Abstract
Thalassemia is a genetically determined anemia prevalent in Mediteranean countries, the Middle East and South East Asia. It is an inherited disorder of the synthetic rate of globin chains resulting in unbalanced production of α- or (β-chains [1]. In Thailand both α- and (β-thalassemia are wide spread, and there is more than one subtype in each variety [2]. Besides, hemoglobin variants, i.e. HbE which is a (β-chain variant with lysine replacing glutamic acid at position 26 and Hb Constant Spring which is an α-chain mutant with 31 amino acid residues elongating from the C-terminal of the normal α-chain are also common [3, 4]. These abnormal genes in different combinations result in a spectrum of syndromes ranging from asymptomatic heterozygotes to lethal Hb Bart’s hydrop fetalis.
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References
Weatherall DJ, Clegg JB: The thalassemia symdrome. Oxford, Blackwell, 1972 (2nd edn).
Wasi P, Na-Nakorn S, Pootrakul S, Sookanek M, Disthasongchan P, Pornpatkul M, Panich V: Alpha- and Beta-thalassemia in Thailand. Ann NY Acad Sci 165: 60 - 82, 1969.
Wasi P: Haemoglobinopathies including thalassemia. Part 1: tropical Asia. Clin Haematol 10: 707 - 729, 1981.
Wasi P, Na-Nakorn S, Suingdumrong A: Studies of the distribution of haemoglobin E, thalassemias and glucose-6-phosphate dehydrogenase deficiency in north-eastern Thailand. Nature 214: 501 - 502, 1967.
Pootrakul P, Rugkiatsakul R, Wasi P: Increased transferrin iron saturation in splenectomized thalassemic patients. Brit J Haematol 46: 143 - 145, 1980.
Tanphaichitr VS, Suvatte V, Mahasanda C, Tuchinda S: Host defense in thalassemias and the effects of splenectomy I. Incidence of mild and severe infections. J Med Assoc Thailand 61: 66, 1978.
Johnston FE, Krogman WM: Patterns of growth in children with thalassemia major. Ann NY Acad Sci 119: 667 - 679, 1964.
Constantoulakis M. Panagopoulos G, Augoustaki O: Stature and longitudinal growth in thalassemia major. A study of 229 Greek patients. Clin Pediatr 14: 355 - 368, 1975.
Jelliffe DB: The assessment of nutritional status of the community. World Health Organization, Geneva, 1966.
Khanjansathiti P: The anthropometric nutritional classification in Thai infants and preschool children. J Med Assoc Thailand 60: 1-20 (suppl 1), 1977.
Chavalittamrong B, Vachakonon R: Height and weight of Bangkok children. J Med Assoc Thailand 61: 1-28 (suppl 2), 1978.
Johnston FE, Kieth P, Hertzog BA, Malina RM: Longitudinal growth in thalassemia major, Am J Dis Child 112: 396 - 401, 1966.
Tanphaichitr V, Kulapongse S: Diagnosis and management of adult protein-calorie malnutrition. In: Eng AS, Garcia-Webb P (eds) Clinical biochemistry, principles and practice. Singapore, Second Asian Pacific Congress of Clinical Biochemistry, 1983, pp 101 - 110.
Kattamis C, Touliatos N, Haidas S, Matsaniotis N: Growth of children with thalassemia: effect of different transfusion regimens. Arch Dis Child 45: 502 - 505, 1970.
Bhamarapravati N, Na-Nakorn S, Wasi P, Tuchinda S: Pathology of abnormal hemoglobin diseases seen in Thailand I. Pathology of (3-thalassemia hemoglobin E disease. Am J Clin Pathol 47: 745 - 757, 1967.
Mcintosh N: Endocrinopathy in thalassemia major. Arch Dis Child 51: 195 - 201, 1976.
Greulich WW, Pyle JS: Radiographic atlas of skeletal development of hand and wrist. Standford, Calif., Standford University Press, 1959.
Lodeweychx MV: The glucagon stimulation test: effect on plasma growth hormone, J Pediatr 85: 187 - 191, 1974.
Sonakul D, Sookanek M, Pacharee P: Pathology of thalassemia disease in Thailand. J Med Assoc Thailand 61: 72, 1978.
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Tanphaichitr, V.S., Tuchinda, C., Suvatte, V., Tuchinda, S. (1985). Bodily growth in thalassemia. In: Eeckels, R.E., Ransome-Kuti, O., Kroonenberg, C.C. (eds) Child Health in the Tropics. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5012-2_5
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DOI: https://doi.org/10.1007/978-94-009-5012-2_5
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