Abstract
The effects of stable strontium (Sr) on bone and mineral metabolism have been studied for many years.However, most investigations were concerned with high dosage levels of Sr and the influence of low doses of Sr on bone are yet to be determined. It is known that high doses of Sr diminish the intestinal absorption of calcium (Ca) and inhibit the renal conversion of 25 hydroxyvitamin D (25-OH D) to 1,25 dihydroxyvitamin D (1,25 (OH) 2 D (Co 70, Om 72). Dietary Sr supplementation at the dose of 1.5 % in the rat induces hypocalcemia (St 62) as well as defective bone mineralization which occurs in spite of adequate amounts of Ca in the diet (St 62). By contrast, low doses of Sr do not seem to generate detectable abnormalities in mineral and bone metabolism in the rat despite significant elevation of Sr levels in serum (Sk 81). Interestingly, Sr supplementation at low dosage was reported to increase bone calcification in osteoporotic patients (Sh 52, Ja 59) but it is not known whether this beneficial effect resulted from decreased bone resorption and/ or increased bone formation. This study was therefore undertaken to evaluate the effects of low doses of stable Sr on mineral homeostasis, vitamin D metabolism and bone histology in the rat.
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Marie, P.J., Garba, MT., Hott, M., Miravet, L. (1985). Effect of Stable Strontium on Bone Metabolism in Rats. In: Priest, N.D. (eds) Metals in Bone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4920-1_12
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DOI: https://doi.org/10.1007/978-94-009-4920-1_12
Publisher Name: Springer, Dordrecht
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