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Cardiovascular Effects of the Opiods

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Animal Models in Cardiovascular Research

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Abstract

The following compilation of opiods also includes some agents which are more correctly classified as narcotic antagonists. However, these agents usually compete for receptor sites and have some analgesic and/or sedative properties when used alone. The list is not exhaustive but represents those agents most commonly cited as being used for cardiovascular studies in the recent literature. The effectiveness of these agents for chemical restraint, sedation and analgesia seems to be a matter of individual preference more than objective evaluation, but also involves some species variability. The cardiovascular effects, dosage and appropriate comments are tabulated for each of the eleven agents in each of the species reviewed. In general, the opiodes are reported to decrease preload, contractility, after load and heart rate.1 If all of these responses are true, then the cardiac output must also decrease. Actual reported cardiovascular responses to the various opiods do not always follow this scheme, especially in cats and horses, where the narcotic analgesics have repeatedly been reported to cause a paradoxical excitement and stimulation.

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  1. Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, 77843-4466, Texas, USA

    David R. Gross D.V.M., Ph.D.

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Gross, D.R. (1985). Cardiovascular Effects of the Opiods. In: Animal Models in Cardiovascular Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5006-1_2

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  • DOI: https://doi.org/10.1007/978-94-009-5006-1_2

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