Abstract
During the almost 25 years since the introduction of LibriumR, the first benzodiazepine, benzodiazepines have become among the most widely used pharmaceutical substances in the history of medicine. These compounds have been of interest to me since they were first discovered, and I was responsible for some of the early clinical studies with LibriumR (Marks 1960a, 1960b). There is now a large number of benzodiazepines and some are antagonists rather than agonists to specific benzodiazepine receptors in the central nervous system (Braestrup & Squires, 1977; Moehler & Okada, 1977).
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References
Ayd F : Diazepam — the question of long-term therapy and withdrawal reactions. Drug Ther 1981;Special Supplement.
Balter MB, Levine J, Manheimer DI: Cross-national study of the extent of anti-anxiety/sedative drug use. N Engl J Med 1974;290:769–774.
Bass MJ: Do physicians overprescribe for women with emotional problems?Can Med Assoc J 1981; 125: 1211.
Bass MJ, Baskerville JC: Prescribing of minor tranquilizers for emotional problems in familv practice. Can Med Assoc J 1981; 125: 1225–1226.
Bergman U : Studies on patterns and prevalence of psychiatric drug use — data from the Nordic countries, in Tognoni G, et al. (eds):Epidemiological Impact of Psychotropic Drugs. Elsevier, North-Holland, Biomedical Press, 1981.
Blaha D, Brickmann J-V: Benzodiazepines in the treatment of anxiety (Angst): European experience, in Costa E (ed):The Benzodiazepines: From Molecular Biology to Clinical Practice. New York, Raven Press, 1983, pp 311–324.
Boethius G, Westerholm B: Is the use of hypnotics, sedatives and minor tranquilizers really a major health problem?Acta Med Scand 1976; 199: 507–512.
Bowden CL, Fisher JG: Safety and efficacy of long-term diazepam therapy. South Med J 1980; 73: 1581–1584.
Braestrup C, Squires RF: Brain specific benzodiazepine receptors in rat characterized by high affinity 3H-diazepam binding. Proc Natl Acad Sci 1977; 74: 3805–3809.
Breimer DD, Jochemsen R, Von Albert HH: Pharmacokinetics of benzodiazepines: short-acting versus long-acting. Arzneimittelforsch 1980; 30: 875–881.
Cohen S : Valium: its use and abuse. Drug Abuse Alcohol Newslt 1976;5:
Cooperstock R: Psychotropic drug use among women. Can Med Assoc J 1976; 115: 760–763.
Downing RW, Rickels K: Coffee consumption, cigarette smoking and reporting of drowsiness in anxious patients treated with benzodiazepines or placebo. Acta Psychiat Scand 1981; 64: 398–408.
Feely M, Calvert R, Gibson J: Clobazam in catamenial epilepsy. Lancet 1982; 2: 71–73.
Friedman GD, Siegelaub AB, Seltzer CC: Cigarettes, alcohol, coffee and peptic ulcer. N Engl J Med 1974; 290: 469–473.
Gilbert RM : Caffeine as a drug of abuse, in Gibbin RG, Israel Y, et al. (eds):Research Advances in Alcohol and Drug Problems. New York, John Wiley & Sons, 1976.
Greden JF: Anxiety or caffeinism: a diagnostic dilemma. Amer J Psychiatry 1974; 131: 1089–1094.
Greden JF, Procter A, Victor B: Caffeinism associated with greater use of other psychotropic agents. Compr Psychiatry 1981; 22: 565–571.
Greenblatt DJ, Shader RI: Clinical use of the benzodiazepines. Ration Drug Ther 1981; 15: 1–6.
Harding JW, Chrusciel TL: The use of psychotropic drugs in developing countries. Bull WHO 1975; 52: 359–367.
Harding JW, De Arango MV, Baltazar J, et al: Mental disorders in primary health care: a study of their frequency and diagnosis in four developing countries. Psychol Med 1980; 10: 231–241.
Hasday JD, Karch FE: Benzodiazepine prescribing in a family medical center. J Am Med Assoc 1981; 246: 1321–1325.
Hesbacher P, Stepansky P, Stepansky E, et al: Psychotropic drug use in family practice. Pharmakopsychiatrie Neuro-psychopharmakologie 1976; 9: 50–60.
Hollister LE: Valium: a discussion of current issues. Psychosomatics 1977; 18: 44–58.
Hollister LE, Motzenbecker FP, Degan RO: Withdrawal reactions from chlordiazepoxide (Librium). Psychopharmacologia 1961; 2: 63–68.
Idanpaan-Heikkila J:Studies in Drug Utilisation. WHO Regional Publications European Series No. 8. Copenhagen, WHO, 1979.
Koumjian K: The use of Valium as a form of social control. Soc Sci Med 1981; 15E: 245–249.
Lader MH: The present status of benzodiazepines in psychiatry and medicine. Arzneimittelforsch 1980; 30: 910–912.
Lapierre YD: Benzodiazepine withdrawal. Can J Psychiatry 1981; 26: 93–95.
Laporte J-R, Capella D, Gisbert R, et al: The utilization of sedative-hypnotic drugs in Spain, in Tognoni G, et al. (eds):Epidemiological impact of psychotropic drugs. Elsevier, North Holland, Biomedical Press, 1981.
Lunde PK, Baksaas I, Halse M, et al: Studies in Drug Utilisation. WHO Regional Publications European Series No. 8. Copenhagen, WHO, 1979.
Manheimer DI, Davidson ST, Balter MB: Popular attitudes and beliefs about tranquilizers. Am J Psychiatry 1973; 130: 1246–1253.
Marks J: Methaminodiazepoxide (Librium) — a new psychotropic drug. Chemother Rev 1960a; 1: 141–143.
Marks J: Tranquillizing drugs. Med Press 1960b; 244: 426–430.
Marks J :The Benzodiazepines: Use, Overuse, Misuse, Abuse? Lancaster, MTP Press, 1978.
Marks J: The benzodiazepines — use and abuse. Arzneimittelforsch 1980; 30: 898–901.
Marks J: Diazepam — the question of long-term therapy and withdrawal reactions. Drug Ther (Special Supplement) 1981.
Marks J: Measurement of the benefits of benzodiazepines, in Teeling-Smith G (ed):Measuring the Social Benefits of Medicine. London, Office of Health Economics, 1983a.
Marks J: Benzodiazepines — for good or evil. Neuropsychobiology 1983b; 10: 115–126.
McCranie EW: Alleged sex-role stereotyping in the assessment of women’s physical complaints: a study of general practitioners. Soc Sci Med 1978; 12: 111–115.
Mellinger GD: Use of licit drugs and other coping alternatives: some personal observations on the hazards of living, in Lettier DJ (ed):Drugs and Suicide — When Other Coping Strategies Fail. Beverly Hills, CA, Sage Publications, 1978.
Mellinger GD, Baiter MB: Prevalence and patterns of use of psychotherapeutic drugs: results from a 1979 national survey of American adults. Read before the International Seminar on the Epidemiological Impact of Psychotropic Drugs, Milan, June 24–26, 1981.
Mellinger GD, Balter MB, Manheimer DI, et al: Psychic distress, life crisis and the use of psychotherapeutic medications. Arch Gen Psychiatry 1978; 35: 1045–1052.
Moehler H, Okada T: Benzodiazepine receptor: demonstration in the central nervous system. Science 1977; 198: 849–851.
Moehler H, Okada T, Ulrich J, et al: Biochemical identification of the site of action of benzodiazepines in human brain by 3H-diazepam binding. Life Sci 1978; 22: 985–996.
Morrison AA: Regulatory control of the Canadian Government over the manufacture, distribution and prescribing of psychotropic drugs, in Cooperstock R (ed):Social Aspects of Psychotropic Drugs. Toronto, Alcohol and Drug Addiction Foundation, 1974, pp 9–19.
Nicholson AN, Marks J:Insomnia: A Guide for Medical Practitioners. Lancaster, MTP Press, 1983.
Parry HJ, Balter MB, Mellinger GD, et al: National patterns of psychotherapeutic drug use. Arch Gen Psychiatry 1973; 28: 869–784.
Petursson H, Lader MH: Withdrawal from long-term benzodiazepine treatment. Br Med J 1981; 283: 643–645.
Proctor RC: Prescription medication in the workplace. NC Med J 1981; 42: 5455–547.
Rickels K: Benzodiazepines in the treatment of anxiety: North American experience, in Costa E (ed):The Benzodiazepines: From Molecular Biology to Clinical Practice. New York, Raven Press, 1983, pp 295–310.
Roskies E: Sex, culture and illness — an overview. Soc Sci Med 1978; 12B: 139–144.
Smith DE, Wesson DR: Benzodiazepine dependency syndromes. J Psychoactive Drugs 1983; 15: 85–96.
Stika L, Kubat K, Elis J, et al: Studies on patterns and prevalence of psychotropic drug use (data from Czechoslovakia), in Tognoni G, et al. (eds):Epidemiological Impact of Psychotropic Drugs. Elsevier, North Holland, Biomedical Press, 1981.
Tallman JF, Paul SM, Skolnick P: Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science 1980; 207: 274–276.
Tessler R, Stokes R, Pietras M: Consumer response to Valium: a survey of attitudes and patterns of use. Drug Ther 1978; 8: 179–186.
Twaddle AC, Sweet RH: Characteristics and experiences of patients with preventable hospital admission. Soc Sci Med 1970; 4: 141–145.
Tyrer P, Rutherford D, Huggett T: Benzodiazepine withdrawal symptoms and propranolol. Lancet 1981; 1: 520–522.
Uhlenheth EH, Baiter MB, Lipman RS: Minor tranquillizers: clinical correlates of use in an urban population. Arch Gen Psychiatry 1978; 35: 650–655.
United Nations Convention on Psychotropic Substances, 1971. New York, United Nations, 1971.
Verbrugge LM : Complaints and diagnoses: sex differences in the vocabulary and attribution of illness. Read at the American Public Health Association Meeting, Los Angeles, 1978.
Williams P, Murray J, Clare A: A longitudinal study of psychotropic drug prescription. Psychol Med 1982;12:201–206.
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Marks, J. (1985). An International Overview. In: Smith, D.E., Wesson, D.R. (eds) The Benzodiazepines: Current Standards for Medical Practice. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4886-0_5
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DOI: https://doi.org/10.1007/978-94-009-4886-0_5
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