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Regulators of Growth, Differentiation and the Reversal of Malignancy

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Interrelationship Among Aging, Cancer and Differentiation

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 18))

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Abstract

Identification of normal growth and differentiation factors and how they interact in normal development, made it possible to identify the mechanisms that uncouple growth and differentiation so as to produce malignant cells. When cells become malignant, the malignant phenotype can again be suppressed. Results on the reversibility of malignancy in different types of tumors have shown, that in addition to genes for the expression of malignancy (oncogenes) there are other genes (soncogenes) that can suppress the action of oncogenes, that reversion does not have to restore all the normal controls, and that the stopping of cell multiplication by inducing differentiation to mature cells can by-pass the genetic abnormalities that give rise to malignancy.

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Author information

Authors and Affiliations

  1. Department of Genetics, Weizmann Institute of Science, Rehovot, Israel

    Leo Sachs

Authors
  1. Leo Sachs
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  2. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

    Edmond L. Schneider

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© 1985 D. Reidel Publishing Company, Dordrecht, Holland

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Sachs, L. (1985). Regulators of Growth, Differentiation and the Reversal of Malignancy. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_5

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  • DOI: https://doi.org/10.1007/978-94-009-5466-3_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8913-5

  • Online ISBN: 978-94-009-5466-3

  • eBook Packages: Springer Book Archive

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