Abstract
In bone marrow, an intact system of vascular sinuses and fibroblastic stroma has been shown to be the structural basis necessary for hemopoietic activity under physiologic (1, 2) and pathologic (3) conditions. The predominant cells of this hemopoietic microenvironment are believed to be reticulum cells which expand a three-dimensional network (reticulum) of cytoplasmic extensions throughout the marrow parenchyma (4). It is generally agreed, however, that the term reticulum (reticular) cell might include several cell types that have not yet been precisely characterized (5). So far, two main types of reticulum cells have been distinguished in the rodent bone marrow by electron microscopy: a nonphagocytic reticulum cell (4, 6–8) which is believed to be mainly fibroblastic (Fig. 1) and a phagocytic reticulum cell (9) or macrophage, which is known to be the center of erythropoietic islets (Fig. 2).
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References
Calvo W, Haas RJ: On the histiogenesis of the bone marrow in the rat: Innervation, stroma and their relations to hemopoiesis. Z Zellforsch Mikrosk Anat 1969, 95: 377–395.
Chen L-T, Weiss L: The development of vertebral bone marrow of human fetuses. Blood 1975, 46: 389–408.
Patt HM, Maloney MA: Bone marrow regeneration after local injury: A review. Exp Hematol (Oak Ridge) 1975, 3: 135–148.
Weiss L: The hematopoietic microenvironment of the bone marrow. An ultrastructural study of the stroma in rats. Anat Rec 1976, 186: 161–184.
Heyden von HW: Die ortsstandigen Knochenmarkzellen. In: Das Knochenmark, Queisser W, ed. Thieme-VIg Stuttgart 1978, 99–107.
Ito U: Electron microscopic study on benzene intoxicated rat bone marrow, with special reference to its reticuloendothelial structure. Bull Tokyo Med Dent Univ 1965, 12: 129.
Huhn D: Die Feinstruktur des Knochenmarks der Ratte bei Anwendung neurer Aldehydfixationen. Blut 1966, 13: 29 1304.
Tanaka Y, Goodman JR: Electron microscopy of human blood cells. Harper Row, Publishers, Inc., New York 1972, p. 348.
Policard A, Bessis M: Sur un mode d’incorporation des macromolecules par la cellule, visible au microscope electronique: la rhopheocytose. C R Acad Bulg Sci 1958, 246: 3194–2000.
Westen H, Bainton DF: Association of alkaline-phosphatase-reticulum cells (A1-RC) in bone marrow with granulocytic precursors. J Exp Med 1979, 150: 919–937.
Beckstead JH, Bainton DF: Enzyme histochemistry on bone marrow biopsies: Reactions useful in the differential diagnosis of leukemia and lymphoma applied to 2-micron plastic sections. Blood 1980, 55: 386–394.
Beckstead JH, Halverson P, Ries CA, Bainton DF: Enzyme histochemistry and immunohistochemistry on biopsy specimens of pathologic human bone marrow. Blood 1981, 57: 1088–1098.
Puchtler H, Waldrop FW: Silver impregnation methods for reticulum fibers and reticulin: A re-investigation of their origins and specificity. Histochemistry 1978, 57: 177–187.
Weiss L: The blood cells and hematopoietic tissues. Macnow A, Jeffers JD, Marshall DJ, eds. McGraw-Hill 1977, p. 487.
Bauermeister DE: Quantitation of bone marrow reticulin — a normal range. Am J Clin Path 1971, 56: 24–31.
Kleinman HK, Klebe RJ, Martin GR: Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 1981, 88: 473–485.
Linsenmayer TF: Collagen in cell biology of extracellular matrix. Hay ED, ed. Plenum Press, New York and London 1981, pp. 5–37.
Dexter TM: Stromal cell associated haemopoiesis. J Cellular Physiol Suppl 1982, 1: 87–94.
Hendrix MJC, Bainton DF, Hocking W, Hynes RO: Immunohistochemical localization of fibronectin (FN) in human bone marrow cultures. J Cell Biol 1981, 91: 165a.
Stern R, Bainton DF, Maloney MA, Patt HM: Stromal fibroblasts cultured from red bone marrow of young rabbits secrete predominantly type III procollagen (reticulum). Blood 1983, 62: suppl 1, 127a.
Friedenstein AJ, Latzinik NW, Grosheva AG, Gorskaya UF: Marrow microenvironment transfer by heterotopic transplantation of freshly isolated and cultured cells in porous sponges. Exp Hematol 1982, 10: 217–227.
Beckstead JH: The evaluation of human lymph nodes, using plastic sections and enzyme histochemistry. Am J Clin Pathol 1983, 80: 131–139.
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Bainton, D.F. (1985). Bone marrow stromal cells — fibroblasts and macrophages. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_13
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DOI: https://doi.org/10.1007/978-94-009-5020-7_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8723-0
Online ISBN: 978-94-009-5020-7
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