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New Agents for Probing Glucose Turnover and Receptor Densities in the Brain

  • Chapter
Book cover Progress in radiopharmacology 1985

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 9))

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Abstract

In vivo functional imaging of the brain has, in contrast to that of other organs like heart or liver, only developed in the last decade. This is mainly due to a special feature of brain physiology, namely the blood-brain-barrier (BBB). BBB selectively restricts the access to the brain of most non-lipophilic substances borne in blood; only a relatively small number of vital substrates are transported into the brain by specialized carrier system. Thus, most of the radio-pharmaceuticals available in the early days of nuclear medicine were excluded from the brain. Only in areas with a destroyed BBB (some tumours etc) was it possible to observe measurable concentrations e.g. of Tc99m-compounds (1). This situation has dramatically changed recently with the application of metabolic tracers or analogs labelled with short-lived “organic” radionuclides. These radionuclides that form stable covalent binds to carbon, either the positron emitters 11C (T1/2= 98 min), 18F (T1/2= 110 min) and 75Br (T1/2= 98 min) or the single photon emitter 123I (T1/2= 13.3 h) can be introduced into most of the compounds important for the characteristic metabolism or function of the brain with acceptable alterations in their physico-chemical behaviour (2). They also lend themselves to 3-dimensional imaging, the positron emitters to positron-emission computed tomography (PECT) and the single photon emitters to single photon emission computed tomography (SPECT).

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Authors
  1. G. Kloster
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  2. G. Stöcklin
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Rotterdamsch Radio-Therapeutisch Instituut, Rotterdam, The Netherlands

    Peter H. Cox

  2. Department of Nuclear Medicine, Health House, National Bank of Greece, Athens, Greece

    George Limouris

  3. Department of Nuclear Medicine, Groningen University Hospital, Groningen, The Netherlands

    Martin G. Woldring

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Kloster, G., Stöcklin, G. (1985). New Agents for Probing Glucose Turnover and Receptor Densities in the Brain. In: Cox, P.H., Limouris, G., Woldring, M.G. (eds) Progress in radiopharmacology 1985. Developments in Nuclear Medicine, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5028-3_6

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  • DOI: https://doi.org/10.1007/978-94-009-5028-3_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8727-8

  • Online ISBN: 978-94-009-5028-3

  • eBook Packages: Springer Book Archive

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