Skip to main content
SpringerLink
Log in

Drug-Free High-Quality Tumour Imaging with 67Ga

  • Chapter
Progress in radiopharmacology 1985

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 9))

  • 28 Accesses

Abstract

In the preface to the book “Therapeutic Use of Artificial Radioisotopes”, P.F. Hahn wrote (1) in 1956: “Ideally, one looks for an agent that will seek out and destroy cancer”. 13 Years later in 1969, Edwards and Hayes (2) reported “Tumour scanning with 67Ga citrate”. In 1971 Hart and co-workers observed antitumour activity of gallium nitrate in rodents and suggested the potential usefulness of gallium for treatment of various solid tumours in man (3,4). During the last 15 years since the report of Edwards and Hayes (2), much effort has been devoted to improve the tumour imaging results with 67Ga and also to get satisfactory treatment of various tumours in rodents with gold gallium (5). Although 67Ga citrate is widely used for tumour (6) and abscess detection (7), a positive finding is often doubtful due to following difficulties still encountered during radionuclidic examinations with this radiopharmaceutical (8,9).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hahn PF, In: Therapeutic use of artificial radioisotopes, Hahn PF, (ed), John Wiley & Sons, Inc, New York, 1956.

    Google Scholar 

  2. Edwards CL, Hayes RL, Tumour imaging with 67Ga citrate. J. nucl. Med. 10: 103, 1969.

    PubMed  CAS  Google Scholar 

  3. Hart MM, Adamson RH, Antitumour activity and toxicity of salts of inorganic group IIIA metals aluminum, gallium, indium and thallium. Proc. nat. Acad. Sci. USA, 68: 1623, 1971.

    Article  PubMed  CAS  Google Scholar 

  4. Hart MM, Smith CF, Yancey ST, Adamson RH, Toxicity and anti tumour activity of gallium nitrate and periodically related metal salts. J. Nat. Cancer Inst. 47: 1121, 1971.

    PubMed  CAS  Google Scholar 

  5. Warrel Jr, RP, Coonley CJ, Straus DJ, Young CW, Treatment of patients with advanced malignant lymphoma using gallium nitrate administered as a seven day continuous infusion. Cancer 51: 1982, 1983.

    Article  Google Scholar 

  6. Keller F, Maiga MK, Koeppe P, 67Gallium kinetics in blood of patients with malignant tumours. Nucl. Med. 22: 155, 1983.

    CAS  Google Scholar 

  7. Oberhaensli RD, Mueller RM, Fridrich R, Different actions of deferoxamine and iron on Ga-67 abscess detection in rats. J. nucl. Med. 25: 668, 1984.

    PubMed  CAS  Google Scholar 

  8. Larson SM, Mechanism of localization of Gallium-67 in tunours. Sem. Nucl. Med. 8: 193, 1978.

    Article  CAS  Google Scholar 

  9. Shukla SK, Castelli L, Cipriani C, Manni GB, What is good in gallium-67 citrate and hew to increase its tumour affinity? Radioakt. Isot. Klin. Forsch. 14: 179, 1980.

    Google Scholar 

  10. Russian LD, Staab EV, Radionuclide imaging of intestinal infarction. Radiology 122: 171, 1977.

    Google Scholar 

  11. Levitt RG, Riello DR, Sagel SS, Stanley RJ, Aronberg DJ, Robinson ML, Siegel BA, Computed tomography and 67Ga citrate radionuclide imaging for evaluating suspected abdominal abscess. Amer. J. Roentgenol. 132: 529, 1979.

    CAS  Google Scholar 

  12. Beal WH, Chaudhury TK, One week post-injection gallium-67 scan is it of any added advantage ? J. nucl. Med. 19: 733, 1978.

    Google Scholar 

  13. Hoffer PB, The utility of gallium-67 in tumour imaging: A comment on the final reports on the co-operative study group. J. nucl. Med. 19: 1082, 1978.

    PubMed  CAS  Google Scholar 

  14. Kaplan HS, Hodgkin’s disease: Multidisciplinary contributions to the conquest of a neoplasm. Radiology 123: 551, 1977.

    PubMed  CAS  Google Scholar 

  15. Hayes RL, Byrd BL, Rafter JJ, Carlton JE, The effect of scandium on the tissue distribution of Ga-67 in normal and tumour-bearing rodents. J. nucl. Med. 21: 361, 1980.

    PubMed  CAS  Google Scholar 

  16. Hagan PL, Halpern SE, Stern P, Dabbs J, Gordon R, The effect of certain variables on the tumour and tissue distribution of tracers, II. Carrier effect: rapidity of onset and concentrations necessary for initiation and maximum response. Invest. Radiol. 15: 496, 1980.

    Article  PubMed  CAS  Google Scholar 

  17. Higashi T, (private communication on 6–7-1984).

    Google Scholar 

  18. Hayes RL, Byrd BL, Carlton JE, Rafter JJ, Factors affecting the localization of 67Ga in animal tumours. J. nucl. Med. 11: 324, 1970.

    Google Scholar 

  19. Higashi T, Nakayama Y, Akiba C, Ito K, Hisada T, Miki T, Kawai K, Diagnosis of malignant tumours with 67ca citrate, Japanese. J. nucl. jyfed. 8: 155, 1971.

    Google Scholar 

  20. Halpern SE, Hagan PL, Chauncey D, McKegney M, Bernstein K, The effect of certain variables on the tumour and tissue distribution of tracers. Part I. Carrier, Invest. Radiol. 14: 482, 1979.

    CAS  Google Scholar 

  21. Stern PH, Halpern SE, Hagan PL, Chen A, The effect of certain variables on the tumour and tissue distribution of tracers VI. False-carrier effect, Part III, Fe, Invest. Radiol. 17: 386, 1982.

    CAS  Google Scholar 

  22. Hayes RL, Edwards CL, The effect of stable scandium on red blood cells and on the retention and excretion of 67Ga in humans. South Med. 66: 1339, 1973.

    Article  Google Scholar 

  23. Hill JH, Merz T, Wagner Jr, HH,. Iron-indiced enhancement of 67Ga uptake in a model human leukocyte culture system. J. nucl. Med. 16: 1183, 1975.

    PubMed  CAS  Google Scholar 

  24. Muranaka A, Ito Y, Saito J, Otsuka N, Nagai K, Role of FeCl3 in 67Ga uptake by HeLa S3 cells in vitro. Eur. J. Nucl. Med. 8: 408, 1983.

    Article  PubMed  CAS  Google Scholar 

  25. Hoffer PB, Samuel A, Bushberg JT, Thakur M, Desferoxamine mesylate (desferal): A contrast enhancing agent for gallium-67 imaging. Radiology 131: 775, 1979.

    PubMed  CAS  Google Scholar 

  26. Oster ZH, Som P, Sacker DF, Atkins HL, The effects of desfroxamine mesylate on gallium-67 distribution in normal and abscess-bearing animals: Concise communication. J. nucl. Med. 21: 421, 1980.

    PubMed  CAS  Google Scholar 

  27. Sephton RG, Martin JJ, Modification of distribution of gallium-67 in man by administration of iron. Brit. J. Radiol. 53: 572, 1980.

    Article  PubMed  CAS  Google Scholar 

  28. Smith FW, Dendy PP, Modification of gallium-67 citrate distribution in man following the distribution of iron. Brit. J. Radiol. 54: 398, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Sephton RG, De Abrew S, Hodgson, mechanisms of distribution of gallium-67 in mouse tumour hosts. Brit. J. Radiol. 55: 134, 1982.

    Article  PubMed  CAS  Google Scholar 

  30. Hagan PL, Halpern SE, Stern P, Dabbs J, Gordon R, The effect of certain variables on the tumour and tissue distribution of tracers, IV. False carrier: ferric citrate. Invest. Radiol. 16: 229, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Hagan PL, Halpern SE, Stern PH, Gordon RM, Dabbs JE, The effect of certain variables on the tumour and tissue distribution of tracers V. False carrier effect, II, Fe, Invest. Radiol. 17: 53, 1982.

    CAS  Google Scholar 

  32. Oster ZH, Larson SM, Wagner Jr, HN, Possible enhancement of 67Ga-citrate imaging by iron dextran. J. nucl. Med. 17: 356, 1976.

    PubMed  CAS  Google Scholar 

  33. Larson SM, Mahler D, Allen DR, Iron-dextran enhancement of 67Ga-concentration in abscess relative to normal tissue. Nucl. Med. 17: 95, 1978.

    CAS  Google Scholar 

  34. Shukla SK, Cipriani C, Manni GB, Castelli L, Increasing the tumour specificity of 67Ga-radiopharmaceuticals. J. Lab. Corp. Radiopharm. 16: 192, 1979.

    Google Scholar 

  35. Castelli L, Blotta I, Shukla SK, Cipriani C, Manni GB, Sul meccanismo di captazione des gallio-67 nei tumori. Radiol. Med. 69: 103, 1983.

    Google Scholar 

Download references

Authors
  1. S. K. Shukla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Blotta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Cipriani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. B. Manni
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Rotterdamsch Radio-Therapeutisch Instituut, Rotterdam, The Netherlands

    Peter H. Cox

  2. Department of Nuclear Medicine, Health House, National Bank of Greece, Athens, Greece

    George Limouris

  3. Department of Nuclear Medicine, Groningen University Hospital, Groningen, The Netherlands

    Martin G. Woldring

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Shukla, S.K., Blotta, I., Cipriani, C., Manni, G.B. (1985). Drug-Free High-Quality Tumour Imaging with 67Ga. In: Cox, P.H., Limouris, G., Woldring, M.G. (eds) Progress in radiopharmacology 1985. Developments in Nuclear Medicine, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5028-3_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-5028-3_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8727-8

  • Online ISBN: 978-94-009-5028-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation