Abstract
The principal objectives of the formulator of topical medicinal products are to design a dosage form which is both chemically and physically stable and is cosmetically acceptable. In addition, there is the need to ensure that the vehicle provides optimal delivery of the drug to the target tissues. Effective therapy will only be achieved if the various interactions and actions resulting post-application of the dosage form to the skin surface occur in a controlled manner. Drug release, penetration and target activity are dependent on the interactions occurring between drug, vehicle and skin. Vehicle-drug interactions will determine the drug release profile, whilst vehicle-skin interactions can modulate the penetration phase.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Higuchi, T. (1960). Physical chemical analysis of percutaneous absorption process from creams and ointments. J. Soc. Cosmet. Chem., 11, 85–97
Scheuplein, R.J. (1965). Mechanism of percutaneous absorption. 1. Routes of penetration and influence of solubility. J. Invest. Dermatol., 45, 334–346
Katz, M. and Poulsen, B.J. (1972). Corticoid, vehicle and skin interaction in percutaneous absorption. J. Soc. Cosmet. Chem., 23, 565–590
Shelmire, J.B. (1960). Factors determining the skin-drug-vehicle relationship. Arch. Dermatol., 82, 24–31
Bettley, F.R. (1965). Influence of detergents and surfactants on epidermal permeability. Br. J. Dermatol., 77, 98–100
Bettley, F.R. (1961). Influence of soap on the permeability of the epidermis. Br. J. Dermatol., 73, 448–454
Bettley, F.R. (1963). Irritant effect of soap in relation to epidermal permeability. Br. J. Dermatol., 75, 113–116
Scheuplein, R. J. and Ross, L. (1970). Effects of surfactants and solvents on the permeability of epidermis. J. Soc. Cosmet. Chem., 21, 853–873
Wepierre, J. and Marty, J. P. (1977). Rôle des excipients et des agents tensio- actifs dans l’absorption percutanée des substances chimiques. Gattefossé Report, pp. 53–59
Mezei, M. and Gulasekharam, V. (1980). Liposomes - a selective drug delivery system for the topical route of administration. Life Sci., 26, 1473–1477
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 MTP Press Limited
About this chapter
Cite this chapter
Kellaway, I.W. (1985). The Influence of Formulation on Percutaneous Absorption. In: Marks, R. (eds) Topics in Topicals. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4906-5_12
Download citation
DOI: https://doi.org/10.1007/978-94-009-4906-5_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8673-8
Online ISBN: 978-94-009-4906-5
eBook Packages: Springer Book Archive