Abstract
The pharmacologist using a drug is interested initially in its action and then in the optimization of this action. It is sometimes easy to model the action, especially when there is a direct and linear relation to the concentration in the blood compartment [72]. In many cases the action of the drug cannot be related to the concentration in the blood by a simple model. This happens when sophisticated biochemical transformations arise [35]. In this chapter we shall describe some of the main difficulties.
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© 1986 D. Reidel Publishing Company, Dordrecht, Holland
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Cherruault, Y. (1986). Relations Between Dose and Effect. In: Mathematical Modelling in Biomedicine. Mathematics and Its Applications, vol 23. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5492-2_5
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DOI: https://doi.org/10.1007/978-94-009-5492-2_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8924-1
Online ISBN: 978-94-009-5492-2
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