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Antibodies pp 37–66Cite as

Antibody—antigen interaction

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Abstract

Perhaps the most important function of antibody molecules is to combine with the corresponding antigen to form an antibody—antigen complex which is then eliminated from the circulation by the cells of the mononuclear phagocytic system. The specific interaction of antibody with the antigen involves the interaction of the antigen binding site, (which is comprised of the hypervariable regions of both heavy and light chains), with the antigenic determinant.

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References

  1. Karush, F. (1962), Advan. Immunol., 2, 1.

    Article  CAS  Google Scholar 

  2. Gill, T. J. III (1970), Immunochemistry, 7, 99.

    Article  Google Scholar 

  3. Farr, R. S. and Minden,P. (1968), Ann. NY Acad. Sci., 154, 107.

    Article  PubMed  CAS  Google Scholar 

  4. Minden, P., Anthony, B. F. and Farr, R. S. (1968), J. Immunol., 102,832.

    Google Scholar 

  5. Heidelberger, M. and Kendall, F. E. (1929), J. Exp. Med., 50, 809.

    Article  PubMed  CAS  Google Scholar 

  6. Heidelberger, M. (1939), Bact. Rev., 3,49.

    PubMed  CAS  Google Scholar 

  7. Marrack, J. R. (1938), The Chemistry of Antigen and Antibodies, HMSO, London.

    Google Scholar 

  8. Moller, N. P. H. and Steensgaard, J. (1979), Immunol., 38, 641.

    CAS  Google Scholar 

  9. Hornick, C. L. and Karush, F. (1972), Immunochemistry, 9, 325.

    Article  PubMed  CAS  Google Scholar 

  10. Stanley, C., Lew, A. M. and Steward, M. W. (1983), J. Immunol. Meths. (in press).

    Google Scholar 

  11. Day, E. D. (1972), Advanced Immunochemistry, Williams and Wilkins, Baltimore, p. 181.

    Google Scholar 

  12. Steward, M. W. and Steensgaard, J. (1983), Antibody Affinity: Thermodynamic Aspects and Biological Significance, CRC Press, Boca Raton, Florida.

    Google Scholar 

  13. Sips, R. (1948), J.Chem. Phys., 16,490.

    Article  CAS  Google Scholar 

  14. Nisonoff, A. and Pressman, D. (1956), J. Immunol., 80, 417.

    Google Scholar 

  15. Steward, M. W. and Petty, R. E. (1972), Immunology, 22, 747.

    PubMed  CAS  Google Scholar 

  16. Eisen, H. N. and Siskind, G. W. (1964), Biochemistry, 3, 966.

    Article  Google Scholar 

  17. Pressman, D., Roholt, D. A. and Grossberg, A. L. (1970), Ann. NY Acad. Sci., 169,65.

    Article  PubMed  CAS  Google Scholar 

  18. Werblin, T. and Siskind, G. W. (1972), Immunochem., 9, 987.

    Article  CAS  Google Scholar 

  19. Steward, M. W. (1978), in Handbook of Experimental Immunology (ed. D. M. Weir), 3rd edn, Blackwell, Oxford, p. 161.

    Google Scholar 

  20. Eisen, H. N. (1964), Methods in Medical Research, 10, 106.

    PubMed  CAS  Google Scholar 

  21. Farr, R. S. (1958), J.Infect. Dis., 103, 239.

    Article  PubMed  CAS  Google Scholar 

  22. Stupp, V., Joshida, T. and Paul, W. E. (1969), J. Immunol., 103, 624.

    Google Scholar 

  23. Steward, M. W. and Petty, R. E. (1972), Immunol., 23, 881.

    CAS  Google Scholar 

  24. Velick, S. F., Parker, C. W. and Eisen, H. N. (1960), Proc. Nat. Acad. Sci. (Wash.), 46, 1470.

    Article  CAS  Google Scholar 

  25. Parker, C. W. (1973), in Handbook of Experimental Immunology (ed. D. M. Weir), 2nd edn, Vol. 1, Blackwell, Oxford, p. 14.

    Google Scholar 

  26. Parker, C. W., Yoo, T. J, Johnson, M. C. and Colt, S. M. (1967), Biochemistry, 6, 3408.

    Article  PubMed  CAS  Google Scholar 

  27. Dandliker, W., Schapiro, H. C., Meduski, J. W., Alonso, R., Feigen, G. A. and Hamrick, J. R. Jnr. (1964), Immunochem., 1, 165.

    Article  CAS  Google Scholar 

  28. Normansell, D. E. (1970), Immunochemistry, 7, 787.

    Article  PubMed  CAS  Google Scholar 

  29. Stone, M. J. and Metzger, H. (1969), J. Biol Chem., 243, 5049.

    Google Scholar 

  30. Steward, M. W., Turner, M. W., Natvig, J. B. and Gaarder, P. I. (1973), Clin. Exp. Immunol., 15, 145.

    PubMed  CAS  Google Scholar 

  31. Anderson, B. (1970), J. Exp. Med., 132, 77.

    Article  Google Scholar 

  32. Jerne, N. K. and Nordin, A. A. (1963), Science, 140, 405.

    Article  Google Scholar 

  33. Talmage, D. (1960), J. Infect. Dis.,107, 115.

    Article  PubMed  CAS  Google Scholar 

  34. Smith, T. W. and Skubitz, K. M. (1975), Biochemistry, 14, 496.

    Google Scholar 

  35. Chance, B. (1963), in Techniques in Organic Chemistry Part 3 (ed. A. Weissberged), Vol. 8, Interscience, New York.

    Google Scholar 

  36. Froese, A., Sehon, A. H. and Eigen, M. (1962), J. Chem., 40, 178.

    Google Scholar 

  37. Skubitz, K. M. and Smith, T. W. (1975), J. Immunol., 114, 369.

    Google Scholar 

  38. Froese, A., (1968),Immunochem., 5, 253.

    Article  CAS  Google Scholar 

  39. Morgan, A. G. and Soothill, J. F. (1975), Nature (Lond.), 254, 711.

    Article  CAS  Google Scholar 

  40. De Kruyff, R. and Siskind, G. W. (1979), Cell Immunol., 47, 134.

    Article  Google Scholar 

  41. De Kruyff, R. and Siskind, G. W. (1980), Cell Immunol., 49, 90.

    Article  Google Scholar 

  42. Petty, R. E. and Steward, M. W. (1977), Immunol., 32, 49.

    CAS  Google Scholar 

  43. Soothill, J. F. and Steward, M. W. (1971), Clin. Exp. Immunol., 9, 193.

    PubMed  CAS  Google Scholar 

  44. Steward, M. W. and Petty, R. E. (1976), Immunology, 30, 789.

    PubMed  CAS  Google Scholar 

  45. Katz, F. E. and Steward, M. W. (1975), Immunology, 29, 543.

    PubMed  CAS  Google Scholar 

  46. Reinhardt, M. C. and Steward, M. W. (1979), Immunology,38, 735.

    PubMed  CAS  Google Scholar 

  47. Steward, M. W., Alpers, J. H. and Soothill, J. F. (1913), Proc. Roy. Soc. Med., 66, 808.

    Google Scholar 

  48. Pattison, J., Steward, M. W. and Targett, G. A. T. (1983), Clin.Exp. Immunol., 53, 175.

    PubMed  CAS  Google Scholar 

  49. Steiner, L. A. and Eisen, H. N. (1967), J. Exp. Med., 126, 1161.

    Article  PubMed  CAS  Google Scholar 

  50. Perelson, A. S. (1978), in Theoretical Immunology, Vol. 8, Marcel Dekker, New York, p. 171.

    Google Scholar 

  51. Edberg, S. C., Bronson, P. M. and Van Oss, C. J. (1972), Immunochemistry, 9, 273.

    Article  PubMed  CAS  Google Scholar 

  52. Blank, S. E., Leslie, G. A. and Clem, L. W. (1972), J. Immunol, 108, 665.

    PubMed  CAS  Google Scholar 

  53. Alpers, J. H., Steward, M. W. and Soothill, J. F. (1972), Clin. Exp. Immunol, 12, 121.

    PubMed  CAS  Google Scholar 

  54. Fauci, A. G., Frank, M. M. and Johnson, J. J. (1970), J. Immunol, 105, 215.

    PubMed  CAS  Google Scholar 

  55. Steward, M. W. (1979), Clin. Exp. Immunol., 38, 414.

    PubMed  CAS  Google Scholar 

  56. Devey, M.E. and Steward, M. W. (1980), Immunology, 41, 303.

    PubMed  CAS  Google Scholar 

  57. Steward, M. W. and Devey, M. E. (1982), in Immunological Aspects of Rheumatology (ed. W. C. Dick), Medical and Technical Press, Lancaster, p. 63.

    Google Scholar 

  58. Arnon, R. and Sela, M. (1969), Proc. Nat. Acad. Sci. (USA), 62, 163.

    Article  CAS  Google Scholar 

  59. Richards, F. F., Varga, J. M., Rosenstein, R. W. and Konigsberg, W. H. L. (1977), in Immunochemistry, An Advanced Textbook (eds L. E. Glynn and M. W. Steward), John Wiley, Chichester p. 59.

    Google Scholar 

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Authors and Affiliations

  1. London School of Hygiene and Tropical Medicine, UK

    M. W. Steward (Professor of Immunology)

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  1. M. W. Steward
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© 1984 M. W. Steward

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Steward, M.W. (1984). Antibody—antigen interaction. In: Antibodies. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5572-1_4

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  • DOI: https://doi.org/10.1007/978-94-009-5572-1_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-412-25640-0

  • Online ISBN: 978-94-009-5572-1

  • eBook Packages: Springer Book Archive

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