Abstract
Although the incidence of sexually transmitted diseases (STDs) has increased in many countries, our knowledge about the immunobiology of the etiologic agents is inadequate to develop effective vaccines and minimize the incidence of these infections. Because most of the etiologic agents of STDs are pathogenic only for humans, experimental infectivity studies are limited. Why these organisms infect only humans and not other vertebrates is not known, but it is possible to speculate on the microbial factors that are involved.
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References
Andresen, R. H. and Monroe, C. W. (1962). Experimental study of the behavior of adult human skin homografts during pregnancy. A preliminary report. Am. J. Obstet. Gynecol., 84, 1096
Arko, R. J. (1972). Neisseria gonorrhoeae: experimental infection of laboratory animals. Science, 177, 1200
Arko, R. J., Kraus, S. T., Brown, W. J. et al. (1974). Neisseria gonorrhoeae: effect of systemic immunization on resistance of chimpanzees to urethral infection. J. Infect. Dis., 130, 160
Arko, R. J., Wong, K. H., Bullard, J. C. et al. (1976). Immunological and serological diversity of Neisseria gonorrhoeae: immunotyping of gonococci by cross-protection in guinea pig subcutaneous chambers. Infect. Immun., 14, 1293
Baker, D. A. and Plotkin, S. A. (1978). Enhancement of vaginal infection in mice by Herpes Simplex Virus Type II with progesterone (40156). Proc. Soc. Exp. Biol. Med., 158, 131
Bang, F. (1941). Experimental gonococcus infection of the chicken embryo. J. Exp. Med., 74, 387
Braude, A. I., Corbeil, L. B., Levine, S. et al. (1978). Possible influence of cyclic menstrual changes on resistance to the gonococcus. In Brooks, G. F., Gotschlich, E. C. and Holmes, K. K. et al. (eds) Immunobiology of Neisseria gonorrhoea, p. 328 ( Washington, DC: Am. Soc. Microbiol. )
Brown, W. J., Lucas, C. T. and Kuhn, U. S. G. (1972). Gonorrhea in the chimpanzee. Infection with laboratory-passed gonococci and by natural transmission. Br. J. Vener. Dis., 48, 177
Buchanan, T. M. and Gotschlich, E. C. (1973). Studies on gonococcus infection. III. Correlation of gonococcal colony morphology with infectivity for the chick embryo. J. Exp. Med., 137, 196
Bumgarner, L. R. and Finkelstein, R. A. (1973). Pathogenesis and immunology of experimental gonococcal infection: virulence of colony types of Neisseria gonorrhoeae for chicken embryos. Infect. Immun., 8, 919
Catterall, R. D. (1971). Influence of gestogenic contraceptive pills on vaginal candidasis. Br. J. Vener. Dis., 47, 45
Diena, B. B., Ryan, A., Ashton, F. E. et al. (1975). A mouse intracerebral infection with Neisseria gonorrhoeae. Br. J. Vener. Dis., 51, 22
Farber, P. A. and Glasgow, L. A. (1968). Factors modifying host resistance to virus infection. II. Enhanced susceptibility of mice to encephalomyocarditis virus infection during pregnancy. Am. J. Pathol., 53, 463
Fierer, J., Talner, L. and Brande, A. I. (1971). Bacteremia in the pathogenesis of retrograde E. coli pyelonephritis in the rat. Am. J. Pathol., 64, 443
Hill, J. H. and Pitts, A. C. (1939). The growth of Neisseria gonorrhoeae on the chorioallantoic membrane of the chick embryo. J. Urol., 41, 81
Karthigasu, K. and Jenkin, C. R. (1963). The functional development of the reticuloendothelial system of the chick embryo. Immunology, 6, 255
Keefer, C. S. and Spink, W. W. (1938). Studies of gonococcal infection. IV. The effect of mucin on the bacteriolytic powder of whole blood and immune serum. J. Clin. Invest., 17, 23
Kellogg, D. S., Jr., Cohen, I. R., Norins, L. C. et al. (1968). Neisseria gonorrhoeae. II.Colonial variation and pathogenicity during 35 months in vitro. J. Bacteriol., 96, 596
Kellogg, D. S., Jr., Peacock, W. L., Jr., Deacon, W. E. et al. (1963). Neisseria gonorrhoeae. I. Virulence genetically linked to colonial variation. J. Bacteriol., 85, 1274
Kent, R. (1961). The development of the phagocytic activity of the reticulo-endothelial system in the chick. J. Embryol. Exp. Morphol., 9, 128
Kita, E., Matsuura, H. and Kashiba, S. (1981). A mouse model for the study of gonococcal genital infection. J. Infect. Dis., 143, 67
Larsen, B., Markovetz, A. J. and Galask, R. P. (1977). Relationship of vaginal cytology to alterations of the vaginal microflora of rats during the estrous cycle. Appl. Environ. Microbiol., 33, 556
Lucas, C. T., Chandler, F., Jr., Martin, J. E., Jr. et al. (1971). Transfer of gonococcal urethritis from man to chimpanzee. An animal model for gonorrhea. J. Am. Med. Assoc., 216, 1612
Metzger, M. and Smogor, W. (1969). Artificial immunization of rabbits against syphilis. I. Effect of increasing doses of treponemes given by the intramuscular routes. Br. J. Vener. Dis., 45, 308
Miller, J. N. (1965). Immunity in experimental syphilis. J. Bacteriol., 90, 297
Miller, J. N. (1967). Immunity in experimental syphilis. V. The immunogenicity of Treponema pallidum attenuated by γ-irradiation. J. Immunol., 99, 1012
Miller, J. N. (1973). Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by γ-irradiation. J. Immunol., 110, 1206
Miller, J. N., Whang, S. J. and Fazzan, F. P. (1963). Studies on immunity in experimental syphilis. I. Immunogenic response of rabbits immunized with Reiter protein antigen and challenged with virulent Treponema pallidum. Br. J. Vener. Dis., 39, 195
Mori, T., Kobayashi, H. and Nishimoto, H. et al. (1977). Inhibitory effect of progesterone and 20 alpha-hydroxypreg-4-en-3-one on the phytohemagglutinin-induced transformation of human lymphocytes. Am. J. Obstet. Gynecol., 127, 151
Morse, S. A. and Fitzgerald, T. J. (1974). Effect of progesterone on Neisseria gonorrhoeae. Infect. Immun., 10, 1370
Murr, S. M., Stabenfeldt, G. H. and Bradford, G. E. et al. (1974). Plasma progesterone during pregnancy in the mouse. Endocrinology, 94, 1209
Ng, A. B. P., Reagan, J. W. and Yen, S. S. C. (1970). Herpes genitalis: clinical and cytopathologic experience with 256 patients. Obstet. Gynecol., 36, 645
Novotny, P., Broughton, E. S. and Cownley, K. et al. (1978). Strain related infectivity of Neisseria gonorrhoeae for the guinea-pig subcutaneous chamber and the variability of the immune resistance in different breeds of guinea-pig. Br. J. Vener. Dis., 54, 88
Oriel, J. D., Partridge, B. M. and Denny, M. J. et al. (1972). Genital yeast infections. Br. Med. J., 4, 761
Overall, J. C., Jr., Kern, E. R. and Schlitzer, L. et al. (1975). Genital Herpesvirus hominis infection in mice. I. Development of an experimental model. Infect. Immun., 11, 476
Purtilo, D. T., Hallgren, H. M. and Yunis, E. J. (1972). Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet, 1, 769
Rank, R. G., White, H. J. and Houch, A. J., Jr. et al. (1982). Effect of estradiol on chlamydial genital infection of female guinea pigs. Infect. Immun., 38, 699
Romanoff, A. L. (1960). The Avian Embryo: Structural and Functional Development. ( New York: Macmillan )
Salt, I. E . (1982). The differential susceptibility of gonococcal opacity variants to sex hormones. Can. J. Microbiol., 28, 301
Smith, J. K., Caspary, E. A. and Field, E. J. (1972). Immune responses in pregnancy. Lancet, 1, 96
Streeter, P. R. and Corbeil, L. B. (1981). Gonococcal infection in endotoxin-resistant and endotoxin-susceptible mice. Infect. Immun., 32, 105
Yamai, S., Obara, Y., Nikkawa, T. et al. (1979). Preservation of Neisseria gonorrhoeae by the gelatin-disc method. Br. J. Vener. Dis., 55, 90
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Kita, E. (1985). Animal models for the study of human genital infection. In: Keith, L.G., Berger, G.S. (eds) Uncommon Infections and Special Topics. Infections in Reproductive Health, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4902-7_14
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DOI: https://doi.org/10.1007/978-94-009-4902-7_14
Publisher Name: Springer, Dordrecht
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