Dubach, W. Schmidt (Eds.), H. Huber. Bern 1979

    Google Scholar 

  • Doetsch, K., Gadsden, R. H.: Determination of urinary total protein by use of gel filtration and a modified biuret method. Clin. Chem. 21: 778, 1975

    PubMed  CAS  Google Scholar 

  • Engle, R. L., Wallis, L. A.: Multiple myeloma and the adult Fanconi syndrome. Am. J. Med. 22: 5, 1957.

    Article  PubMed  Google Scholar 

  • Evrin, P. E., Wibel, L.: The serum levels and urinary excretion of Beta2-microglobulin in apparently healthy subjects. Scand. J. clin. lab. Invest. 29: 69, 1972

    Article  PubMed  CAS  Google Scholar 

  • Fahre, J., Balant, L. Ducrey, J., Giromini, M.: Proteinuria in diabetes. Abstr. No. 579 of the VIth Int. Congress Nephrol., Florencia, Italy 1975

    Google Scholar 

  • Free, A., Free, H.: Urinalysis in clinical laboratory practice. West Palm Beach, CRC Press 1975

    Google Scholar 

  • Gyure, W. L.: Comparison of several methods for semiquantitative determination of urinary protein. Clin. Chem. 23: 816, 1977

    Google Scholar 

  • Hardwicke, J., Squire, J. R.: The relationship between plasma albumin concentration and protein: excretion in patients with proteinuria. Clin. Sci. 14: 509, 1955

    PubMed  CAS  Google Scholar 

  • Hardwicke, J., Soothil, J. F.: Glomerular damage in terms of „pore size“. In: Ciba Foundation. Symposium on Renal Biopsy G. E. W. Wolstenholme, M. P. Cameron, (eds.) Churchill, London 1961

    Google Scholar 

  • Hemmingsen, L., Skaarup, P.: The 24-hour excretion of plasma proteins in the urine of apparently healthy subjects. Scand. J. clin. lab. Invest. 35: 347, 1975

    Article  PubMed  CAS  Google Scholar 

  • Hulme, B., Hardwicke, J.: Human glomerular permeability to macromolecules in health and disease. Clin. Sci. 34: 515, 1968.

    Google Scholar 

  • Iwata, J., Nishikaze, O.: New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine. Clin. Chem. 25: 1317, 1979

    PubMed  CAS  Google Scholar 

  • Joachim, G. R., Cameron, J. S., Schwartz, M., Becker, E. L.: Selectivity of protein excretion in patients with the nephrotic syndrome. J. clin. Invest. 43: 2332, 1964

    Article  PubMed  CAS  Google Scholar 

  • Johansson, B. G. Agarose gel electrophoresis. Scand. J. clin. lab. Invest.29: Suppl. 124: 7–19, 1972

    Article  CAS  Google Scholar 

  • Renner, E., Heinecke, G., Lange, H.: Clinical value of the renal protein clearance determination. Contr. Nephrol.1: 134, S. Karger, Basel 1975

    CAS  Google Scholar 

  • Robinson, R. R., Glenn, W. G.: Fixed and reproducible orthostatic proteinuria. J. lab. clin. Med. 64: 717, 1964

    PubMed  CAS  Google Scholar 

  • Robinson, R. R.: Isolated proteinuria in asymptomatic patients. Kidney int. 18: 395, 1980

    Article  PubMed  CAS  Google Scholar 

  • Rosenmann, F., Boss, J. H.: Tissue antigens in normal and pathologic urine samples: A review. Kidney int. 16: 337, 1979

    Article  PubMed  CAS  Google Scholar 

  • Schnitze, H. E., Heremans, J. F.: Molecular biology of human proteins. Amsterdam, Elsevier, 1966

    Google Scholar 

  • Sehti, K., First, M. R., Pesce, A. J. et al.: Proteinuria following renal transplantation. Nephron 18: 49, 1977

    Article  Google Scholar 

  • de Seigneux, R., Schwarz, R., Balant, L., Fahre, J.: Aspects initiaux des alterations de la proteinurie ches les diabetiques. Schweiz. med. Wschr.110: 295, 1980

    PubMed  Google Scholar 

  • Smithline, N., Kassirer, J. P., Cohen, J. J.: Light-chain nephropathy: Renal tubular dysfunction associated with light-chain proteinuria. N. Engl. J. Med. 29: 71, 1976.

    Article  Google Scholar 

  • Solling, K., Mogensen, C. E., Vittinghus, E., Brock, A.: The renal handling of amylase in normal man. Nephron 23: 282, 1979

    Article  Google Scholar 

  • Snapper, I., Kahn, A.: Myelomatosis. Basel, S. Karger, 1971

    Google Scholar 

  • Stolte, H., Alt, J., Schurek, H. J.: Experimentelle und klinische Untersuchungen zur Differentialdiagnostik der Proteinurie. Klin. Wschr. 57: 1069, 1979

    Article  PubMed  CAS  Google Scholar 

  • Thompson, A. L., Durrett, R. R., Robinson, R. R.: Fixed and reproducible orthostatic proteinuria: VI. Results of a 10-year follow up evaluation. Ann. intern. Med. 73: 235, 1970.

    PubMed  CAS  Google Scholar 

  • Thysell, H.: A comparison between Albustix, Hema-Combistix, Labstix, the sulphosalicylic-acid test, Heller’s nitric acid test and a biuret method. Acta med. Scand. 185: 401, 1969

    Article  PubMed  CAS  Google Scholar 

  • Viberti, G. C., MacIntosh, D., Bilous, R. W. et al.: Proteinuria in diabetes mellitus: role of spontaneous and experimental variation of glycemia. Kidney int. 21: 714, 1982

    Article  PubMed  CAS  Google Scholar 

  • Vittinghus, E., Mogensen, C. K.: Graded exercise and protein excretion in diabetic man and the effect of insulin treatment. Kidney int. 21: 725, 1982

    Article  PubMed  CAS  Google Scholar 

  • Wallenius, G.: Renal clearance of dextran as measure of glomerular permeability. Acta Soc. Med. Upp.59: 1, 1954

    CAS  Google Scholar 

  • Wibell, L., Karlsson, A.: Urinary excretion of Alpha2 microglobulin after the induction of diuresis. Nephron 17: 343, 1976

    Article  PubMed  CAS  Google Scholar 

  • Wieslander, J., Byrgen, P., Heinegard, D.: Determination of the Tamm-Horsfall glycoprotein in human urine. Clin. Chim. Acta 78: 391, 1977

    Article  PubMed  CAS  Google Scholar 

  • Yatzidis, H.: New colorimetric method for quantitative determination of protein in urine. Clin. Chem. 23: 811, 1977

    PubMed  CAS  Google Scholar 

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Schück, O. (1984). Proteinuria. In: Examination of Kidney Function. Developments in Nephrology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5660-5_4

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  • DOI: https://doi.org/10.1007/978-94-009-5660-5_4

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