Abstract
A few in vitro mammalian cell models are available for investigating cellular and molecular mechanisms of chemical carcinogenesis and for determining the potential carcinogenicity of environmental chemicals. Although the results obtained with these models correlate well with results from lifetime studies with experimental animals and human epidemiological data, similar end points have not been obtained with human cells from normal sources or from individuals with inborn errors of metabolism associated with higher risks of malignancy. The results with human cells suggest that a difference in control mechanisms at the target cell level is responsible for “competence” that makes the cell susceptibile to transformation by a carcinogen. Contrary to rodent cells which are transformed by a variety of carcinogens, human cells subjected to the same carcinogens exhibit neither indefinite proliferation nor loss of growth control. Furthermore, the chromosomal defects found in human cells after carcinogen treatment are either not as extensive or lack the specific defect which is associated with indefinite proliferation or loss of growth control usually associated with mammalian cell transformation.
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© 1985 D. Reidel Publishing Company, Dordrecht, Holland
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DiPaolo, J.A., Doniger, J.N., Popescu, N.C. (1985). Comparison of Human and Rodent Cell Transformation by Known Chemical Carcinogens. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_24
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DOI: https://doi.org/10.1007/978-94-009-5466-3_24
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