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New perspectives on the kinetics of mononuclear phagocytes

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Mononuclear Phagocytes

Abstract

During the last twenty years the origin and kinetics of macrophages and monocytes have been studied in great detail. This research can now be seen to have followed a certain line. First, studies with chimeras provided indications that macrophages originated in the bone marrow (1). Next, studies with labelled cells showed that the peritoneal macrophages involved in acute inflammatory response derived from circulating blood monocytes originating in the bone marrow (2–6). It was then found that in the normal steady state the peritoneal macrophages also arise from blood monocytes, and the kinetics of the blood monocytes and peritoneal macrophages were described (7). Later, the same was done for Kupffer cells (8), pulmonary macrophages (9, 10), and quite recently for spleen macrophages (11).

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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van Furth, R., Diesselhoff-den Dulk, M.M.C., Sluiter, W., van Dissel, J.T. (1985). New perspectives on the kinetics of mononuclear phagocytes. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_21

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  • DOI: https://doi.org/10.1007/978-94-009-5020-7_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8723-0

  • Online ISBN: 978-94-009-5020-7

  • eBook Packages: Springer Book Archive

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