Abstract
Contemporary neurochemical pathology has established that certain neurological conditions such as Parkinson’s disease, Huntingdon’s chorea, senile dementia of the Alzheimer type (SDAT) (see Rossor, 1981) and perhaps even Korsakoff’s syndrome (Mair & McEntee, 1983) are accompanied by changes in certain neurotransmitter systems of subcortical origin which innervate forebrain regions, including neocortex, hippocampus and the basal ganglia. These neurotransmitter systems include not only the major monoaminergic transmitter projections such as the coeruleo-cortical noradrenergic (NA) pathway, the mesotelencephalic dopamine (DA) projection, and the ascending 5-HT pathways from the raphe nuclei, but also those of the substituted nomoamine, acetylcholine (ACh), recently characterised as arising from the nucleus basalis of Meynert in the basal forebrain, which provides the neocortex with the bulk of its extrinsic cholinergic projection, and from the medial septum, innervating the hippocampus (see Figure 1).
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Robbins, T.W. (1986). Psychopharmacological and Neurobiological Aspects of the Energetics of Information Processing. In: Hockey, G.R.J., Gaillard, A.W.K., Coles, M.G.H. (eds) Energetics and Human Information Processing. NATO ASI Series, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4448-0_5
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