Skip to main content
SpringerLink
Log in

The Conformational Effects of UV Induced Damage on DNA

  • Conference paper
Interrelationship Among Aging, Cancer and Differentiation

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 18))

Abstract

Energy minimization techniques are used in conjunction with the results of small molecule crystallographic studies on relevant compounds to propose structural models for photodamaged DNAs. Specifically, we present models both for a DNA molecule containing a psoralen photo-crosslink and for a DNA molecule containing a thymine photodimer. In both models, significant distortions of the nucleic acid helix are observed, including kinking and unwinding at the damage site and numerous changes in the backbone torsion angles relative to their standard conformations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ghio, C., Alagona, G., Profeta, S., Jr. & Weiner, P. (1984) J. Am. Chem. Soc. 106, 765–784.

    Article  CAS  Google Scholar 

  2. Kopka, M.L., Yoon, C, Goodsell, D., Pjura, P. and Dickerson, R.E. (1985) Proc. Natl. Acad. Sci. USA 82, 1376–1380.

    Article  CAS  Google Scholar 

  3. Pearlman, D. A., Holbrook, S. R., Pirkle, D. H. & Kim, S.-H. (1985) Science 227, 1304–1308.

    Article  CAS  Google Scholar 

  4. Wang, S. Y., Ed. (1976) Photochemistry and Photobiology of Nucleic Acids, Vol. I, Academic Press, New York.

    Google Scholar 

  5. Hearst, J. E. (1981) Ann. Rev. Biophys. and Bioengineer. 10, 69–86.

    Article  CAS  Google Scholar 

  6. Peckler, S., Graves, B., Kanne, D., Rapoport, H., Hearst, J. E. & Kim, S.-H. (1982) J. Mol. Biol. 162, 157–172.

    Article  CAS  Google Scholar 

  7. Weiner, P. K. & Kollman, P. K. (1981) J. Comp. Chem. 2, 287–303.

    Article  CAS  Google Scholar 

  8. Rao, S. N., Keepers, J. W. & Kollman, P. (1984) Nucl. Acids Res. 12, 4789–4807.

    Article  CAS  Google Scholar 

  9. Arnott, S. & Hukins, D. W. L. (1972) Biochem. Biophys. Res. Commun. 47, 1504–1509.

    Article  CAS  Google Scholar 

  10. Camerman, N. & Camerman, A. (1970) J. Am. Chem. Soc. 92, 2523–2527.

    Article  CAS  Google Scholar 

  11. Pearlman, D. A. & Kim, S.-H. (1985) Proceedings of the International Symposium on Biomolecular Structure and Interactions (in press).

    Google Scholar 

  12. Hruska, F. E., Wood, D. J., Ogilvie, K. K. & Charlton, J. L. (1975) Can. J. Chem. 53, 1193–1203.

    Article  CAS  Google Scholar 

  13. Haynes, R. H. (1964) Photochem. and Photobiol. 3, 429–450.

    Article  CAS  Google Scholar 

  14. Denhart, D. T. & Kato, A. C. (1973) J. Mol. Biol. 77, 479–494.

    Article  Google Scholar 

  15. Legerski, R. J., Grey, H. B., Jr. & Robberson, D. L. (1977) J. Biol. Chem. 252, 8740–8746.

    CAS  Google Scholar 

  16. Wang, T.-M. & McLaren, A. D. (1972) Biophysik 8, 237–244.

    Article  CAS  Google Scholar 

  17. Wiesehahn, G. & Hearst, J. E. (1978) Proc. Natl. Acad. Sci. USA 75, 2703–2707.

    Article  CAS  Google Scholar 

  18. Ciarrocchi, G. & Pedrini, A. M. (1982) J. Mol. Biol. 155, 177–183.

    Article  CAS  Google Scholar 

  19. Chatterjee, P. K. (1981) Ph.D. Thesis, Columbia University, New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemical Biodynamics Division, Lawrence Berkeley Laboratory & Department of Chemistry, University of California, Berkeley, CA, 94720, USA

    David A. Pearlman, Stephen R. Holbrook & Sung-Hou Kim

Authors
  1. David A. Pearlman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen R. Holbrook
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sung-Hou Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  2. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

    Edmond L. Schneider

Rights and permissions

Reprints and permissions

Copyright information

© 1986 D. Reidel Publishing Company, Dordrecht, Holland

About this paper

Cite this paper

Pearlman, D.A., Holbrook, S.R., Kim, SH. (1986). The Conformational Effects of UV Induced Damage on DNA. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-5466-3_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8913-5

  • Online ISBN: 978-94-009-5466-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation