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Bacterial Diarrheal Diseases pp 169–174Cite as

Secretory Immunity to Vibrio Cholerae Bacteria and Cholera Toxin: Prospects for an Improved Cholera Vaccine

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Part of the book series: New Perspectives in Clinical Microbiology ((NPCM,volume 9))

Abstract

While all age groups have been susceptible to cholera when it has spread into new areas, cholera is predominantly a disease of childhood in endemic areas. Studies in Bangladesh have shown a close inverse relationship between attack rate of cholera and age and also with serum (vibriocidal) antibody titers. This kind of epidemiologic pattern is characteristic of infections which evoke immunity following either disease or inapparent infection. There is also epidemiologic data from endemic areas which indicates that second attacks of cholera within a year or two are extremely rare (1, 2, R Glass et al., to be published).

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References

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Author information

Authors and Affiliations

  1. Department of Medical Microbiology, University of Göteborg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden

    A-M Svennerholm, M. Jertborn, L. Gothefors, A. Karim, D. Sack & J. Holmgren

  2. International Centre for Diarrhoeal Disease Research, G P O Box 128, Dhaka-2, Bangladesh

    A-M Svennerholm, M. Jertborn, L. Gothefors, A. Karim, D. Sack & J. Holmgren

Authors
  1. A-M Svennerholm
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  2. M. Jertborn
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  3. L. Gothefors
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  4. A. Karim
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  5. D. Sack
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  6. J. Holmgren
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Editor information

Editors and Affiliations

  1. The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Y. Takeda

  2. Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

    T. Miwatani

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© 1985 KTK Scientific Publishers, Tokyo

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Svennerholm, AM., Jertborn, M., Gothefors, L., Karim, A., Sack, D., Holmgren, J. (1985). Secretory Immunity to Vibrio Cholerae Bacteria and Cholera Toxin: Prospects for an Improved Cholera Vaccine. In: Takeda, Y., Miwatani, T. (eds) Bacterial Diarrheal Diseases. New Perspectives in Clinical Microbiology, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4990-4_17

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  • DOI: https://doi.org/10.1007/978-94-009-4990-4_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8709-4

  • Online ISBN: 978-94-009-4990-4

  • eBook Packages: Springer Book Archive

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