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Positron emission computed tomography

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Digital Cardiac Imaging

Abstract

Regional myocardial blood flow and substrate metabolism can be non-invasively evaluated and quantified with positron emission computed tomography (Positron-CT). Tracers of exogenous glucose utilization and fatty acid metabolism are available and have been extensively tested. Specific tracer kinetic models have been developed or are being tested so that glucose and fatty acid metabolism can be measured quantitatively by Positron-CT [1, 2]. Tracers of amino acid and oxygen metabolism are utilized in Positron-CT studies of the brain [3] and development of such tracers for cardiac studies are in progress [4]. Methods to quantify regional myocardial blood flow are also being developed [5]. Previous studies have demonstrated the ability of Positron-CT to document myocardial infarction [6, 7]. Experimental and clinical studies have begun to identify metabolic markers of reversibly ischemic myocardium [8, 9]. The potential of Positron-CT to reliably detect potentially salvageable myocardium and, hence, to identify appropriate therapeutic interventions is one of the most exciting applications of the technique.

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Authors
  1. Maleah Grover
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  2. Heinrich R. Schelbert
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Editors and Affiliations

  1. Department of Internal Medicine, Cardiology Division, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Andrew J. Buda M.D.

  2. School of Electrical Engineering, Purdue University, West Lafayette, Indiana, USA

    Edward J. Delp Ph.D.

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© 1985 Martinus Nijhoff Publisher, Dordrecht

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Grover, M., Schelbert, H.R. (1985). Positron emission computed tomography. In: Buda, A.J., Delp, E.J. (eds) Digital Cardiac Imaging. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4996-6_14

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  • DOI: https://doi.org/10.1007/978-94-009-4996-6_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8712-4

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