Skip to main content

Neural control of coronary blood flow

  • Chapter
Simulation and Imaging of the Cardiac System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 43))

  • 73 Accesses

Abstract

Coronary physiology has recently been reviewed where a more extensive list of references may be found (Feigl, 1983).

The coronary vessels are innervated by both the parasympathetic and sympathetic divisions of the autonomic nervous system, as demonstrated by light microscope (Woollard, 1926) and electron microscope (Lever etal., 1965; Malor et al., 1973). Cholinergic innervation has been demonstrated with the acetyl- cholinesterase-staining technique (Denn and Stone, 1976; Gerova et al., 1979) and adrenergic innervation has been shown with flourescent histochemical methods (Denn and Stone 1976; Dolezel et al, 1978, Nielsen and Owman, 1968).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Berne RM, DeGeest H, Levy MN (1965) Influence of the cardiac nerves on coronary resistance. Am J Physiol 208: 763–769

    PubMed  CAS  Google Scholar 

  • Bhagat CI, Maharaj RR, Reid JVO (1976) Differential effect of right and left vagal stimulation on right and left circumflex coronary arteries. S Afr Med J 50: 1591–1594

    PubMed  CAS  Google Scholar 

  • Buffington CW, Feigl EO (1981) Adrenergic coronary vasoconstriction in the presence of coronary stenosis in the dog. Circ Res 48: 416–423

    PubMed  CAS  Google Scholar 

  • Buffington CW, Feigl EO (1983) Effect of coronary artery pressure on transmural distribution of adrenergic coronary vasoconstriction in the dog. Circ Res 53: 613–621

    PubMed  CAS  Google Scholar 

  • Dagget WM, Nugent GC, Carr PW, Powers PC, Harada Y (1967) Influence of vagal stimulation on ventricular contractility, O2 consumption, and coronary flow. Am J Physiol 212: 8–18

    Google Scholar 

  • Denn MJ, Stone HL (1976) Autonomic innervation of dog coronary arteries. J Appl Physiol 41: 30–35

    PubMed  CAS  Google Scholar 

  • Dolezel S, Gerova M, Gero J, Sladek T, Vasku J (1978) Adrenergic innervation of the coronary arteries and the myocardium. Acta Anat 100: 306–316

    Article  PubMed  CAS  Google Scholar 

  • Ehrhart IC, Parker PE, Weidner WJ, Dabney JM, Scott JB, Haddy FJ (1975) Coronary vascular and myocardial responses to carotid body stimulation in the dog. Am J Physiol 299: 754–760

    Google Scholar 

  • Feigl EO (1969) Parasympathetic control of coronary blood flow in dogs. Circ Res 25: 509–519

    PubMed  CAS  Google Scholar 

  • Feigl EO (1975a) Control of myocardial oxygen tension by sympathetic coronary vasoconstriction in the dog. Circ Res 37: 88–95

    PubMed  CAS  Google Scholar 

  • Feigl EO (1975b) Reflex parasympathetic coronary vasodilation elicited from cardiac receptors in the dog. Circ Res 37: 175–182

    PubMed  CAS  Google Scholar 

  • Feigl EO (1983) Coronary physiology. Physiol Rev 63: 1–205

    PubMed  CAS  Google Scholar 

  • Gerova M, Dolezel S, Gero J, Barta E (1979) Role of the vagus in control of the major conduit coronary artery in the dog. Physiol Bohemoslov 28: 299–307

    PubMed  CAS  Google Scholar 

  • Gwirtz PA, Stone HL (1981) Coronary blood flow and myocardial oxygen consumption after α-adrenergic blockade during submaximal exercise. J Pharmacol Exp Ther 217: 92–98

    PubMed  CAS  Google Scholar 

  • Hackett JG, Abboud FM, Mark AL, Schmid PG, Heistad DD (1972) Coronary vascular responses to stimulation of chemoreceptors and baroreceptors. Evidence for reflex activation of vagal cholinergic innervation. Circ Res 31: 8–17

    PubMed  CAS  Google Scholar 

  • Hashimoto K, Igarashi S, Uei I, Kumakura S (1964) Carotid chemoreceptor reflex effects on coronary flow and heart rate. Am J Physiol 206: 536–540

    PubMed  CAS  Google Scholar 

  • Heusch G, Deussen A (1983) The effects of cardiac sympathetic nerve stimulation on perfusion of stenotic coronary arteries in the dog. Circ Res 53: 8–15

    PubMed  CAS  Google Scholar 

  • Heyndrickx GR, Muylaert P, Pannier JL (1982) α-Adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs. Am J Physiol 242: H805–H809

    PubMed  CAS  Google Scholar 

  • Ito BR, Feigl EO (1984a) Carotid sinus baroreceptor reflex coronary vasodilation. In preparation

    Google Scholar 

  • Ito BR, Feigl EO (1984b) Carotid body chemoreceptor reflex parasympathetic coronary vasodilation. In preparation

    Google Scholar 

  • Johannsen UJ, Mark AL, Marcus ML (1982) Responsiveness to cardiac sympathetic nerve stimulation during maximal coronary dilation produced by adenosine. Circ Res 50: 510–517

    PubMed  CAS  Google Scholar 

  • Katz LN, Jochim K (1939) Observations on the innervation of the coronary vessels of the dog. Am J Physiol 126: 395–401

    Google Scholar 

  • Lever JD, Ahmed M, Irvine G (1965) Neuro-muscular and intercellular relationships in the coronary arterioles. A morphological and quantitative study by light and electron microscopy. J Anat 99: 829–840

    Google Scholar 

  • Malor R, Griffin CJ, Taylor S (1973) Innervation of the blood vessels in guinea-pig atria. Cardiovasc Res 7: 95–104

    Article  PubMed  CAS  Google Scholar 

  • Mohrman DE, Feigl EO (1978) Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation. Circ Res 42: 79–86

    PubMed  Google Scholar 

  • Mudge GH Jr, Grossman W, Mills RM Jr, Lesch M, Braunwald E (1976) Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N E J Med 295: 1333–1337

    Article  Google Scholar 

  • Mudge GH Jr, Goldberg S, Gunther S, Mann T, Grossman W (1979) Comparison of metabolic and vasoconstrictor stimuli on coronary vascular resistance in man. Circulation 59: 544–550

    PubMed  Google Scholar 

  • Murray PA, Vatner SF (1979) α-Adrenoceptor attenuation of the coronary vascular response to severe exercise in the conscious dog. Circ Res 45: 654–660

    PubMed  Google Scholar 

  • Nielsen KC, Owman C (1968) Difference in cardiac adrenergic innervation between hibernators and non-hibernating mammals. Acta Physiol Scan Suppl 316: 1–30

    Article  CAS  Google Scholar 

  • Religa Z, Trzebski A, Religa A, Glowienki A (1972) Effect of the stimulation of afferent fibers in Hering’s nerve on the blood flow and resistance in the coronary vessels of dogs. Pol Med J 11:632–641

    PubMed  CAS  Google Scholar 

  • Teidt N, Religa A (1979) Vagal control of coronary blood flow in dogs. Basic Res Cardiol 74: 267–276

    Article  Google Scholar 

  • Vatner SF, Franklin D, Van Citters RL, Braunwald E (1970) Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog. Circ Res 27: 11–21

    PubMed  CAS  Google Scholar 

  • Vatner SF, McRitchie RJ (1975) Interaction of the chemoreflex and the pulmonary inflation reflex in the regulation of coronary circulation in conscious dogs. Circ Res 37: 664–673

    PubMed  CAS  Google Scholar 

  • Woollard HH (1926) The innervation of the heart. J Anat Physiol 60: 345–373

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Feigl, E.O. (1985). Neural control of coronary blood flow. In: Sideman, S., Beyar, R. (eds) Simulation and Imaging of the Cardiac System. Developments in Cardiovascular Medicine, vol 43. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4992-8_24

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4992-8_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8710-0

  • Online ISBN: 978-94-009-4992-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics