Abstract
In cases of plutonium contamination, performance of a microdosimetric evaluation is important from the radiation protection point of view because of the short range of the emitted alpha particles. This makes it necessary to obtain accurate data on the microdistribution of plutonium at various times after intake. Since plutonium is essentially a bone surface seeker, most of the data available in the literature refer to the plutonium microdistribution near endosteal and periosteal bone surfaces (1,2,3,4,5,6,7,8,9,10,11,12) considered the critical tissues for the induction of bone osteosarcomas. There is a paucity of data on plutonium microdistribution in adult cortical bone. The purpose of this study was to obtain data on plutonium microdistribution in cortical bone, which consists of a mineralized component and a soft tissue component, lining the forming and resorbing cavities and the Haversian and Volkmann’s canals. The soft tissue consists of various bone cells (13,14) considered to be at risk from radiation-induced osteosarcomas including bone lining cells and “osteoprogenitor” cells. Cortical bone is a dynamic structure subject to continuous remodeling: the removal of compact bone is followed by the replacement of a new Haversian system or osteon. Alpha irradiation of the remodeling units could promote pathological alterations in the skeleton (radiation osteodystrophy) as well as the induction of osteosarcomas (15,13,7,16).
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References
Arnold J.S. and Jee W.S.S. (1957). Bone growth and osteoclastic activity as indicated by radioautographic distribution of Pu239. Am. J. Anat., 101, 367–417.
Arnold J.S. and Jee W.S.S. (1962). Pattern of long term skeletal remodeling revealed by radioautographic distribution of 239Pu in dogs. Health Phys., 81, 705–707.
Twente J.A. and Jee W.S.S. (1961). Determination of Pu239 content of bone tissue: A comparison of radiochemical, track counting, and photoelectric density techniques. Health Phys., 59, 142–148.
Jee W.S.S., Arnold J.S., Cochran T.H, Twente J.A., and Mical R.S. (1962). Relationship of microdistribution of alpha particles to damage. In: Dougherty, T.F., Jee, W.S.S., Mays, C.W. and Stover, B.J. (eds.). Some Aspects of Internal Irradiation, pp. 27–45, ( Pergamon Press,. Oxford ).
Bleaney B. (1967). Radiation dose-rates near bone surfaces in rabbits after an injection of plutonium. Phys. Med. Biol., 12, 145–160.
Bleaney B. and Vaughan J. (1971). Distribution of 239Pu in the bone marrow and on the endosteal surface of the femur of adult rabbits following injection of 239Pu(NO3)4. Brit. J. Radiol., 44, 67–73.
Vaughan J. (1973). Distribution, excretion and effects of plutonium as a bone seeker. In: Hodge, H.C., Stannard, J.N. and Hursh, J.B. (eds.) Handbook of Experimental Pharmacology, Vol. 36: Uranium, Plutonium, Transplutonic Elements, pp. 349–502 ( Springer-Verlag, Berlin ).
Schlenker R.A., Oltman B.G. and Cummins H.T. (1976). Microscopic distribution of 239Pu deposited in bone from a human injection case. In: Jee, W.S.S. (ed.). The Health Effects of Plutonium and Radium. pp. 321–328 ( J.W. Press, Salt Lake City ).
Wronski T.J., Smith J.M., and Jee W.S.S. (1980). The microdistribution and retention of injected 239Pu on trabecular bone surfaces of the beagle: implications for the induction of ostosarcomas. Radiat.Res., 83, 74–89
Priest N.D. and Giannola S.J. (1980). 241Pu deposition and redistribution in the rat rib. Int. J. Radiat. Biol., 37, 281–298.
Green D., Howells G.R. and Thorne M.C. (1978). Plutonium-239 deposition in the skeleton of the mouse. Int. J. Radiat. Biol., 34, 27–36.
Green D, Howells G.R. and Thorne M.C. (1981). A semiautomated technique for assessing the microdistribution of 239Pu deposited in bone. Phys. Med. Biol., 26: 379–387.
Loutit J.F., Brues A.M., Marinelli L., Spiers F.W. and Vaughan J. (1968). A Review of the Radiosensitivity of the Tissues in Bone, ICRP Publication 11 ( Pergamon Press, Oxford ).
Jee W.S.S. (1983). The skeletal tissues. In: Weiss, L. (ed.). Histology, pp. 200–255, ( Elsevier Biomedical, New York.
Jee W.S.S. (1962). Histopathological endpoints in compact bone receiving alpha emitters. In: Dougherty, T.F., Jee, W.S.S., Mays, C.W. and Stover, B.J. (eds.). Some Aspects of Internal Irradiation, pp. 95–113 ( Pergamon Press, Oxford ).
Pool R.R., Morgan J.P., Parks N.J., Farnham J.E. and Littman M.S. (1983). Comparative pathogenesis of radium-induced intracortical bone lesions in human and beagles. Health Phys., 44 155–177, Suppl. No. 1.
Jee W.S.S., Dell R.B. and Miller L.G. (1972). High resolution neutron-induced autoradiography of bone containing 239Pu. Health Phys., 22, 761–763.
Fellows M.H., Clark L., O’Toole J.J., Kimmel D.B. and Jee W.S.S. (1975). An improved technique for neutron-induced autoradiography of bone containing plutonium. Health Phys., 29, 97–101.
Woodbury L.A., Woodbury N.A., Wronski T. and Jee W.S.S. (1976). In: Jee, W.S.S. (ed.). Preliminary studies on the use of the Quantimet-720 for the measurement of radiographs of bone sections, Research in Radiobiology. pp. 285–304 (COO-119-251, Division of Radiobiology, University of Utah, Salt Lake City.
Elias H and Hyde D.M. (1980). An elementary introduction to stereology (Quantitative microscopy). Am. J. Anat., 159, 12–446.
Humphreys E.R, Green D, Howells G.R. and Thorne M.C. (1982). Relationship between blood flow, bone strucure, and 239Pu deposition in the mouse skeleton. Calcif. Tissue Int., 34, 416–421.
Jee W.S.S. and Arnold J.S. (1960). Effects of internally deposited radioisotopes upon blood vessels of cortical bone. Proc. Soc. Exptl. Biol. & Med., 105, 351–156.
Jee W.S.S. (1964). The influence of reduced local vascularity on the rate of internal reconstruction of adult long bone cortex. In: Frost, H.M. (ed.). Bone Biodynamics, pp. 259–277, ( Little Brown, Boston ).
Stover B.J. and Atherton D.R. (1974). Kinetics of the skeletal retention of 239Pu (IV). Radiat. Res., 60, 525–535.
Bruenger F. (1983). Personal communication. Radiobiology Division, Department of Pharmacology, Univ. of Utah.
Thorne M.C. (1976). Aspects of the dosimetry of plutonium in bone. Nature, 259, 539–541.
Beddoe A.H. (1977). Measurements of the microscopic structure of cortical bone. Phys. Med. Biol., 22, 298–308.
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Ingrao, G., Jee, W.S.S. (1985). Pu Microdistribution Study in Cortical Bones of Beagle Dogs. In: Priest, N.D. (eds) Metals in Bone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4920-1_18
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DOI: https://doi.org/10.1007/978-94-009-4920-1_18
Publisher Name: Springer, Dordrecht
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