Abstract
Cytoprotection in the stomach can be defined as the phenomenon that damage to the gastric mucosa by irritating agents can be prevented. Data will be outlined below to show that two different forms of cytoprotection exist:
-
1.
direct cytoprotection
-
2.
adapted cytoprotection
As prostaglandins play an important role in the concept of cytoprotection, a short outline is given of the structure of prostaglandins.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Smith GS, Warhurst G, Turnberg LA. Synthesis and degradation of prostaglandin E2 in the epithelial and sub-epithelial layers of the rat intestine. Bio-chim Biphys Acat 1982;713:684– 7.
Robert A, Nezamis JE, Phillips JP. Effect of prostaglandin E on gastric secretion and ulcer formation in the rat. Gastroenterology 1968; 55: 481.
Robert A, Kande G, Reele SB. Dose response inhibition in man of meal- stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally. Gut 1981; 22: 728–31.
Robert A. Antisecretory, antiulcer, cytoprotective and diarrhoegenic properties of prostaglandins. In: Samuelsson B, Paoletti R (Eds). New York, Raven Press 1957:507–20.
Cohen MM. Mucosal cytoprotection by prostaglandinm E2 Lancet 1978;2: 1253 –4.
Johansson C, Kollberg B, Nordemar R, Bergstrom S. Protection of gastrointestinal mucosa by E2 prostaglandins. Lancet 1979; 1: 317.
Johansson C, Kollberg B, Nordemar et al. Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Gastroenterology 1980; 78: 479.
Kachel G, Ruppin H, Hagel J et al. Gastrale Mikroblutung und Acetylsalicyl- saure. Dtsch Mediz Wochenschr 1983;108:1145– 7.
Lact ER, Ito S. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 1982;83:613–25.
Garner A, Heylings JR. Stimulation of alkaline secretion in amphibian- isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2a. A proposed explanation for some of the cytoprotective actions of prostaglandins. Gastroenterology 1979;76:497– 503.
Johansson C, Aly A, Nilsson E, Flemstrom G. Stimulation of bicarbonate secretion by E2 prostaglandins in man. In: Samuelsson B, Paoletti R, Ram- well P (Eds). Advances in prostaglandin, Thromboxane, and Leukotriene Research. New York, Raven Press 1983: 395–401.
Feldman M, Barnett CC. Gastric bicarbonate secretion in humans. Effects of pentagastrin, betanechol and 11,16,16-trimethyl prostaglandin E2. J Clin Invest 1983;72:295–303.
Rees WDW, Gibbons LC, Warhurst G, Turnberg LA. Studies of bicarbonate secretion by the normal human stomach in vivo effect of aspirin, sodium tauro- cholate and prostaglandin Er In: Allan A, Flemstrom G, Garner A (Eds). Mechanism of mucosal protection in the upper gastrointestinal tract. New York, Raven Press 1983: 119–23.
Bickel M, Kauffman GL. Gastric mucus gel thickness: effect of distension, 16,16-dimethyl prostaglandin E2 and carbonoxolon. Gastroenterology 1981;80:770– 5.
Johansson C, Kollberg B. Stimulation by intragastrically administered E2 prostaglandin on humans mucus output. Eur J Clin Invest 1979; 9: 229–32.
Domschke W, Domschke S, Hornig D, Demmling L. Prostaglandin stimulated gastric mucus secretion in man. Acata hepatogastroenterol 1978;25:292 –4.
Guth PH. The role in mucosal blood flow in the pathogenesis and healing of peptic ulcer. In: Nelis GF, Boeve J, Misiewicz JJ (Eds). Peptic ulcer disease: basic and clinical aspects. Dordrecht, Martinus Nijhoff 1985:271 –84.
Mueller P, Fischer N, Kather H, Simon B. Prevention of aspirin-induced drop in gastric potential difference with 16,16-dimethyl prostaglandin E2. Lancet 1981;1:333 –4.
Tijtgat GNJ. Medical treatment of peptic ulcer with prostaglandins. In: Nelis GF, Boeve J, Misiewicz JJ (Eds). Peptic ulcer disease: basic and clinical aspects. Dordrecht, Martinus Nijhoff 1975:143 –53.
Ruppin H, Person B, Robert A, Domschke W. Gastric cytoprotection in man by prostaglandin E2. Scand J Gastroenterol 1981; 16: 647–52.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Robert, A. (1985). Cytoprotection and adapted cytoprotection. In: Nelis, G.F., Boevé, J., Misiewics, J.J. (eds) Peptic Ulcer Disease: Basic and Clinical Aspects. Developments in Gastroenterology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5034-4_23
Download citation
DOI: https://doi.org/10.1007/978-94-009-5034-4_23
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8730-8
Online ISBN: 978-94-009-5034-4
eBook Packages: Springer Book Archive