Abstract
This paper examines the current flow patterns and excitation isochrones of a two-dimensional cardiac tissue with anisotropic intracellular and interstitial conductivity parameters. Only when the anisotrophy ratios in intracellular and interstitial space are equal does the behavior of current flow extrapolate from one dimensional cable theory. For realistic (measured) conductivities a component of action current flow is characterized by wide loops and multiple membrane crossings. Furthermore the transmembrane current at any site depend on transmembrane potential in the entire surrounding region. Isochrone simulation based on Hodgkin-Huxley rising phase shows that the assumption of local plane wave behavior is not generally acceptable. This is not surprising in view of the current flow patterns which do not correspond to simple one-dimensional flow, locally. The consequences of this study is that simulation of activation in real cardiac tissue must recognize the effects of anisotropy. The implications could be important not only for normal activation patterns but for studies of arrhythmias as well.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barr RC, Plonsey R (1984) Propagation of excitation in idealized anisotropic two-dimensional tissue. Biophys J 45: 831–850
Clerc L (1976) Directional differences of impulse spread in trabecular muscle from mammalian heart. J Physiol 255: 335–346
Hodgkin AL, Rushton WA (1946) The electrical constants of a crustacean nerve fiber. Proc Royal Soc 133: 444–479
Miller WT, Geselowitz DB (1978) Simulation studies of the electrocardiogram. Circ Res 43: 301–315
Muler AL, Markin VS (1978) Electrical properties of anistropic nerve-muscle syncytia. III. Steady form of the excitation front. Biophys 22: 699–704
Plonsey R, Barr RC (1984) Current flow patterns in two-dimensional anisotropic bisyncytia with normal and extreme conductivities. Biophys 45: 557–571
Roberts DL, Scher AM (1982) Effect of tissue anisotrophy on extra-cellular potential fields in canine myocardium in situ. Circ Res 50: 342–351
Roberts DL, Hersh LT, Scher AM (1979) Influence of cardiac fiber orientation on wavefront voltage, conduction velocity and tissue resistivity in the dog. Circ Res 44: 701–712
Schmitt O (1969) Biological information processing using the concept of interpenetrating domains. In: Leibovic KN (ed) Information Processing in the Nervous System, Springer-Verlag New York NY 325–331
Spach MS (1982) The electrical representation of cardiac muscle based on discontinuities of axial resistivity at a microscopic and macroscopic level. In: de Carvalho A Paes, Hoffman BE, Lieberman M (eds) Normal and Abnormal Conduction in the Heart, Mt. Kisco NY: Futura Publishing Co.
Spach MS, Kootsey JM (1983) The nature of electrical propagation in cardiac muscle. Amer J Physiol 244: H3–H22
Spach MS, Miller III WT, Miller-Jones E, Warren RB, Barr RC (1979) Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic cardiac muscle. Circ Res 45: 188–204
Tung L (1978) A bidomain model for describing ischemic myocardial DC potentials. Ph.D. dissertation Mass Inst Tech Cambridge MA
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Plonsey, R., Barr, R.C. (1985). Multidimensional activation of the heart: The effect of anisotropy in conductivity of cardiac tissue. In: Sideman, S., Beyar, R. (eds) Simulation and Imaging of the Cardiac System. Developments in Cardiovascular Medicine, vol 43. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4992-8_19
Download citation
DOI: https://doi.org/10.1007/978-94-009-4992-8_19
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8710-0
Online ISBN: 978-94-009-4992-8
eBook Packages: Springer Book Archive