Skip to main content
SpringerLink
Log in

Effects of prostaglandins on the human non-pregnant uterus and ovary

  • Chapter
Book cover Prostaglandins and Fertility Regulation

Part of the book series: Advances in Reproductive Health Care ((ARHE,volume 4))

  • 44 Accesses

Abstract

There are at least four fundamental areas in human reproduction where Prostaglandins (PGs) are involved. These are the possible physiological role in the regulation of reproductive events, their implications in pathological situations and functional disorders, their involvement as mediators to pharmacological agents, and their application to induce therapeutic effects. Many of the suggested diverse actions and versatile roles remain conjectural due to analytical problems or difficulties in interpretation of data extracted from in vitro and animal experiments which may not be applicable to the human situation. Moreover, biological effects in response to pharmacological doses of PGs may not reflect a physiological role.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abdalla, M. I., Ibrahim, I. I. and Osman, M. I. (1979). Effect of Prostaglandin E2 derivative (Sulprostone) on the pituitary ovarian function in non-pregnant females. In Friebel, K., Schneider, A. and Wurfel, H. (eds.) International Sulprostone Symposium, pp. 113–118. Vienna, November, 1978. (Schering AG)

    Google Scholar 

  • Akerlund, M. (1979). Pathophysiology of dysmenorrhea. Acta. Obstet. Gynecol. (Suppl.), 87, 27–35

    Article  CAS  Google Scholar 

  • Akerlund, M., Andersson, K. E. and Ingmarsson, I. (1976). Effects of terbutaline on myometrial activity, endometrial blood flow and lower abdominal pain in women with primary dysmenorrhea. Br. J. Obstet. Gynaecol., 83, 673–678

    Article  PubMed  CAS  Google Scholar 

  • Aksel, S., Shromberg, D. W. and Hammond, C. B. (1977). Prostaglandin F2α production by the human ovary. Obstet. Gynecol., 50, 347–350.

    PubMed  CAS  Google Scholar 

  • Beers, W. H., Strickland, S. and Reich, E. (1975). Ovarian Plasminogen activator: Relationships to ovulation and hormonal regulation. Cell, 6, 387–397

    Article  PubMed  CAS  Google Scholar 

  • Bendz, A. (1977). The anatomical basis for a possible counter current exchange mechanism in the human adnex. Prostaglandins, 13, 355–362

    Article  PubMed  CAS  Google Scholar 

  • Bolognese, R. J. and Corson, S. L. (1973). The effect of vaginally administered Prostaglandin F2α on corpus luteum function. Am. J. Obstet. Gynecol., 117, 240–245

    PubMed  CAS  Google Scholar 

  • Borda, E. S., Agostini, M. C., Sterin-Speziale, N., Gimeno, M. F. and Gimeno, A. L. (1979). Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2). Prostaglandins, 18, 829–835

    Article  PubMed  CAS  Google Scholar 

  • Bygdeman, M., Fredricsson, B., Svanborg, K. and Samuelsson, B. (1970). The relation between fertility and Prostaglandin content of seminal fluid in man. Fertil. Steril., 21, 622–629

    PubMed  CAS  Google Scholar 

  • Bygdeman, M., Bremme, K., Gillespie, A. and Lundstrom, V. (1979). Effects of Prostaglandins on the uterus. Prostaglandins and uterine contractility. Acta Obstet. Gynecol. Scand., Suppl. 87, 33–38

    Article  CAS  Google Scholar 

  • Carlson, J. C., Wong, A. P. and Perrin, D. G. (1977). The effects of Prostaglandin and mating on release of LH in the female rabbit. J. Reprod. Fertil., 51, 87–92

    Article  PubMed  CAS  Google Scholar 

  • Challis, J. R. G., Calder, A. A., Dilley, S., Forster, C. S., Hillier, K., Hunter, D. J. S. Mackenzie, I. Z. and Thorburn, G. D. (1976). Production of Prostaglandins E and F2α by corpora lutea, corpora albicantes and stroma from the human ovary. J. Endocrinol., 68, 401–408

    Article  PubMed  CAS  Google Scholar 

  • Channing, C. P. (1972). Stimulatory effects of Prostaglandins upon luteinization of rhesus monkey granulosa cell cultures. Prostaglandins, 2, 331–349

    Article  PubMed  CAS  Google Scholar 

  • Chaudhuri, G. and Elder, M. G. (1976). Lack of evidence for inhibition of ovulation by aspirin in women. Prostaglandins, 11, 727–735

    Article  PubMed  CAS  Google Scholar 

  • Clithero, H. J. and Pickles, V. R. (1961). The separation of the smooth muscle stimulants in menstrual fluid. J. Physiol. (Lond.), 156, 225–237

    Google Scholar 

  • Coudert, S. P. and Faiman, C. (1973). Effect of PGF2α on anterior pituitary function in man. Prostaglandins, 3, 89–95

    Article  PubMed  CAS  Google Scholar 

  • Coudert, S. P., Winter, J. S. D. and Faiman, C. (1974). Transient decline in serum progesterone levels during Prostaglandin F2α infusion in the mid-luteal phase of the normal menstrual cycle. Am. J. Obstet. Gynecol., 119, 755–761

    PubMed  CAS  Google Scholar 

  • Coutinho, E. M. and Darzé, E. (1976). Spontaneous contractility and the response of the human uterine cervix to Prostaglandin F2α and E2 during the menstrual cycle. Am. J. Obstet. Gynecol., 126, 224–225

    PubMed  CAS  Google Scholar 

  • Coutinho, E. M. and Maia, H. (1971). The contractile response of the human uterus, Fallopian tubes, and ovary to Prostaglandins in vivo. Fertil. Steril:, 22, 539–543

    PubMed  CAS  Google Scholar 

  • Coutinho, E. M. and Maia, H. S. (1972). Effects of gonadotrophin on motility of human ovary. Nature New Biol., 235, 94–96

    PubMed  CAS  Google Scholar 

  • Coutinho, E. M., Maia, H. S. and Schally, A. V. (1974). Changes in intra-ovarian pressure in women following the administration of luteinizing-hormone releasing hormone (LH-RH). Int. J. Fertil., 19, 89–92

    Google Scholar 

  • Coyotupa, J., Buster, J., Parlow, A. and Dignam, W. (1973). Normal cyclical patterns of serum gonadotrophins and ovarian steroids despite congenital absence of the uterus. J. Clin. Endocrinol. Metab., 36, 395–399

    Article  PubMed  CAS  Google Scholar 

  • Craig, G. M. (1975). The effect of intravenous PGF2α on serum luteinizing hormone, follicle stimulating hormone and plasma cortisol in normal men. J. Clin. Endocrinol. Metab., 41, 180–182

    Article  PubMed  CAS  Google Scholar 

  • Csapo, A. I. and Pinto-Dantas, C. R. (1966). The cyclic activity of the non-pregnant uterus, A new method for recording intra-uterine response. Fertil. Steril., 17, 34–38

    PubMed  CAS  Google Scholar 

  • Darling, M. R. N., Jogee, M. and Elder, M. G. (1982). Prostaglandin F2α levels in the human ovarian follicle. Prostaglandins, 23, 551–556

    Article  PubMed  CAS  Google Scholar 

  • Dennefors, B., Tjugum, J., Norstrom, A., Janson, P. O., Nilsson, L., Hamberger, L. and Wilhelmsson, L. (1982). Collagen synthesis inhibition by PGE2 within the human follicular wall-one possible mechanism underlying ovulation. Prostaglandins, 24, 295–302

    Article  PubMed  CAS  Google Scholar 

  • Doyle, L. L., Barclay, D. L., Duncan, G. W. and Kirton, K. T. (1971). Human luteal function following hysterectomy as assessed by plasma progestin. Am. J. Obstet. Gynecol., 110, 92–97

    PubMed  CAS  Google Scholar 

  • Edwards, R. G. (1973). Studies in human conception. Am. J. Obstet. Gynecol., 117, 587–601

    PubMed  CAS  Google Scholar 

  • Einer-Jensen, N. (1973). Decreased endometrial blood flow and plasma progesterone level after instillation of 10 μg PGF2α into the lumen of the uteri of rhesus monkeys. Prostaglandins, 4, 517–533

    Article  CAS  Google Scholar 

  • El-Dakhakhny, M. M. (1980). Response of the non-pregnant human uterus to Prostaglandin E2 and its derivatives under different hormonal conditions. Ph.D. thesis. The University of Alexandria, Egypt

    Google Scholar 

  • Elder, M. G. and Coutinho, E. M. (1977). Human ovarian motility induced by PGE2α. Quoted by Darling et al. (1982), Prostaglandins, 23, 551

    Google Scholar 

  • Elias, J. A., Newton, J. R. and Collins, W. P. (1975). Changes in ovarian and pituitary function in non-pregnant women during the infusion of PGF2α. Acta Endocrinol, 80, 676–685

    PubMed  CAS  Google Scholar 

  • El-Tarahony, A. L. H. (1982). Effect of LHRH and HCG on the uterine response to local PGE2 in non-pregnant women. M.S. thesis, The University of Alexandria, Egypt

    Google Scholar 

  • Espey, L. L. (1967). Ultrastructure of the rabbit Graafian follicle during the ovulatory process. Endocrinology, 81, 267–276

    Article  PubMed  CAS  Google Scholar 

  • Filler, W. and Warner, J. (1970). Dysmenorrhoea and its therapy. A uterine contractility study. Am. J. Obstet. Gynecol., 106, 104–109

    PubMed  Google Scholar 

  • Green, K., Samuelsson, B., Carlson, J. and McCracken, J. (1972). Prostaglandin F2α identified as a luteolytic hormone in the sheep. Fourth International Congress Endocrinol. Pages 189–203. Excerpta Medica, Amsterdam, International Congress Series 256

    Google Scholar 

  • Greenway, F. L. and Swerdloff, R. S. (1978). Effect of aspirin on ovulation. Fertil. Steril., 30, 364–373

    PubMed  CAS  Google Scholar 

  • Halbert, D. R., Demers, L. M., Fontana, J. and Jones, D. E. D. (1975). Prostaglandin levels in endometrial jet wash specimens in patients with dysmenorrhoea before and after indomethacin therapy. Prostaglandins, 10, 1047–1056

    Article  PubMed  Google Scholar 

  • Hamberger, L., Nilsson, L., Dennefors, B., Khan, I. and Sjorgen, A. (1979). Cyclic AMP formation of isolated human corpora lutea in response to HCG-Interference by PGF2α. Prostaglandins, 17, 615–621

    Article  PubMed  CAS  Google Scholar 

  • Hamberger, L., Dennefors, B., Hamberger, B., Janson, P. O., Nilsson, L., Sjorgen, A. and Wiqvist, N. (1980). Is vascular innervation a prerequisite for PG-induced luteolysis in the human corpus luteum? In Samuelsson, B., Ramwell, P. and Pasletti, R. (eds.). Advances in Prostaglandin and Thromboxane Research, vol. 8, pp. 1365–1368. ( New York: Raven Press )

    Google Scholar 

  • Henderson, K. M. and McNatty, K. P. (1975). A biochemical hypothesis to explain mechanism of luteal regression. Prostaglandins, 9, 779–797

    Article  PubMed  CAS  Google Scholar 

  • Henzl, M. R., Ortega, E., Gallegos-Cortes, V., Tomlinson, R. V. and Segre, E. J. (1973). Prostaglandin E2 and the luteal phase of the menstrual cycle: Effects on blood progesterone, estradiol, cortisol and growth hormone levels. J. Clin. Encrinol. Metab., 36, 784–787

    Article  CAS  Google Scholar 

  • Hillier, K., Dutton, A., Corker, C. S., Singer, A and Embery, M. P. (1972). Plasma steroid and luteinizing hormone levels during PGF2α administration in luteal phase of menstrual cycle. Br. Med. J., 11 November, 333–336

    Google Scholar 

  • Itoh, K. and Kunimoto, K. (1982). PG levels in venous plasma at menstrual cycle related to deficient corpus luteum - as a cause of infertility. Int. Conference on PGs (Abstracts), Florence, May 1982, p. 386

    Google Scholar 

  • Jewelewicz, R., Cantor, B., Dyrenfurth, I., Warren, M. P. and Vande-Wiele, R. L. (1972). Intravenous infusion of PGF2α in the mid-luteal phase in the normal human menstrual cycle. Prostaglandins, 1, 443–451

    Article  PubMed  CAS  Google Scholar 

  • Jones, G. S. and Wentz, A. C. (1972). The effect of Prostaglandin F2α infusion on corpus luteum function. Am. J. Obstet. Gynecol., 114, 393–404

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M., Hillier, K., Sommers, K. and Trussell, R. R. (1971). The effects of Prostaglandins E2 and F2α administered by different routes on uterine activity and the cardiovascular system in pregnant and non-pregnant women. J. Obstet. Gynecol. Br. Commonw., 78, 172–179

    Article  CAS  Google Scholar 

  • Kinoshita, K., Eneroth, P. and Bygdeman, M. (1979). Treatment with a single vaginal suppository containing 15-methyl PGF2α methyl ester at expected time of menstruation. Prostaglandins, 17, 469–481

    Article  PubMed  CAS  Google Scholar 

  • Kirton, K. T. (1975). Prostaglandins and reproduction in subhuman primates. In Karim, S. M. M. (ed.). Prostaglandins and Reproduction, pp. 229–240. ( Lancaster: MTP Press )

    Google Scholar 

  • Korda, A. R., Shutt, D. A., Smith, I. D., Shearman, R. P. and Lyneham, R. C. (1975). Assessment of possible luteolytic effect of intra-ovarian injection of Prostaglandin F2α in the human. Prostaglandins, 9, 443–449

    Article  PubMed  CAS  Google Scholar 

  • Leader, A., Bygdeman, M., Eneroth, P., Martin, J. N. Jr. and Wiqvist, N. (1976). The effect of infusion with two analogues of Prostaglandins F2α on corpus luteum function. In Samuelsson, B. and Paoletti, R. (eds.). Advances in Prostaglandins and Thromboxane Research. Vol. 2, pp. 679–684 (New York: Raven Press)

    Google Scholar 

  • Lehmann, F., Peters, F., Breckwoldt, M. and Bettendorf, G. (1972). Plasma progesterone levels during infusion of PGF2α in the human. Prostaglandins, 1, 269–277

    Article  PubMed  CAS  Google Scholar 

  • Lemaire, W. J. and Shapiro, W. G. (1972). Prostaglandin F2α. Its effect on the corpus luteum of the menstrual cycle. Prostaglandins, 1, 259–267

    Article  PubMed  CAS  Google Scholar 

  • Liedtke, M. P. and Seifert, B. (1978). Biosynthesis of Prostaglandins in human ovarian tissues. Prostaglandins, 16, 825–833

    Article  CAS  Google Scholar 

  • Lundstrom, V. (1977). The myometrial response to intra-uterine administration of PGF2α and PGE2 in dysmenorrheic women. Acta Obstet. Gynecol. Scand., 56, 167–172

    Article  PubMed  CAS  Google Scholar 

  • Lundstrom, V. and Green, K. (1978). Endogenous levels of Prostaglandin F2α and its main metabolites in plasma and endometrium of normal and dysmenorrhoic women. Am. J. Obstet. Gynecol., 130, 640–646

    PubMed  CAS  Google Scholar 

  • Lundstrom, V., Green, K. and Wiqvist, N. (1976). Prostaglandins, indomethacin and dysmenor-rhea. Prostaglandins, 11, 893–904

    Article  PubMed  CAS  Google Scholar 

  • Lundstrom, V., Green, K. and Svanborg, K. (1979). Endogenous Prostaglandins in dysmenor-rhoea and the effect of Prostaglandin synthetase inhibitor on uterine contractility. Acta Obstet. Gynecol Scand., Suppl. 87, 51–56

    Article  CAS  Google Scholar 

  • Lyneham, R. C., Korda, A. R., Shutt, D. A., Smith, I. D. and Shearman, R. P. (1975). The effect of intrauterine Prostaglandin F2α on corpus luteum function in the human. Prostaglandins, 9, 431–442

    Article  PubMed  CAS  Google Scholar 

  • Maathuis, J. B. and Kelly, R. W. (1978). Prostaglandin F2α and E2 in the endometrium throughout the menstrual cycle, after the administration of clomiphene or an estrogen-progestogen pill and in early pregnancy. J. Endocrinol, 77, 361–371

    Article  PubMed  CAS  Google Scholar 

  • Maia, H., Barbosa, I. and Coutinho, E. M. (1978). Inhibition of ovulation in marmoset monkeys by indomethacin. Fertil. Steril., 29, 565–570

    PubMed  CAS  Google Scholar 

  • Mann, E. C., Thomas, C. L. and Carmichael, D. E. (1962). Myometrial and isthmic mechanisms in primary dysmenorrhea. Obstet. Gynecol., 13, 408–414

    Google Scholar 

  • Marsh, J. M. and Lemaire, W. J. (1974). Cyclic AMP accumulation and steroidogenesis in human corpus luteum. Effect on gonadotrophins and Prostaglandins. J. Clin. Endocrinol. Metab., 38, 99–106

    Article  PubMed  CAS  Google Scholar 

  • Martin, J. N. Jr., Bygdeman, M. and Eneroth, P. (1978). The influence of locally administered Prostaglandin E2 and F2α on uterine motility in the intact non-pregnant human uterus. Acta Obstet. Gynecol. Scand., 57, 141–147

    Article  PubMed  CAS  Google Scholar 

  • McCann, S. M., Ojeda, S. R., Harms, P. G., Wheaton, J. E. Sundberg, D. J. T. and Fawcett, C. P. (1976). In Naftolin, F., Ryan, K. J. and Davies, J., (eds). Subcellular Mechanisms in Reproductive Neuroendocrinology. pp. 407–422. ( Amsterdam: Elsevier )

    Google Scholar 

  • McCracken, J. (1971). Prostaglandins and corpus luteum regression. Ann. N. Y. Acad. Sci., 180, 456–472

    Article  PubMed  CAS  Google Scholar 

  • Morales, T. I., Woessner, J. F., Howell, D. S., Marsh, J. M. and LeMaire, W. J. (1978). A microassay for the direct demonstration of collagenolytic activity in graafian follicles of the rat. Biochim. Biophys. Acta, 524, 428–434

    PubMed  CAS  Google Scholar 

  • Norstrom, A., Wilhelmsson, L. and Hamberger, L. (1981). The regulatory influence of Prostaglandins on protein synthesis on the human non-pregnant cervix. Prostaglandins, 22, 117–124

    Article  PubMed  CAS  Google Scholar 

  • Ojeda, S. R., Wheaton, J. E. and McCann, S. M. (1975). Prostaglandin E2 induced release of luteinizing hormone releasing factor (LRF). Neuroendocrinology, 17, 283–287

    Article  PubMed  CAS  Google Scholar 

  • Okamura, H., Aso., T., Yoshida, Y. and Nishimure, T. (1974). Effect of Prostaglandin F2α on human corpora lutea. Obstet. Gynecol NY, 44, 127–134

    CAS  Google Scholar 

  • Okamura, H., Virutamasen, P., Wright, K. H. and Wallach, E. E. (1972). Ovarian smooth muscle in the human being, rabbit and cat. Histochemical and electron microscopic study. Am. J. Obstet. Gynecol., 112, 183–191

    PubMed  CAS  Google Scholar 

  • Patrona, C. and Serra, G. B. (1974). Do pituitary Prostaglandins play an essential role in the action of LHRH in man. Prostaglandins, 6, 345–346

    Article  Google Scholar 

  • Patwardhan, V. V. and Lanthier, A. (1974). Effect of Prostaglandins on the in vitro steroid-genesis in human ovarian tissues. Prostaglandins, 6, 385–388

    Article  PubMed  CAS  Google Scholar 

  • Patwardhan, V. V. and Lanthier, A. (1980). Concentrations of Prostaglandins PGE and PGF, estrone, estradiol and progesterone in human corpora lutea. Prostaglandins, 20, 963–969

    Article  PubMed  CAS  Google Scholar 

  • Patwardhan, V. V. and Lanthier, A. (1981). Prostaglandins PGE and PGF in human ovarian follicles: Endogenous contents and in vitro formation by theca and granulosa cells. Acta Endocrinol. (Copenh)., 97, 543–550

    CAS  Google Scholar 

  • Pickles, V. R. (1959). Myometrial responses to the menstrual plain muscle stimulant. J. Endocrinol., 19, 150–157

    Article  PubMed  CAS  Google Scholar 

  • Pickles, V. R., Hall, W. J., Best, F. A. and Smith, G. N. (1965). Prostaglandins in endometrium and menstrual fluid from normal and dysmenorrhoeic subjects. J. Obstet. Gynaecol. Br. Commonw., 72, 185–192

    Article  PubMed  CAS  Google Scholar 

  • Plunkett, E. R., Moon, Y. S., Zamecnik, J. and Armstrong, D. T. (1975). Preliminary evidence of a role for Prostaglandin F in human follicular function. Am. J. Obstet. Gynecol., 123, 391–397

    PubMed  CAS  Google Scholar 

  • Powell, W. S., Hammarstrom, S. and Samuelsson, B. (1974). Prostaglandin F2α receptor in human corpora lutea. Lancet, 1, 1120

    Article  PubMed  CAS  Google Scholar 

  • Poyser, N. L. (1981). Prostaglandins in reproduction. In Bakhle, Y. S. (ed.), Research Studies Press. p. 108 ( Chichester: John Wiley )

    Google Scholar 

  • Pulkkinen, M. O. (1979). Suppression of uterine activity by Prostaglandin synthetase inhibitors. Acta Obstet. Gynecol. Scand., 87, 39–43

    Article  CAS  Google Scholar 

  • Pulkkinen, M. O., Henzl, M. R. and Csapo, M. I. (1978). The effect of Naproxen-sodium on the Prostaglandin concentrations of the menstrual blood and uterine ‘jet-washings’ in dysmenor-rheic women. Prostaglandins, 15, 543–550

    Article  PubMed  CAS  Google Scholar 

  • Rahman, H. A., El-Sokkary, H. A., El-Abd, M. M., Shaala, S. A., Gaweesh, S. S. and Toppozada, M. K. (1982). Transient luteolytic effect of Prostaglandins E2 in humans. Asia-Oceania J. Obstet. Gynaecol., 8, 413–417

    Article  PubMed  Google Scholar 

  • Rosenwaks, Z. and Jones, G. (1980). Menstrual pain: its origin and pathogenesis. J. Reprod. Med. 25 (Suppl. 4), 207–211

    PubMed  CAS  Google Scholar 

  • Roth-Brandel, V., Bygdeman, M. and Wiqvist, N. (1970). Effect of intravenous administration of Prostaglandin E1 and F2α on the contractility of the non-pregnant human uterus in vivo. Acta Obstet. Gynecol. Scand., 49, (Suppl. 5), 19–41

    Article  Google Scholar 

  • Russell, W. (1975). Luteolysis induced in pigtail monkeys (Macaca nemestrina) with pros-taglandin F2α ICI 80996 and ICI 81008. Prostaglandins, 10, 163–183

    PubMed  CAS  Google Scholar 

  • Saleh, A. (1982). Effect of thromboxane B2 on the non-pregnant human uterus. M.S. thesis. The University of Alexandria, Egypt

    Google Scholar 

  • Salem, A. I. S. (1982). Effect of Prostaglandins and their synthesis inhibitors on uterine activity in primary dysmenorrhoea. M.D. thesis, The University of Alexandria, Egypt

    Google Scholar 

  • Schick, B. (1920). Das menstruationsgift. Wien Klin. Wochenschr., 19, 1. Quoted by Pickles, V. R. (1978). Prostaglandins and dysmenorrhoea, Acta Obstet. Gynecol., Suppl. 87, 7–12

    Google Scholar 

  • Shaala, S., Gaafar, A. and Toppozada, M. (1974). Response of the menopausal uterus to Prostaglandins. In Toppozada, M. (ed.) Prostaglandins in Human Reproduction, pp. 95–102. ( Alexandria: Alexandria University Press )

    Google Scholar 

  • Shaala, S., Khowessah, M., El-Damarawy, H., El-Sahwi, S. and Toppozada, M. (1977). Reduced uterine response to PGF2α under oral contraceptives. Prostaglandins, 14, 523–533

    Article  PubMed  CAS  Google Scholar 

  • Shaala, S., El-Damarawy, H., Gaafar, T. E. and Toppozada, M. (1983). Effect of the main metabolite of prostacyclin on the contractility of the non-pregnant uterus, Prostaglandins, Leukotriens and Medicine (In press)

    Google Scholar 

  • Shaikh, A. A. (1972). Regulation of menstrual cycle and termination of pregnancy in the monkey by estradiol and PGF2α. Prostaglandins, 2, 227–233

    Article  PubMed  CAS  Google Scholar 

  • Shutt, D. A., Clarke, A. H., Fraser, I. S., Goh, P., McMahon, G. R., Saunders, D. M. and Shearman, R. P. (1976). Changes in concentration of Prostaglandin F and steroids in human corpora lutea in relation to growth of the corpus luteum and luteolysis. J. Endocrinol., 71, 453–456

    Article  PubMed  CAS  Google Scholar 

  • Sun, F. F., Chapman, J. P. and McGuire, J. C. (1977). Metabolism of Prostaglandin endoperoxide in animal tissues. Prostaglandins, 14, 1055–1074

    Article  PubMed  CAS  Google Scholar 

  • Svanborg, K., Bendvold, E., Bygdeman, M. and Eneroth, P. (1982). The relation between PGs in human seminal fluid and fertility. Int. Conference on PGs (Abst.) Florence, May 1982, p. 711

    Google Scholar 

  • Swanston, I. A., McNatty, K. P. and Baird, D. T. (1977). Concentration of Prostaglandin F2α and steroids in the human corpus luteum. J. Endocrinol., 73, 115–122

    Article  PubMed  CAS  Google Scholar 

  • Swahn, M. L. and Lundstrom, V. (1983). The effect of intravenous and intrauterine administration of prostacyclin on the non-pregnant uterine contractility in vivo. Acta Obstet Gynecol. Scand., Suppl. 113, 47–50

    Article  CAS  Google Scholar 

  • Tom, W. K. C., Thorneycroft, J. H., Nakamura, R. M. and Mishell, D. R. Jr (1972). Intravaginal PGF2α as a luteolytic agent. Advanced abstracts, p. 110. International Conference on Prostaglandins, Vienna, September 1972. ( Oxford: Pergamon Press Vieweg )

    Google Scholar 

  • Toppozada, M. (1975). Letter to the editor. Prostaglandins, 10, 725

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M. and Hafez, E. S. E. (1980). The role of Prostaglandins in the mechanism of action and side-effects of IUD. In E. S. E. Hafez and Van Os, W. A. A. (eds). Medicated Intrauterine Devices, pp. 84–98. ( Amsterdam: Martinus Nijhoff )

    Chapter  Google Scholar 

  • Toppozada, M., Gaafar, A. and Shaala, S. (1974a). In vivo inhibition of the human non-pregnant uterus by Prostaglandin E2. Prostaglandins, 8, 401–410

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M., Beguin, F., Bygdeman, M. and Wiqvist, N. (1972). Response of the midpregnant human uterus to systemic administration of 15 (s) methyl PGF2α. Prostaglandins, 2, 239–249

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M., Rizk, M. A. and El-Agouz, W. (1974b). Corpus luteum demise by Prostaglandin F2α In Toppozada, M. (ed.) Prostaglandins in Human Reproduction, pp. 85–93. ( Alexandria: Alexandria University Press )

    Google Scholar 

  • Toppozada, M., Gaafar, A., Shaala, S. and Osman, M. (1975). The relaxant property of local Prostaglandin E2 on the non-pregnant uterus –A cyclic triphasic response. Prostaglandins, 9, 475–486

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M., Khowessah, M., Shaala, S., Said, S. and Osman, M. (1976). Uterine response to Prostaglandin E2 under oral contraceptives. Contraception, 13, 749–761

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M., Khowessah, M., Shaala, S., Osman, M. and Rahman, H. A. (1977). Aberrant uterine response to Prostaglandin E2 as a possible etiologic factor in functional infertility. Fertil. Steril., 28, 434–439

    PubMed  CAS  Google Scholar 

  • Toppozada, M., Khalil, T. H. and El-Sokkary, H. (1978). The role of Prostaglandins in the control of human pituitary ovarian function. Proc. 6th. Asia and Oceania Congress of Endocrinology, pp. 143–151. 22–27 January Singapore

    Google Scholar 

  • Toppozada, M., El-Abd, M., El-Sokkary, H., El-Rahman, H. A., Khalil, T. H. and Galal, R. (1979). Effect of a Prostaglandin inhibitor on human ovulation. Sing. J. Obstet. Gynaecol., 10, 42–46

    CAS  Google Scholar 

  • Toppozada, M., Rizk, M., Thabet, M. H. and Shaala, S. (1980). Uterine response to PGE2 with IUDs: a possible mechanism of action and side-effects. Contracept. Deliv. Syst., 1, 349–361

    PubMed  CAS  Google Scholar 

  • Toppozada, M., El-Sokkary, H., El-Abd, M., El-Fazary, A. and El-Rahman, H. (1981). Induction of human luteolysis by high dose infusions of 15-methyl PGF2α. Prostaglandins Med., 6, 203–211

    Article  PubMed  CAS  Google Scholar 

  • Toppozada, M., Shaala, S., Saleh, A. and Damarawy, H. (1983). Effect of thromboxane B2 on the contractility of the non-pregnant human uterus. Prostaglandins, Leukotriens Med. (In press)

    Google Scholar 

  • Virutamasen, P., Wright, K. H. and Wallach, E. E. (1972). Effects of catecholamines on ovarian contractility in the rabbit. Obstet. Gynecol., 39, 225–236

    PubMed  CAS  Google Scholar 

  • Virutamasen, P., Wright, K. H. and Wallach, E. E. (1973). Monkey ovarian contractility — its relationship to ovulation. Fertil. Steril., 24, 763–771

    PubMed  CAS  Google Scholar 

  • Wallach, E. E., de la Cruz, A., Hunt, J., Wright, K. and Stevens, V. C. (1975a). The effect of indomethacin on HMG-HCG induced ovulation in the rhesus monkey. Prostaglandins, 9, 645–658

    Article  PubMed  CAS  Google Scholar 

  • Wallach, E. E., Bronson, R., Hamada, Y., Wright, K. and Stevens, V. C. (1975b). Effectiveness of PGF2α in restoration of HMG-HCG induced ovulation in indomethacin treated rhesus monkeys. Prostaglandins, 10, 129–138

    PubMed  CAS  Google Scholar 

  • Wentz, A. C. and Jones, G. S. (1972). Effect of infused PGF2α on human corpus luteum function and menses. Brook Lodge Symposium on Prostaglandins. (Abst.) June 1972, p. 47

    Google Scholar 

  • Wentz, A. C. and Jones, G. S. (1973). Transient luteolytic effect of PGF2α in humans. Obstet. Gynecol., 42, 172–181

    PubMed  CAS  Google Scholar 

  • Wilhelmsson, L., Lindblom, B. and Wiqvist, N. (1979). The human uterotubal junction. Contractile patterns of different smooth muscle layers and influence of PGE2, PGF2α and PGI2 in vitro. Fertil. Steril., 32, 303–307

    PubMed  CAS  Google Scholar 

  • Wilhelmsson, L. (1981). Biological actions of Prostaglandins on different tissues within the non-pregnant human uterus. M.D. thesis. Department of Obstetrics and Gynecology, University of Göteborg, Sweden, pp. 1–44

    Google Scholar 

  • Wilhelmsson, L., Wikland, M. and Wiqvist, N. (1981). PGH2, Tx A2 and PGI2 have potent and differentiated actions on human uterine contractility. Prostaglandins, 21, 277–286

    Article  PubMed  CAS  Google Scholar 

  • Wiqvist, N. and Wilhelmsson, L. (1979). Some clinical and theoretical aspects on Prostaglandins in Obstetrics and Gynecology. Gynecol. Obstet. Invest., 10, 1–8

    Article  PubMed  CAS  Google Scholar 

  • Wiqvist, N., Bygdeman, M. and Kirton, K. T. (1971). Non-steroidal antifertility agents in the female. In Diczfalusy, E. and Borell, U. (eds.). Nobel Symposium 15: Control of Human Fertility. pp. 137–155. ( Stockholm: Almqvist & Wiksell )

    Google Scholar 

Download references

Authors
  1. M. K. Toppozada
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Alexandria, Egypt

    M. K. Toppozada

  2. Department of Obstetrics and Gynecology, Karolinska Hospital, 10401, Stockholm 60, Sweden

    M. Bygdeman

  3. Department of Physiology, Reproductive Health Center, Medical University of South Carolina, 171 Ashley, Charleston, SC, 29455, USA

    E. S. E. Hafez

Rights and permissions

Reprints and permissions

Copyright information

© 1984 MTP Press Limited

About this chapter

Cite this chapter

Toppozada, M.K. (1984). Effects of prostaglandins on the human non-pregnant uterus and ovary. In: Toppozada, M.K., Bygdeman, M., Hafez, E.S.E. (eds) Prostaglandins and Fertility Regulation. Advances in Reproductive Health Care, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5600-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-5600-1_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8969-2

  • Online ISBN: 978-94-009-5600-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation