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Radiolabelled Schiff Bases in Brain Studies

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Progress in radiopharmacology 1985

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 9))

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Abstract

The development of Tc99m -radiopharmaceuticals for positive brain scanning is today one of the main goals of radiopharmacy (1,2). The ability of a drug to penetrate the blood brain barrier (BBB) depends on different factors (3,4). High lipophylicity combined with low protein affinity is demanded to ensure that a substance is able to leave blood-stream and enter the lipid of the endothelial cell plasma membranes (4,5). Different chemical structures have been tested (2) for the preparation of Tc99m-radiopharmaceuticals that would fulfill the above demands.

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References

  1. Oldendorf WH, Need for new radiopharmaceuticals. J. nucl. Med. 19: 1182, 1978.

    PubMed  CAS  Google Scholar 

  2. Loberg MD, Corder EH, Fields AT, Callery PS, Membrane transport in Tc-99m-labelled radiopharmaceuticals. I. Brain uptake by passive transport. J. nucl. Med. 20: 1181, 1979.

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  3. Oldendorf WH, Lipid solubility and drug penetration of the blood-brain barrier. Proc. Soc. exp. Biol. Med. 147: 813, 1974.

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  4. Oldendorf WH, Blood-brain barrier permeability to drugs. Ann. Rev. Pharm. 14: 239, 1974.

    Article  CAS  Google Scholar 

  5. Kung HF, Blau M, Regional intracellular pH shift: A proposed new mechanism for radiopharmaceutical uptake in brain and other tissues. J. nucl. Med. 21: 147, 1980.

    PubMed  CAS  Google Scholar 

  6. Uszler MJ, Bennett LR, Mena I, Oldendorf WH, Human CNS, Perfusion scanning with 123I-iodoantipyrine. Radiology 115: 197, 1975.

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Authors
  1. A. D. Varvarigou
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  2. E. Chiotellis
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  3. G. Evagelatos
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Rotterdamsch Radio-Therapeutisch Instituut, Rotterdam, The Netherlands

    Peter H. Cox

  2. Department of Nuclear Medicine, Health House, National Bank of Greece, Athens, Greece

    George Limouris

  3. Department of Nuclear Medicine, Groningen University Hospital, Groningen, The Netherlands

    Martin G. Woldring

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Varvarigou, A.D., Chiotellis, E., Evagelatos, G. (1985). Radiolabelled Schiff Bases in Brain Studies. In: Cox, P.H., Limouris, G., Woldring, M.G. (eds) Progress in radiopharmacology 1985. Developments in Nuclear Medicine, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5028-3_8

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  • DOI: https://doi.org/10.1007/978-94-009-5028-3_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8727-8

  • Online ISBN: 978-94-009-5028-3

  • eBook Packages: Springer Book Archive

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