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Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle

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Future Aspects in Contraception

Abstract

In 1928 Corner and Allen wrote: ‘We have been able to prepare alcoholic extracts of the corpora lutea of swine which produce in spayed rabbits a condition of the uterus identical with normal progestational proliferation’1.

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References

  1. Corner, G. and Allen, W. (1928). Quoted in Aiman, J. (ed.) (1984). Infertility. Diagnosis and Management, p. 14. ( New York: Springer-Verlag )

    Google Scholar 

  2. Philibert, D., Deraedt, R. and Teutsch, G. (1981). RU 38486 a potent antiglucocorticoid in vivo. In Eighth International Congress of Pharmacology. Vol. 668, 1463 (Abstract). ( Tokyo: Japanese Pharmacological Society and Science Council of Japan )

    Google Scholar 

  3. Healy, D. L., Baulieu, E. E. and Hodgen, G. D. (1983). Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects. Fertil. Stern., 40, 253

    CAS  Google Scholar 

  4. Institut Roussel UCLAF, Paris. Internal report

    Google Scholar 

  5. Hodgen, G. D. (1982). The dominant ovarian follicle. Fertil. Stern., 38, 281

    CAS  Google Scholar 

  6. Schindler, A. M., Zanon, P., Obradovic, D., Wyss, R., Graff, P. and Herrmann, W. L. (1984). Interruption of early pregnancy with RU 496. A morphological study. Am, J. Obstet. Gynecol. (In press)

    Google Scholar 

  7. March, C. M., Goebelsmann, U., Nakamura, R. M. and Mishell, D. R. (1979). Roles of estradiol and progesterone in eliciting the midcycle luteinizing hormone and folliclestimulating hormone surges. J. Clin. Endocrinol. Metab., 49, 507

    Article  PubMed  CAS  Google Scholar 

  8. March, C. M., Marrs, R. P., Goebelsmann, R. and Mishell, D. R. (1981). Feedback effects of estradiol and progesterone upon gonadotrophin and prolactin release. Obstet. Gynecol., 58, 10

    PubMed  CAS  Google Scholar 

  9. Fritz, M. A. and Speroff, L. (1982). The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil. Steril., 38, 509

    PubMed  CAS  Google Scholar 

  10. Kovacs, L., Sas, M., Resch, B.A., Ugocsai, G., Swahn, M.L., Bygdeman, M. and Rowe, P. J. (1984). Termination of very early pregnancy by RU 486—an antiprogestational compound. Contraception, 29, 399

    Article  PubMed  CAS  Google Scholar 

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Authors

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B. Runnebaum T. Rabe L. Kiesel

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© 1985 MTP Press Limited

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Herrmann, W.L., Schindler, A.M., Wyss, R., Bischof, P. (1985). Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle. In: Runnebaum, B., Rabe, T., Kiesel, L. (eds) Future Aspects in Contraception. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4916-4_22

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  • DOI: https://doi.org/10.1007/978-94-009-4916-4_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8678-3

  • Online ISBN: 978-94-009-4916-4

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