Abstract
Atherosclerosis is a pathological process which occurs, primarily, in large conduit arteries. There are focal accumulations of; cells within the intima of the artery, both intra- and extracellular lipids, fibrous tissue, complex proteoglycans, minerals, blood and blood products. As the disease progresses, necrosis often occurs, especially at the base of the lesion, along with damage to the media of the vessel, ulceration and eventual thrombosis.1 The disease is thought to occur when the influx and deposition of cholesterol into the wall exceeds the elimination from the wall, i.e. the process is continuous and dynamic. The cholesterol that is deposited seems to be derived from certain types of plasma lipoproteins. Other types of plasma lipoproteins may be able to remove the cholesterol from the arterial cells and transport it to the liver for elimination.2
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© 1985 Martinus Nijhoff Publishers Dordrecht
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Gross, D.R. (1985). Animal Models of Atherosclerosis. In: Animal Models in Cardiovascular Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5006-1_13
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DOI: https://doi.org/10.1007/978-94-009-5006-1_13
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