Abstract
An attempt is made to present evidence that there is a close relationship at the molecular level between biological events associated with oxidative metabolism that can lead to cell ageing and ultimate tumori-genesis. It is suggested that the common thread between these two gross biological events is the production of and lack of inhibition of labile oxygen radicals •O2 -and •OH. Evidence is presented that OH radicals are responsible for the initiation of lipid peroxidation which is associated with cell ageing and these same radicals maybe responsible for carcinogen activation or direct mutagenesis leading ultimately to tumorigenesis.
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References
ANISIMOV, V. N. and TURUSOV, V. S.: Modifying effect of ageing on chemical carcinogenesis. A Review Mechanism of Ageing and Development 15, 399, 1981.
EMANUAL, N. M.: Free radicals on the appearance and growth of tumors. In Free Radicals and Cancer. R. A. Floyd, editor. Marcel Dekker, Inc., New York (in press).
FRANKFURT, O. S., LYPCHINU, L. P., BUNTO, T. V. and EMANUAL, N. M.: Inhibition of carcinogenesis with antioxidants BHT. Exp. Biol. Med. 8, 163, 1967.
FRIDOVTTCH, I.: Free radicals in biology, Vol. I. W. A. Pryor, editor. Academic Press, New York, 1976, pp. 239–277.
HAMBOUR, J. R. and BOLTON, J. R.: Superoxide formation in spinach chloroplasts: ESR detection by spin trapping. Biochem. Biophys. Res. Commun. 64, 803–807, 1975.
HARMON, D. and PIETTE, L. H.: Free radical theory of ageing: Free radical reactions in serum. J. Gerontol. 21, No. 4, 560, 1966.
HOCHSTEIN, P. and ERNSTER, L.: APP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes. Biochem. Biophys. Res. Commun., 12, 388–394, 1963.
JANZEN, E. G. and BLACKBURN, B. J.: Detection and identification of shortlived free radicals by electron spin resonance trapping. Accts. Chem. Res. 4, 31–40, 1981.
KOMEDA, K. ONO, T. and IMAI, Y.: Participation of superoxide and OH radicals in NADPH-cytochrome P450 reductase catalyzed peroxidation of methyl linolenate. Biochem. Biophys. Acta. 572, 77–82, 1979.
LAI, C. S. and PIETTE, L. H.: Spin-trapping studies of OH radical production involved in lipid peroxidation. Arch. Biochem. Biophys. 190, 27–38, 1978.
PETO, R., DOLL, R., BUCKLEY, J. D., SPORN, M. B.: Nature (London) 290, 201, 1980.
SHAMBERGER, R. J., TYTKO, S. A. and WILLIS, C. E.: Malondialdehyde is a carcinogen. Fed. Proc. 34, 827, 1975.
SHULYAKOVSKAYA, T. A., SAPRIN, A. N. and EMANUAL, N. M.: Effects of chemical compounds with varying toxicity on the content of free radicals and microsomal system of non-specific oxidases in the liver of animals. Dokl. Akad. Nauk., U.S.S.R. 210,221–223, 1973.
TOTTER, J. R.: Spontaneous cancer and its possible relationship to oxygen metabolism. Proc. Natl. Acad. Sci. USA, 77, 1763–1767, 1980.
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© 1985 D. Reidel Publishing Company, Dordrecht, Holland
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Piette, L.H. (1985). Ageing and Cancer. A Common Free Radical Mechanism?. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_29
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DOI: https://doi.org/10.1007/978-94-009-5466-3_29
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