Skip to main content

Long-Term Retention and Turnover Studies with 85Sr

  • Chapter
Metals in Bone
  • 64 Accesses

Abstract

Over the last thirty years there has been considerable interest in the study of the metabolism of the radioisotopes of strontium in man. This has been stimulated by three main factors. Firstly, the need arose to quantitate the dangers arising from the contamination of the environment and of workers in the nuclear industry, by 90Sr and other boner-seeking radionuclides. Secondly, it was recognised that 85Sr might be a useful tracer for bone calcium; and finally, before the development of 99Tcm based agents, 87Srm was widely used for bone scanning purposes in clinical nuclear medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arlot M., Edouard C., Meunier P. J.. Neer R. M. and Reeve J., 1984, “Impaired Osteoblast Function in Osteoporosis: Comparison between: Calcium Balance and Dynamic Histomorphometry”, Br. Med. J. 289, 517–520.

    Article  CAS  Google Scholar 

  2. Bullamore J. R., Nordin B. E. C., Wilkinson R. and Marshall D. H., 1971, “Radiocaicium Measurements of Bone Turnover in Disorders of Calcium Metabolism using a Model Based on an Expanding Pool”, In: Dynamic Studies with Radioisotopes in Medicine (Proc. Symp., Rotterdam 1970). pp. 519–538 ( Vienna: IAEA ).

    Google Scholar 

  3. Carr T. E. F., Harrison G. E. and Nolan J., 1973, “The Long-term Excretion and Retention of an Intravenous Dose of 45Ca in Two Healthy Men”, Calcif. Tiss. Res. 12, 217–226.

    Article  CAS  Google Scholar 

  4. Charles P., Jensen F. T., Mosekilde L. and Hansen H. H., 1983. “Calcium Metabolism Evaluated by 47Ca Kinetics: Estimation of Dermal Calcium Loss”, Clin. Sci. 65, 415–422.

    PubMed  CAS  Google Scholar 

  5. Gallagher J. C., Riggs B. L., Eisman J., Hamstra A., Arnaud S. B. and De Luca H. F., 1979, “Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic Patients”, J. Clin. Invest. 64, 729–736.

    Article  PubMed  CAS  Google Scholar 

  6. Heaney R. P., Becker R. R. and Saville P. D., 1978. “Menopausal Changes in Bone Remodeling”, J. Lab. Clin, Med, 92. 964–970.

    CAS  Google Scholar 

  7. Jung A., Bartholdi P., Mermillod B., Reeve J. and Neer R. M., 1978, “Critical Analysis of Methods for Analysing Human Calcium Kinetics”, J. Theoret. Biol, 73, 131–157.

    Article  CAS  Google Scholar 

  8. Lauffenburger T., Olah A. J., Dambacher M. A., Guncaga J.. Lentner C. and Haas H. G., 1977, “Bone Remodelling and Calcium Metabolism: A Correlated Histomorphometric, Calcium Kinetic, and Biochemical Study in Patients with Osteoporosis and Paget’s Disease”; Metabolism 26, 589–606.

    Article  PubMed  CAS  Google Scholar 

  9. Marshall J. H., 1969, “Measurements and Models of Skeletal Metabolism”, In: Mineral Metabolism, vol. 3 (Edited by C. L. Comar and F. Bronner ), pp. 1–122 ( New York: Academic Press ).

    Google Scholar 

  10. Marshall J. H., Lloyd E. L., Rundo J., Liniecki J., Marotti G., Mays C. W., Sissons H. A. and Snyder W. S., 1973, “Alkaline Earth Metabolism in Adult Man” (ICRP Publication 20), Health Phys. 24, 125–221.

    Article  Google Scholar 

  11. Meunier P. J., 1983, “Histomorphometry of the Skeleton”, In: Bone and Mineral Research Annual I (Edited by W. A. Peck ), pp. 191–222 ( Amsterdam: Excerpta Medica. )

    Google Scholar 

  12. Pearson O. H. and Joplin G. F. (Editors). 1964, Dynamic Studies of Metabolic Bone Disease ( Oxford: Blackwell ).

    Google Scholar 

  13. Reeve J.. Hesp R. and Wootton R., 1976. “A New Tracer Method for the Calculation of Rates of Bone Formation and Breakdown in Osteoporosis and Other Generalised Skeletal Disorders”. Calcif, Tiss. Res. 22, 191–206.

    Article  CAS  Google Scholar 

  14. Reeve J. and Hesp R.. 1976, “A Model-independent Comparison of the Rates of Uptake and Short Term Retention of 47Ca and 85Sr by the Skeleton”. Calcif. Tiss. Res. 22. 183–189.

    Article  CAS  Google Scholar 

  15. Reeve J., 1978: “The Turnover Time of Calcium in the Exchangeable Pools of Bone in Man and the Long-term Effect of a Parathyroid Hormone Fragment”, Clin, Endocrinol. 8 445–455.

    Article  CAS  Google Scholar 

  16. Reeve J., Arlot M.. Bernat M., Charhon S., Edouard C., Slovik D., Vismans F.J.F.E. and Meunier P. J., 1981. “Calcium-47 Kinetic Measurements of Bone Turnover Compared to Bone Histomorphometry in Osteoporosis: the Influence of Human Parathyroid Fragment (hPTH 1–34) Therapy”. Metab. Bone Dis. Rel. Res. 3. 23–30.

    Article  CAS  Google Scholar 

  17. Reeve J., Green J. R., Hesp R. and Hulme P., 1982, “Rates of New Bone Formation in Patients with Crush Fracture Osteoporosis”. Clin. Sci. 63, 153–160.

    PubMed  CAS  Google Scholar 

  18. Reeve J., Green J. R., Maletskos C. J. and Neer R. M., 1983, “Skeletal Retention of 45Ca and 85Sr Compared: Further Studies on Intravenously Injected 85Sr as a Tracer for Skeletal Calcium”. Calcif Tiss. Int. 35, 9–15.

    Article  CAS  Google Scholar 

  19. Reeve J., Arlot M., Hesp, R., Tellez M. and Meunier P. J., 1983. “Tracer Measurements of Bone Remodeling and their Significance in Involutional Osteoporosis”. In Clinical Disorders of Bone and Mineral, Metabolism (Edited by B. Frame and J. T. Potts, Jr), pp. 99–104 (Amsterdam: Excerpta Medica).

    Google Scholar 

  20. Rowland R. E., 1966, “Exchangeable Bone Calcium”, Clin. Orthop, Rel. Res. 49. 233–248.

    CAS  Google Scholar 

  21. Wootton R., Tellez M., Green J. R. and Reeve J., 1981. “Skeletal Blood Flow In Paget’s Disease of Bone”. Metab. Bone Dis. Rel. Res. 4 5, 263–270.

    Article  Google Scholar 

Download references

Authors

Editor information

Nicholas D. Priest

Rights and permissions

Reprints and permissions

Copyright information

© 1985 ECSC, EEC, EAEC, Brussels and Luxembourg

About this chapter

Cite this chapter

Sambrook, P.N., Hesp, R., Green, J.R., Tellez, M., Meunier, P.J., Reeve, J. (1985). Long-Term Retention and Turnover Studies with 85Sr. In: Priest, N.D. (eds) Metals in Bone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4920-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4920-1_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8680-6

  • Online ISBN: 978-94-009-4920-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics