Abstract
The relation between foam formation on the surface of urine and kidney disease was known by Hippocrates (cf. Cameron 1970). An actual demonstration of the presence of protein in the urine, however, had to wait until the dawn of scientific methods. Frederick Dekkers in 1673 started to use a heat coagulation test to demonstrate protein in the urine (cf. Free and Free 1975). The first physician to show clearly that patients with demonstrable anatomical pathology of the kidneys excreted an albuminous protein into the urine was Richard Bright (1836). Twelve years later Watson (cf.Snapper and Kahn 1971) and Bence-Jones (1848) described a quite different protein from that described by Bright in the urine. In 1878, Leube described proteinuria in soldiers after severe exercise, and in the same year Moxon described a postural stimulus to proteinuria (cf. Pesce and First 1979).
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References
Anderson, N. G., Anderson, N. L., Tollaksen, S. L.: Proteins in human urine: I. Concentration and analysis by two-dimensional electrophoresis. Clin. Chem. 25: 1199, 1979
Alt, J. M., Jänig, H., Schurek, H. J., Stolte, H.: Study of renal protein excretion in chronic pyelonephritis. Contr. Nephrol. 16: 37–43, 1979
Antoine, B., Neven, Th.: Pathological urinary excretion of tissue macromolecules (histuria). J. lab. clin. Med. 71: 101, 1968
Balant, L., Fahre, J.: Clinical relevance of different electrophoretic methods for the analysis of urinary proteins. In: Current Problems in Clinical Biochemistry, vol. 9. U. C. Dubach, W, Schmidt (eds.), H. Bern, Huber, 1979
Bence Jones, H.: On a new substance occurring in the urine of a patient with mollities ossium. Phil. Transac. Royal Soc. London, I., 1848
Bennett, C. M., Glassock, R. J., Chang, R. L. S., Deen, W. M., Robertson, C. R., Brenner, B. M.: Permselectivity of the glomerular capillary wall: Studies of experimental glomerulonephritis in the rat using dextran sulfate. J. clin. Invest. 57: 1287, 1976.
Bergaard, I.: Studies on proteins, glycoproteins and mucopolysaccharides in normal human urine. Acta Soc. Med. Upps. 66: 230, 1961
Bergaard, I.: Plasma protein in normal human urine. In: Proteins in normal and pathological urine. Y. Manuel, J. P. Rewillard (eds.) Basel Karger, 1970
Bienenstock, G. M., Tomasi, T. B. Jr.: Sectory IgA in normal urine. J. clin. Invest. 47: 1162, 1968
Bienenstock, J., Poortmans, J.: Renal clearance of 15 plasma proteins in renal disease. J. lab. clin. Med. 75: 297, 1970
Blainey, J. D., Brewer, D. B., Hardwicke, J.: Proteinuria and the nephrotic syndrome. In: Renal disease (Eds. D. Black and N. F. Jones). 4 ed. Oxford, Blackwell, 1979, pp. 383–399.
Blainey, J. D., Brewer, D. B., Hardwicke, J., Soothill, J. F.: The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Quart. J. Med. 29: 23, 1960
Boesken, W. H.: Disclelectrophoretic molecular weight analysis of urinary proteins. Contr. Nephrol. 1: 143, 1975
Boesken, W. M.: Diagnostic significance of SDC-PAA electrophoresis of urinary proteins. In: Current Problems in Clin. Bioch., vol. 9. U. C. Dubach, W. Schmidt (eds.). Bern, H. Huber, 1979
Bohrer, M. P., Baylis, C., Robertson, C. R., Brenner, B. M.: Mechanism of the puromycin-induced defects in the transglomerular passage of water and macromolecules. J. clin. Invest. 69: 152, 1977
Boileau, M., Fuchs, E., Barry, J. M., Hodges, C. V.: Stress haematuria: Athletic pseudonephritis in marathoners. Urology, 15: 471, 1980
Karlsson, F. A., Wibell, L., Ervin, P. E.: Beta-2-microglobulin in clinical medicine. Scand. J. clin. lab. Invest 40 (suppl. 154): 27, 1980
Kassirer, J. P., Gennari: Laboratory evaluation of renal function. In Strauss and Welt’s Diseases of the kidney. Third ed. (Eds. L. E. Early and. C. W. Gottschalk). pp 41–91. Boston, Little, Brown, 1979.
King, J. S., Jr., Boyce, W. H., Little, J. M., Artom, C.: Total nondialyzable solids (TNDS) in human urine. I. The amount and composition of TNDS from normal subjects. J. clin. Invest. 37: 315, 1958
Leskovar, P., Kratzer, M.: Electrophoretische Erfassung der einzelnen Harnproteinfraktionen. Med. Welt, 30: 47, 1777, 1979
Maack, T. M., Sherman, R. L.: Proteinuria. Am. J. Med. 56: 71, 1974
Maack, T., Johnson, V. Kau, S. T. et al.: Renal filtration, transport and metabolism of low molecular-weight proteins. A review. Kidney. int. 16: 251, 1979
MacLean, P. R., Robson, J. S.: A simple method for determining selectivity of proteinuria. Lancet I: 539, 1967
Maldonado, J. E., Velosa, J. A., Kyle, R. A., Wagoner, R. D., Holley, K. E., Salasa, R. M.: Fanconi syndrome in adults: A manifestation of a latent form of myeloma. Am. J. Med. 58: 354, 1975.
Mannuel, Y., Revillard, J. P.: Study of urinary proteins by zone electrophoresis. In: Proteins in normal and pathological urine. Mannuel Y., Revillard, J. P., Betiel, H. (eds.) S. Karger, Basel 1970, pp. 153–171
Mannuel, Y., Colle, A., Leclercq, M., Tonnelle, C.: Low molecular weight proteinuria. Contr. Nephrol. 1: 156, 1975
Misra, R. P., Berman, L. B.: The molecular basis of proteinuria. JAMA 242: 757, 1979
Mogensen, C. E., Vittinghus, E., Soiling, K.: Abnormal albumin excretion after two provocative renal tests in diabetics: physical exercise and lysine injection. Kidney int., 16: 385, 1979
Montolu, J., Botey, A., Torras, A. et al.: Renin-induced massive proteinuria in man. Clin. Nephrol. 11: 267, 1979
Myer, R., Marshall, W., Jones, R. H. et al.: Characterization of diabetic proteinuria. La Ricerca Clin. Lab.10: 143, 1980
Ohen, D. E., Flamenbaum, W.: Micropuncture studies of proximal tubular albumin concentrations in normal and nephrotic rats. J. clin. Invest. 50: 1498, 1970
Oken, D. E., Cotes, S. C., Mende, C. W.: Micropuncture study of tubular transport of albumin in rats with aminonucleoside nephrosis. Kidney int. 1: 3, 1972
Oken, D. E.: Proteinuria and aminoaciduria. In: Pathophysiology of the kidneys. Ed.: N. A. Kurtzman, Springfield Thomas, 1976
Pappenheimer, J. R.: Passage of molecules through capillary walls. Physiol. Rev. 33: 387, 1953
Pesce, A. J., First, M. R.: Proteinuria. M. Dekker, Inc., New York 1979
Peterson, P. A., Ervin, P. E., Bergaard, I.: Differentiation of glomerular, tubular and normal proteinuria: determination of urinary excretion of Alpha2-macroglobulin, albumin and total protein. J. clin. Invest. 48: 1189, 1969
Peterson, P. A., Evrin, P. E., Bergaard, I.: Determination of urinary excretion of Alpha2 -microglobulin, albumin and total protein. J. clin. Invest. 48: 1189, 1969
Poortmans, J. R., van Kerchove, E.: La proteinurie d’effort. Clin. Chim. Acta 7: 229, 1962
Poortmans, J. R.: Effect of exercise on the renal clearance of amylase and lysozyme in humans. Clin. Sci. 43: 115, 1972
Poortmans, J. R., Vancalck, B.: Renal glomerular and tubular impairment during strenous exercise in young women. Europ. J. clin. Invest. 8: 175, 1978
Poreh, S., Berlyne, G. M.: Renal protein clearances and selectivity of proteinuria in renal amyloid complicating familial mediterranean fever. Nephron, 13: 221, 1974
Bright, R.: Cases and observations, illustrativc of renal disease accompanied with the secretion of albuminous urine. Guy’s Hospital Reports, I: 338, 1836
Bulger, R. E.: Kidney morphology. In: Diseases of the kidney. L. E. Earley, C. W. Gottschalk, (eds.) Boston, Little, Brown 1979
Butler, E. A., Flynn, F. V.: The proteinuria of renal tubular disorders. Lancet II: 978, 1958
Cameron, J. S., Blandford, G.: The simple assessment of selectivity in heavy proteinuria. Lancet II: 242, 1966
Cameron, J. S.: The history of proteinuria. In: Proteins in normal and pathological urine. Manuel, J., Revillard, J. P., Betuel, H. (Eds.). Baltimore, Univ. Park Press, 1970
Carone, F. A., Bansk, D. B., Post, R. S.: Micropuncture study of albumin excretion in the normal rat. 66th Meeting of the Amer. Assoc. of Pathologists and Bacteriologists, San Francisco 1969 Amer. J. Pathol. 55: 19a, 1969
Carone, F., Peterson, D. R., Oparil, S., Pullman, T. N.: Renal tubular transport and catabolism of proteins and peptides. Kidney int. 16: 271, 1979
Carrie, B. J., Hilberman, M., Schroeder, J. S., Myers, B. D.: Albuminuria and the permselective properties of the glomerulus in cardiac failure. Kidney int. 17: 507, 1980
Carrie, B. J., Salyer, W. R., Myers, B. D.: Minimal change nephropathy: An electrochemical disorder of the glomerular membrane. Am. J. Med. 70: 262, 1981.
Chinard, F. P.: Derivation of an expression for the rate of formation of glomerular fluid (GFR). Applicability of certain physical and physicochemical concepts. Am. J. Physiol. 171: 578, 1952
Clyne, D. H., Kant, K. S., Peace, A. J., Pollak, V. E.: Nephrotoxicity of low molecular weight serum proteins: Physicochemical interaction between myoglobin, hemoglobin, Bence-Jones proteins and Tamm-Horsfall mucoprotein. In: Current Problems in clin. Biochem. vol. 9. U. C. Dubach, W. Schmidt (Eds.), H. Huber. Bern 1979
Doetsch, K., Gadsden, R. H.: Determination of urinary total protein by use of gel filtration and a modified biuret method. Clin. Chem. 21: 778, 1975
Engle, R. L., Wallis, L. A.: Multiple myeloma and the adult Fanconi syndrome. Am. J. Med. 22: 5, 1957.
Evrin, P. E., Wibel, L.: The serum levels and urinary excretion of Beta2-microglobulin in apparently healthy subjects. Scand. J. clin. lab. Invest. 29: 69, 1972
Fahre, J., Balant, L. Ducrey, J., Giromini, M.: Proteinuria in diabetes. Abstr. No. 579 of the VIth Int. Congress Nephrol., Florencia, Italy 1975
Free, A., Free, H.: Urinalysis in clinical laboratory practice. West Palm Beach, CRC Press 1975
Gyure, W. L.: Comparison of several methods for semiquantitative determination of urinary protein. Clin. Chem. 23: 816, 1977
Hardwicke, J., Squire, J. R.: The relationship between plasma albumin concentration and protein: excretion in patients with proteinuria. Clin. Sci. 14: 509, 1955
Hardwicke, J., Soothil, J. F.: Glomerular damage in terms of „pore size“. In: Ciba Foundation. Symposium on Renal Biopsy G. E. W. Wolstenholme, M. P. Cameron, (eds.) Churchill, London 1961
Hemmingsen, L., Skaarup, P.: The 24-hour excretion of plasma proteins in the urine of apparently healthy subjects. Scand. J. clin. lab. Invest. 35: 347, 1975
Hulme, B., Hardwicke, J.: Human glomerular permeability to macromolecules in health and disease. Clin. Sci. 34: 515, 1968.
Iwata, J., Nishikaze, O.: New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine. Clin. Chem. 25: 1317, 1979
Joachim, G. R., Cameron, J. S., Schwartz, M., Becker, E. L.: Selectivity of protein excretion in patients with the nephrotic syndrome. J. clin. Invest. 43: 2332, 1964
Johansson, B. G. Agarose gel electrophoresis. Scand. J. clin. lab. Invest.29: Suppl. 124: 7–19, 1972
Renner, E., Heinecke, G., Lange, H.: Clinical value of the renal protein clearance determination. Contr. Nephrol.1: 134, S. Karger, Basel 1975
Robinson, R. R., Glenn, W. G.: Fixed and reproducible orthostatic proteinuria. J. lab. clin. Med. 64: 717, 1964
Robinson, R. R.: Isolated proteinuria in asymptomatic patients. Kidney int. 18: 395, 1980
Rosenmann, F., Boss, J. H.: Tissue antigens in normal and pathologic urine samples: A review. Kidney int. 16: 337, 1979
Schnitze, H. E., Heremans, J. F.: Molecular biology of human proteins. Amsterdam, Elsevier, 1966
Sehti, K., First, M. R., Pesce, A. J. et al.: Proteinuria following renal transplantation. Nephron 18: 49, 1977
de Seigneux, R., Schwarz, R., Balant, L., Fahre, J.: Aspects initiaux des alterations de la proteinurie ches les diabetiques. Schweiz. med. Wschr.110: 295, 1980
Smithline, N., Kassirer, J. P., Cohen, J. J.: Light-chain nephropathy: Renal tubular dysfunction associated with light-chain proteinuria. N. Engl. J. Med. 29: 71, 1976.
Solling, K., Mogensen, C. E., Vittinghus, E., Brock, A.: The renal handling of amylase in normal man. Nephron 23: 282, 1979
Snapper, I., Kahn, A.: Myelomatosis. Basel, S. Karger, 1971
Stolte, H., Alt, J., Schurek, H. J.: Experimentelle und klinische Untersuchungen zur Differentialdiagnostik der Proteinurie. Klin. Wschr. 57: 1069, 1979
Thompson, A. L., Durrett, R. R., Robinson, R. R.: Fixed and reproducible orthostatic proteinuria: VI. Results of a 10-year follow up evaluation. Ann. intern. Med. 73: 235, 1970.
Thysell, H.: A comparison between Albustix, Hema-Combistix, Labstix, the sulphosalicylic-acid test, Heller’s nitric acid test and a biuret method. Acta med. Scand. 185: 401, 1969
Viberti, G. C., MacIntosh, D., Bilous, R. W. et al.: Proteinuria in diabetes mellitus: role of spontaneous and experimental variation of glycemia. Kidney int. 21: 714, 1982
Vittinghus, E., Mogensen, C. K.: Graded exercise and protein excretion in diabetic man and the effect of insulin treatment. Kidney int. 21: 725, 1982
Wallenius, G.: Renal clearance of dextran as measure of glomerular permeability. Acta Soc. Med. Upp.59: 1, 1954
Wibell, L., Karlsson, A.: Urinary excretion of Alpha2 microglobulin after the induction of diuresis. Nephron 17: 343, 1976
Wieslander, J., Byrgen, P., Heinegard, D.: Determination of the Tamm-Horsfall glycoprotein in human urine. Clin. Chim. Acta 78: 391, 1977
Yatzidis, H.: New colorimetric method for quantitative determination of protein in urine. Clin. Chem. 23: 811, 1977
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Schück, O. (1984). Proteinuria. In: Examination of Kidney Function. Developments in Nephrology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5660-5_4
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