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Epstein-Barr virus in chronic hepatitis

  • Chapter
Trends in Hepatology

Abstract

Involvement of the liver in Pfeiffer’s ‘glandular fever’1 was recognized soon after the term ‘infectious mononucleosis’ was coined in 19202. Jaundice was noted in isolated patients in the 1920s3,4. During and after World War II, with the advent of liver biopsy and heterophile antibody testing, details of the epidemiology, transmission of the disease and the involvement of the liver were uncovered. Anicteric5 and even subclinical cases of hepatitis were described, some in epidemics6. The hepatic abnormalities were long lasting in about 10% or more of cases6,7, and even one case of cirrhosis was reported8. Histologically, the portal tracts and sinusoids were the sites of lymphocytic infiltration9,10, the extent of lymphocytosis correlating with abnormal results of various hepatic tests10. After Henle, et al.11 related the virus found in Burkitt’s lymphoma, by Epstein et al.12, to infectious mononucleosis, immunologic tests were rapidly developed to define the status of Epstein- Barr virus (EBV) infection13. EBV as well as the other human herpes viruses can be easily recognized by electron microscopy, but they cannot be distinguished from one another by appearance alone14. EBV can readily be transmitted by transfusions15–17, haemodialysis18 and intimate or sexual contact including male homosexual contact19.

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Authors
  1. F. Schaffner
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Editors and Affiliations

  1. Department of Pathology, University of Basel, Schöbeinstrasse 40, CH-4056, Basel, Switzerland

    L. Bianchi

  2. University Medical Clinic, University of Freiburg, West Germany

    W. Gerok

  3. Mount Sinai School of Medicine of the City, University of New York, USA

    H. Popper

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© 1985 MTP Press Limited

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Schaffner, F. (1985). Epstein-Barr virus in chronic hepatitis. In: Bianchi, L., Gerok, W., Popper, H. (eds) Trends in Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4904-1_23

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  • DOI: https://doi.org/10.1007/978-94-009-4904-1_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8672-1

  • Online ISBN: 978-94-009-4904-1

  • eBook Packages: Springer Book Archive

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