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Cellular Studies on the Interrelationship Among Cancer, Aging and Cellular Differentiation

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Interrelationship Among Aging, Cancer and Differentiation

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 18))

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Abstract

An experimental animal model and cellular system, based on the Syrian hamster (Mesocricetus auratus), has been developed for the study of the interrelationship among cancer, aging and differentiation. Using this system, we have identified a progenitor-like cell which is present in primary and low passage mesenchymal cell cultures. The loss or absence of these cell.s is correlated with reduced in vitro proliferative capacity (cellular senescence), reduced response to growth promoting factors, and reduced susceptibility to in vitro neoplastic transformation. Based on these studies we propose a hypothesis on the central role of stem cells and/or progenitor cells in the interrelationship among cancer, aging and cellular differentiation.

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Author information

Authors and Affiliations

  1. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, 21205, USA

    Sarah A. Bruce & Paul O. P. Ts’o

Authors
  1. Sarah A. Bruce
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  2. Paul O. P. Ts’o
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  2. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

    Edmond L. Schneider

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© 1985 D. Reidel Publishing Company, Dordrecht, Holland

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Bruce, S.A., Ts’o, P.O.P. (1985). Cellular Studies on the Interrelationship Among Cancer, Aging and Cellular Differentiation. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_31

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  • DOI: https://doi.org/10.1007/978-94-009-5466-3_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8913-5

  • Online ISBN: 978-94-009-5466-3

  • eBook Packages: Springer Book Archive

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