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Cardiovascular Effects of the Tranquilizers

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Animal Models in Cardiovascular Research

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Abstract

These agents are now more commonly classified as psychotropic or neuroleptic agents. This indicates a primary mode of action on certain functions of the central nervous system. Many of these agents have a profound effect on the cardiovascular system in addition to, or perhaps because of, their CNS activity. The CNS activity seems to be linked to the blockade of dopamine within the basal ganglia complex. The stereochemical model of chlorpromazine (one of the phenothiazine derivates) is similar to the structures of epinephrine, norepinephrine and dopamine but two–dimensional models of these compounds do not usually make the similarities apparent. Many of these compounds are apparently dopamine antagonists which act on dopamine excitatory receptors.1 The drugs are widely used for chemical restraint and preanesthetic agents when working with animals. The cardiovascular effects are summarized in Tables 3.1–3.9.

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  1. Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, 77843-4466, Texas, USA

    David R. Gross D.V.M., Ph.D.

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Gross, D.R. (1985). Cardiovascular Effects of the Tranquilizers. In: Animal Models in Cardiovascular Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5006-1_3

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  • DOI: https://doi.org/10.1007/978-94-009-5006-1_3

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