Abstract
Several concepts from basic cardiovascular physiology have and are being applied to clinical imaging. The purpose of this chapter is to review recent studies which addressed the relationship between regional myocardial blood flow and regional contractile function. The abbreviated term we have used to describe this subject is myocardial ‘flow-function relations’.
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References
Bugge-Asperheim, Leraand S, Kiil F: Local dimensional changes of the myocardium measured by ultrasonic technique. Scand J Clin Lab Invest 24: 361–371, 1969.
Gallagher KP, Osakada G, Hess OM, Koziol JA, Kemper WS, Ross J Jr: Subepicardial segmental function during coronary stenosis and the role of myocardial fiber orientation. Circ Res 50: 352–359, 1982.
Gallagher KP, Kumada T, Koziol JA, McKown MD, Kemper WS, Ross J Jr: Significance of regional wall thickening abnormalities relative to transmural myocardial perfusion in anesthe-tized dogs. Circulation 62: 1266–1274, 1980.
Gould KL, Kennedy JW, Frimer M, Pollack GH, Dodge HT: Analysis of wall dynamics and directional components of left ventricular contraction in man. Am J Cardiol 38: 322–331, 1976.
Sasayama S, Franklin D, Ross J Jr, Kemper WS, McKown D: Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog. Am J Cardiol 38: 870–879, 1976.
Goldstein S, de Jong JW: Changes in left ventricular wall dimensions during regional myocardial ischemia. Am J Cardiol 34: 56–62, 1974.
Kerber RE, Marcus ML, Ehrhardt J, Wilson R, Abboud FM: Correlation between echocar- diographically demonstrated segmental dyskinesis and regional myocardial perfusion. Circulation 52: 1097–1104, 1975.
Kerber RE, Marcus ML, Wilson R, Ehrhardt J, Abboud FM: Effects of acute coronary occlusion on the motion and perfusion of the normal and ischemic interventricular septum. An experimen-tal echocardiographic study. Circulation 54: 928–935, 1976.
Stowe DF, Mathey DG, Moores WY, Glantz SA, Townsend RM, Kabra P, Chatterjee K, Parmley WW, Tyberg JV: Segment stroke work and metabolism depend on coronary blood flow in the pig. Am J Physiol 234 (Heart Circ Physiol 3): H597–H607, 1978.
Vatner SF: Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ Res 47: 201–207, 1980.
Weintraub WS, Hattori S,Agarwal JB, Bodenheimer MM, Banka VS, Helfant RH: Relationship between myocardial blood flow and contraction by myocardial layer in the canine left ventricle. Circ Res 48: 430–438, 1981.
Gross GJ, Lamping KG, Warltier DC, Hardman HF: Effects of three bradycardic drugs on regional myocardial blood flow and function in areas distal to a total or partial coronary occlusion in dogs. Circulation 69: 391–399, 1984.
Tomoike H, Inou T, Watanabe K, Mizukami M, Kikuchi Y, Nakamura M: Functional significance of collaterals during ameroid-induced coronary stenosis in conscious dogs. Interrelationships among regional shortening, regional flow and grade of coronary stenosis. Circulation 67: 1001–1008, 1983.
Hill RC, Kleinman LH, Tiller WH Jr, Chitwood WR Jr, Rembert JC, Greenfield JC Jr, Wechsler AS: Myocardial blood flow and function during gradual coronary occlusion in awake dog. Am J Physiol 244 (Heart Circ Physiol 13): H60–H67, 1983.
Guth BD, White FC, Gallagher KP, Bloor CM: Abnormal wall thickening in myocardium adjacent to ischemic zones in conscious swine during brief coronary artery occlusion. Am Heart J 107: 458–464, 1984.
Heymann MA, Payne BD, Hoffman JIE, Rudolph AN: Blood flow measurements with radio-nuclide labeled particles. Prog Cardiovasc Dis 10: 55–79, 1977.
Gallagher KP, Matsuzaki M, Koziol JA, Kemper WS, Ross J Jr: Regional myocardial perfusion and wall thickening during ischemia in conscious dogs. Am J Physiol (in press).
Roan PG, Buja LM, Izquidedo C, Hashimi H, Saffer S, Willerson JT: Interrelationships between regional left ventricular function, coronary blood flow, and myocellular necrosis during the initial 24 hours and 1 week after experimental coronary occlusion in awake, unsedated dogs. Circ Res 49: 31–40, 1981.
Savage RM, Guth B, White FC, Hagan AD, Bloor CM: Correlation of regional myocardial blood flow and function with myocardial infarct size during myocardial ischemia in the conscious pig. Circulation 64: 699–707, 1981.
Gallagher KP, Matsuzaki M, Osakada G, Kemper WS, Ross J Jr: Effect of exercise on the relationship between myocardial blood flow and systolic wall thickening in dogs with acute coronary stenosis. Circ Res 52: 716–729, 1983.
Matsuzaki M, Gallagher KP, Patritti J, Tajimi T, Kemper WS, Ross J Jr: Effects of a calcium entry blocker (diltiazem) on regional myocardial flow and function during exercise in conscious dogs. Circulation 69: 801–814, 1984.
Ball RM, Bache RJ: Distribution of myocardial blood flow in the exercising dog with restricted coronary artery inflow. Circ Res 38: 60–66, 1976.
Sanders TM, White FC, Peterson TM, Bloor CM: Characteristics of coronary blood flow and transmural distribution in miniature pigs. Am J Physiol 235: H601–H609, 1978.
Tomoike H, Franklin D, McKown D, Kemper WS, Guberek M, Ross J Jr: Regional myocardial dysfunction and hemodynamic abnormalities during strenuous exercise in dogs with limited coronary inflow. Circ Res 42: 487–496, 1978.
Kumada T, Gallagher KP, Shirato K, McKown D, Miller M, Kemper WS, White F, Ross J Jr: Reduction of exercise induced regional myocardial dysfunction by propranolol: studies in a canine model of chronic coronary artery stenosis. Circ Res 46: 190–200, 1980.
Tomoike H, Franklin D, Kemper WS, McKown D, Ross J Jr: Functional evaluation of coronary collateral development in conscious dogs. Am J Physiol 241: H519–H524, 1981.
Arts T, Reneman RS, Veenstra PC: A model of the mechanics of the left ventricle. Ann Biomed Eng 7: 299–318, 1979.
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Gallagher, K.P. (1985). Physiologic concepts in cardiac imaging: Flow-function relations in acutely ischemic myocardium. In: Buda, A.J., Delp, E.J. (eds) Digital Cardiac Imaging. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4996-6_5
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DOI: https://doi.org/10.1007/978-94-009-4996-6_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8712-4
Online ISBN: 978-94-009-4996-6
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