Abstract
To consider trends in hepatology and to risk a look into the future of science is a dangerous task. Futurology backed by dubious authority has been known to inhibit rather than to foster scientific progress. However, we meet here to pay homage to a colleague who very early recognized a trend among hepa-tologists from differing disciplines — the desire to meet every year and exchange knowledge and ideas — and who was extremely successful in firmly establishing this trend. Thus, it may be appropriate to look at recent developments and to try to foresee future trends.
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References
Jungermann, K. and Sasse, D. (1978). Heterogeneity of liver parenchymal cells. Trends Biochem. Sci, 3, 198–202
Sasse, D., Katz, N. and Jungermann, K. (1975). Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes. FEBS Lett, 57, 83–8
Haussinger, D., Gerok, W. and Sies, H. (1984). Hepatic role in pH regulation: role of the intercellular glutamine cycle. Trends Biochem. Sci, 9, 300–2
Jungermann, K. and Katz, N. (1982). Functional hepatocellular heterogeneity. Hepatology, 2, 385–95
Decker, K. and Kreusch, J. (1982). 9th International RES Congress, Davos. See also Kreusch, J., Thesis, Medical Faculty, The University of Freiburg ( FRG ) 1979. Binding, uptake and degradation of peptide hormones by macrophages.
Nagelkerke, J. F., Barto, K. P. and van Berkel, T. J. C. (1983). In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer and parenchymal cells. J. Biol. Chem, 258, 12221–7
Henriksen, T., Mahoney, E. M. and Steinberg, D. (1981). Enhanced macrophage degra-dation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoprotein. Proc. Natl. Acad. Sci. USA, 78, 6499–503
Goldstein, J. L., Basu, S. K. and Brown, M. S. (1983). Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Meth. Enzymol, 98, 241–60
Blomhoff, R., Holte, K., Naess, L. and Berg, T. (1984). Newly administered ∣3H∣retinol is transferred from hepatocytes to stellate cells in liver for storage. Exp. Cell Res, 150, 186–93
Blouin, A., Bolender, R. P. and Weibel, E. R. (1977). Distribution of organelles and membranes between hepatocytes and non hepatocytes in the rat liver parenchyma. A stereological study. J. Cell. Biol, 72, 441–55
Dileepan, K. N., Wagle, S. R., Hofmann, F. and Decker, K. (1979). Distribution profile of glucokinase and hexokinase in parenchymal and sinusoidal cells of rat liver during development. Life Sci, 24, 89–96
Knook, D. L., Sleyster, E. C. and Teutsch, H. F. (1980). High activity of glucoses- phosphate dehydrogenase in Kupffer cells isolated from rat liver. Histochemistry, 69, 211–16
Teutsch, H. F. (1981). Chemomorphology of liver parenchyma. Qualitative histochemical distribution patterns and quantitative sinusoidal profiles of G-6-Pase, G-6-PDH and malic enzyme activity and of glycogen content. Progr. Histochem. Cytochem, 14, 1–92
Bhatnagar, R., Schirmer, R., Ernst, M. and Decker, K. (1981). Superoxide release by zymosan-stimulated rat Kupffer cells in vitro. Eur. J. Biochem, 119, 171–5
Rieder, H., Birmelin, M. and Decker, K. (1982). Synthesis and functions of fibronectin in rat liver cells in vitro. In Knook, D. L. and Wisse, E. (eds.) Sinusoidal Liver Cells, pp. 193–200. ( Amsterdam, New York, Oxford: Elsevier Biomedical Press )
Birmelin, M. and Decker, K. (1984). Synthesis of prostanoids and cyclic nucleotides by phagocytosing rat Kupffer cells. Eur. J. Biochem, 142, 219–25
Bhatnagar, R., Schade, U., Rietschel, Th.E. and Decker, K. (1982). Involvement of prostaglandin E and cyclic adenosin 3’,5’-monophosphate in lipopolysaccharide- stimulated collagenase release by rat Kupffer cells. Eur. J. Biochem, 125, 125–30
Birmelin, M. and Decker, K. (1983). Ca2+ flux as an initial event in phagocytosis by rat Kupffer cells. Eur. J. Biochem, 131, 539–43
Perez, H. D., Roll, F. J., Bissell, D. ML, Shak, S. and Goldstein, I. M. (1984). Production of chemotactic activity for polymorphonuclear leukocytes by cultured rat hepatocytes exposed to ethanol. J. Clin. Invest, 74, 1350–57
Bauer, J., Birmelin, M., Northoff, G.-H., Northemann, W., Tran-Thi, T. A., Ueberberg, H., Decker, K. and Heinrich, P. (1984). Induction of rat α2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell-derived factor. FEBS Lett, 177, 89–94
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Decker, K. (1985). Synthetic hepatology. In: Bianchi, L., Gerok, W., Popper, H. (eds) Trends in Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4904-1_9
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DOI: https://doi.org/10.1007/978-94-009-4904-1_9
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