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Cytologic diagnosis of cervical infections

  • Chapter
Common Infections

Part of the book series: Infections in Reproductive Health ((IRHC,volume 1))

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Abstract

The cytologic features of cervical infections vary with the nature of the tissue lesion and the chronicity of the infective process; most commonly observed are nonspecific destruction of epithelial cell and inflammatory and immunologic reactions of the stromal layer. During physiological metaplasia the cervical epithelium appears inflamed and shows leukocytic infiltration. Bacteriologic studies of such lesions often yield disappointing results, with either the presence of nonpathogenic organisms or an absence of organisms (Singer and Jordan, 1976).

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References

  • Alitalo, K., Halila, H., Vesterinen, E. et al. (1982). Endo-and ectocervical human uterine epithelial cells distinguished by fibronectin production and keratinization in culture. Cancer Res., 42, 1142

    PubMed  CAS  Google Scholar 

  • Amstey, M. S., Patten, S. F. and Turk, M. (1973). Herpesvirus cervicitis and cervical neoplasia. Cancer, 32, 1321

    Article  PubMed  CAS  Google Scholar 

  • An, S. H. (1969). Herpes simplex virus infection detected on routine gynecologic cell specimens. Acta Cytol., 13, 354

    PubMed  CAS  Google Scholar 

  • Balduzzi, P. C., Nasello, M. A. and Amstey, M. S. (1972). Experimental infection of human cervix by herpesvirus type 2 in organ culture. Cancer Res., 32, 243

    PubMed  CAS  Google Scholar 

  • Blank, H., Burgoon, C. F., Baldridge, G. D. et al. (1951). Cytologic smears in diagnosis of herpes simplex, herpes zoster and varicella. J. Am. Med. Assoc., 146, 1410

    PubMed  CAS  Google Scholar 

  • Blank, H., Burgoon, C. F., Baldridge, G. D. et al. (1951). Cytologic smears in diagnosis of herpes simplex, herpes zoster and varicella. J. Am. Med. Assoc., 146, 1410

    PubMed  CAS  Google Scholar 

  • Blank, H., Burgoon, C. F., Baldridge, G. D. et al. (1951). Cytologic smears in diagnosis of herpes simplex, herpes zoster and varicella. J. Am. Med. Assoc., 146, 1410

    PubMed  CAS  Google Scholar 

  • Dillon, M. B., Rosenshein, N. B., Parmley, T. H. et al. (1981). The diagnosis and management of cervical intraepithelial neoplasia in the patient under the age of twenty-one. Int. J. Gynaecol. Obstet., 19, 97

    Article  PubMed  CAS  Google Scholar 

  • Diosi, P., Babusceac, L. and David, C. (1973). Distinctive cycopathic properties of cytomegalovirus recovered from the female genital tract. Am. J. Clin. Pathol., 59, 192

    PubMed  CAS  Google Scholar 

  • Diosi, P., Babusceac, L., Nevinglovschi, O. et al. (1967). Cytomegalovirus infection associated with pregnancy. Lancet, 2, 1063

    Article  PubMed  CAS  Google Scholar 

  • Dunlop, E. M. C., Jones, B. R. and Al-Hussaini, M. K. (1964). Genital infection in association with TRIC virus infection of the eye. III. Clinical and other findings. Preliminary Report. Br. J. Vener. Dis., 40, 33

    PubMed  CAS  Google Scholar 

  • Goodpasture, E. W. and Talbot, F. B. (1921). Concerning the nature of ‘protozoan-like’ cells in certain lesions of infancy. Am. J. Dis. Child., 21, 415

    Google Scholar 

  • Gupta, P. K. (1982). Intrauterine contraceptive devices: vaginal cytology, pathologic changes and clinical implications. Acta Cytol., 26, 571

    PubMed  CAS  Google Scholar 

  • Gupta, P. K., Hollander, D. H. and Frost, J. K. (1976). Actinomycetes in cervicovaginal smears: an association with IUD usage. Acta Cytol., 20, 295

    PubMed  CAS  Google Scholar 

  • Hager, W. D. and Majmudar, B. (1979). Pelvic actinomycosis in women using intrauterine contraceptive devices. Am. J. Obstet. Gynecol., 133, 60

    PubMed  CAS  Google Scholar 

  • Jeansson, S. and Molin, L. (1974). On the occurrence of genital herpes simplex infection: Clinical and virological findings and relation to gonorrhoea. Acta. Derm. Venereal., 54, 479

    CAS  Google Scholar 

  • Jesionek and Kiolemenoglou, (1904). Uber einen Befund von protozoen-artigen Gebilden in den Organen eines hereditar-letischen Fätus. Muench. Med. Wochenschr.,51, 1905

    Google Scholar 

  • Jindrâk, K. (1964). Die Zytomegalie in der Zervixschleimhaut einer Wöchnerin. Z. Allg. Pathol., 106, 255

    Google Scholar 

  • Jones, B. R., Collier, L. H. and Smith, C. H. (1959). Isolation of virus from inclusion blennorrhea. Lancet, 1, 902

    Article  PubMed  CAS  Google Scholar 

  • Jones, M. C., Buschmann, A. M., Dowling, L. A. et al. (1979). The prevalence of actinomyces-like organisms found in cervicovaginal smears of 300 IUD wearers. Acta Cytol., 23, 282

    PubMed  CAS  Google Scholar 

  • Jordan, M. C., Rousseau, W. E., Noble, G. R. et al. (1973). Association of cervical cytomegaloviruses with venereal disease. N. Engl. J. Med., 288, 932

    Article  PubMed  CAS  Google Scholar 

  • Kiviat, N., Paavonen, J., Brockway, J. et al. (1983). Diagnosis of C. Trachomatis Using Routine Papanicolaou Stained Cervical Smears. V international meeting of the International Society for STD research, Seattle

    Google Scholar 

  • Laverty, C. R., Russell, P., Black, J. et al. (1977). Adenovirus infection of the cervix. Acta Cytol., 21, 114

    PubMed  CAS  Google Scholar 

  • Lemon, S. H., Hutt, L. M., Shaw, J. E. et al. (1977). Replication of EBV in epithelial cells during infectious mononucleosis. Nature, 268, 268

    Article  PubMed  CAS  Google Scholar 

  • Meisels, A., Fortin, R. and Roy, M. (1977). Condylomatous lesions of the cervix. II. cytologic, colposcopic and histopathologic study. Acta Cytol., 21, 379

    PubMed  CAS  Google Scholar 

  • Morse, A. R., Coleman, D. V. and Gardner, S. D. (1974). An evaluation of cytology in the diagnosis of herpes simplex virus infection and cytomegalovirus infection of the cervix uteri. J. Obstet. Gynaecol. Br. Common w., 81, 393

    Article  CAS  Google Scholar 

  • Naib, Z. M. (1966). Exfoliative cytology of viral cervicovaginitis. Acta Cytol., 10, 126

    Google Scholar 

  • Naib, Z. M. (1970). Cytology of TRIC agent infection of the eye of newborn infants and their mothers genital tracts. Acta Cytol., 14, 390

    PubMed  CAS  Google Scholar 

  • Naib, Z. M., Nahmias, A. J. and Josey, W. E. (1966). Cytology and histopathology of cervical herpes simplex infection. Cancer, 19, 1026

    Article  PubMed  CAS  Google Scholar 

  • Ng, A. B. P., Reagan, J. W. and Yen, S. S. C. (1970). Herpes genitalis: Clinical and cytopathologic experience with 256 patients. Obstet. Gynecol., 36, 645

    PubMed  CAS  Google Scholar 

  • Nigogosyan, G. and Mills, J. W. (1965). Herpes simplex cervicitis. J. Am. Med. Assoc., 191, 152

    Google Scholar 

  • Numazaki, Y., Yano, N., Morizuka, T. et al. (1970). Primary infection with human cytomegalovirus: Virus isolation from healthy infants and pregnant women. Am. J. Epidemiol., 91, 410

    PubMed  CAS  Google Scholar 

  • Paavonen, J. and Purola, E. (1980). Cytologic findings in cervical chlamydial infection. Med. Biol., 58, 174

    PubMed  CAS  Google Scholar 

  • Paavonen, J., Vesterinen, E., Meyer, B. et al. (1982). Colposcopic and histological findings in cervical chlamydial infection. Obstet. Gynecol., 59, 712

    PubMed  CAS  Google Scholar 

  • Purola, E. and Savia, E. (1977). Cytology of gynecologic condyloma acuminatum. Acta Cytol., 21, 26

    PubMed  CAS  Google Scholar 

  • Purola, E., Halila, H. and Vesterinen, E. (1983). Condylomatous etiology of cervical dysplasia in adolescence. Gynecol. Oncol., 16, 34

    Article  PubMed  CAS  Google Scholar 

  • Rees, E., Tait, I. A., Hobson, D. et al. (1977). Chlamydia in relation to cervical infection and pelvic inflammatory disease. In Hobson, D. and Holmes, K. K. (eds.) Nongonococcal Urethritis and Related Infections, p. 67. ( Washington: American Society for Microbiology )

    Google Scholar 

  • Schachter, J. (1978). Chlamydial infections. N. Engl. J. Med., 298, 428

    Article  PubMed  CAS  Google Scholar 

  • Seppälä, M. and Vaheri, A. (1974). Natural rubella infection of the female genital tract. Lancet, 1, 46

    Article  PubMed  Google Scholar 

  • Singer, A. and Jordan, J. A. (1976). The anatomy of the cervix. In Jordan, J. A. and Singer, A. (eds.) The Cervix, p. 13. ( Philadelphia: W. B. Saunders )

    Google Scholar 

  • Sixbey, J. W., Vesterinen, E. H., Nedrud, J. G. et al. (1983). Replication of Epstein—Barr virus in human epithelial cells in vitro. Nature, 306, 480

    Article  PubMed  CAS  Google Scholar 

  • Stern, E. and Longo, L. D. (1963). Identification of herpes simplex virus in a case showing cytological features of viral vaginitis. Acta Cytol., 7, 295

    PubMed  CAS  Google Scholar 

  • Swanson, J., Eschenbach, D. A., Alexander, E. R. et al. (1975). Light and electron microscopic study of Chlamydia trachomatis infection of the uterine cervix. J. Infect. Dis., 131, 678

    Article  PubMed  CAS  Google Scholar 

  • Syrjänen, K. J. (1980). Current views on the condylomatous lesions in uterine cervix and their possible relationship to cervical squamous cell carcinoma. Obstet. Gynecol. Surv., 35, 685

    PubMed  Google Scholar 

  • Syrjänen, K., Heinonen, U. M. and Kauraniemi, T. (1981). Cytologic evidence of the association of condylomatous lesions with dysplastic and neoplastic changes in the uterine cervix. Acta Cytol., 25, 17

    PubMed  Google Scholar 

  • Vaheri, A., Vesikari, T., Oker-Blom, N. et al. (1972). Isolation of attenuated rubella vaccine virus from human products of conception and uterine cervix. N. Engl. J. Med., 286, 1071

    Article  PubMed  CAS  Google Scholar 

  • Varga, A. and Browell, B. (1960). Viral inclusion bodies in vaginal smears. Obstet. Gynecol., 16, 441

    PubMed  CAS  Google Scholar 

  • Vesterinen, E. (1976a). Herpes simplex and cytomegalovirus infections of the human uterine cervix. Dissertation, University of Helsinki, Helsinki

    Google Scholar 

  • Vesterinen. E. (1976b). Human ecto-and endocervical epithelial cells as targets for herpes simplex type two infection in vitro. Acta Pathol. Microbiol. Scand. (B), 84, 29

    CAS  Google Scholar 

  • Vesterinen, E., Carson, J., Walton. L. A. et al. (1986). Human ectocervical and endocervical epithelial cells in culture: a comparative ultrastructural study. Am. J. Obstet. Gynecol., 137, 681

    Google Scholar 

  • Vesterinen, E., Leinikki, P. and Saksela, E. (1975). Cytopathogenicity of cytomegalovirus to human ecto-and endocervical epithelial cells in vitro. Acta Cytol., 19, 473

    PubMed  CAS  Google Scholar 

  • Vesterinen, E.. Nedrud, J., Collier, A. et al. (1980a). Explantation and subculture of epithelial cells from human uterine ectocervix. Cancer Res., 40, 512

    PubMed  CAS  Google Scholar 

  • Vesterinen, E., Purola, E., Saksela, E. et al. (1977). Clinical and virological findings in patients with cytologically diagnosed gynecologic herpes simplex infections. Acta Cytol., 21, 199

    PubMed  CAS  Google Scholar 

  • Vesterinen, E., Vaheri, A., Paavonen, J. et al. (1978). Adenovirus infection and cytopathic alterations of human cervical epithelial cells in vitro. Acta Cytol., 22, 566

    PubMed  CAS  Google Scholar 

  • Wilbanks, G. D. and Campbell, J. A. (1972). Effect of herpes virus hominis type 2 on human cervical epithelium: Scanning electron microscopic observations. Am. J. Obstet. Gynecol., 112, 924

    PubMed  CAS  Google Scholar 

  • Wilbanks. G. D., Campbell, J. A. and Kaufman. L. A. (1970). Cellular changes of normal human cervical epithelium infected in vitro with herpes-virus hominis, type two (Herpes simplex). Acta Cytol., 14, 538

    PubMed  CAS  Google Scholar 

  • Wildy, P. (1971). Classification and nomenclature of viruses. In Melnick, J. L. (ed.) Monographs in Virology, vol. 5, p. 33. ( Basel: Karger )

    Google Scholar 

  • Wolinska, W. H. and Melamed, M. R. (1970). Herpes genitalis in women attending Planned Parenthood of New York City. Acta Cytol., 14, 239

    PubMed  CAS  Google Scholar 

  • Yen, S. S. C., Reagan, J. W. and Rosenthal, M. S. (1965). Herpes simplex infection in female genital tract. Obstet. Gynecol., 25, 479

    PubMed  CAS  Google Scholar 

  • Zur Hausen, H., de Villiers, E. and Gissman, L. (1981). Papillomavirus infections and human genital cancer. Gynecol. Oncol., 12, 124

    Article  Google Scholar 

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Authors
  1. E. Vesterinen
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  2. E. Purola
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  3. J. Paavonen
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois, USA

    Louis G. Keith MD, FACOG (Professor, Attending Obstetrician-Gynecologist) (Professor, Attending Obstetrician-Gynecologist)

  2. The Prentice Women’s Hospital and Medical Center of Northwestern, Memorial Hospital, Chicago, Illinois, USA

    Louis G. Keith MD, FACOG (Professor, Attending Obstetrician-Gynecologist) (Professor, Attending Obstetrician-Gynecologist)

  3. Department of Maternal and Child Health, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA

    Gary S. Berger MD, MSPH, FACOG (Director, Chapel Hill Fertility Services, and Adjunct Associate Professor) (Director, Chapel Hill Fertility Services, and Adjunct Associate Professor)

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© 1985 MTP Press Limited

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Vesterinen, E., Purola, E., Paavonen, J. (1985). Cytologic diagnosis of cervical infections. In: Keith, L.G., Berger, G.S. (eds) Common Infections. Infections in Reproductive Health, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4878-5_4

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  • DOI: https://doi.org/10.1007/978-94-009-4878-5_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8659-2

  • Online ISBN: 978-94-009-4878-5

  • eBook Packages: Springer Book Archive

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