Abstract
African swine fever virus is morphologically like an iridovirus, but its DNA structure, the enzyme activities present in the virus particles and the host RNA polymerase II — independent RNA synthesis make African swine fever virus similar to poxvirus. The viral DNA ends show high-variability regions that could be related to the mechanism of virus evasion of the host immune system. A comparison of the binding properties of a panel of monoclonal antibodies to different African swine fever virus field isolates and to virus passaged in porcine macrophages have shown that the virus changes readily in most of the proteins recognized by the monoclonal antibodies.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Almendral, J. M., R. Blasco, V. Ley, A. Beloso, A. Talavera and E. Viñuela. 1984. Restriction site map of African swine fever virus DNA. Virology 133:258–270.
Breese, S. R., Jr. and C. J. DeBoer. 1966. Electron microscope observations of African swine fever virus in tissue culture cells. Virology 28:420–428.
Carrascosa, J. L., J. M. Carazo, A. L. Carrascosa, N. García, A. Santisteban and E. Viñuela. 1984. General morphology and capsid fine structure of African swine fever virus particles. Virology 132:160–172.
Carrascosa, A. L., M. del Val, J. F. Santaren and E. Viñuela. 1984. Purification and properties of African swine fever virus. J. Virol. 54:337–344.
DeBoer, C. J. 1967. Studies to determine neutralizing antibody in sera from animals recovered from African swine fever and laboratory animals inoculated with African virus with adjuvants. Arch. Ges. Virus Forsch. 20:164–179.
Enjuanes, L., A. L. Carrascosa and E. Viñuela. 1976. Isolation and properties of the DNA of African swine fever virus. J. Gen. Virol. 32:479–492.
Kuznar, J., M. L. Salas and L. Viñuela. 1980. DNA-dependent RNA polymerase in African swine fever virus. Virology 101:169–175.
Kuznar, J., M. L. Salas and E. Viñuela. 1981. Nucleoside triphosphate phosphohydrolase activities in African swine fever virus. Arch. Virol. 96:307–320.
Ortin, J., L. Enjuanes and E. Viñuela. 1979. Crosslinks in African swine fever virus DNA. J. Virol. 31:579–583.
Salas, M. L., J. Kuznar and E. Viñuela. 1981. Polyadenylation, methylation, and capping of the RNA synthesized in vitro by African swine fever virus. Virology 113:484–491.
Salas, M. L., J. Kuznar and E. Viñuela. 1983. Effect of rifamycin derivatives and coumermycin Al on in vitro RNA synthesis by African swine fever virus. Arch. Virol. 77:77–80.
Sanz, A., B. García-Barreno, M. L. Nogal, E. Viñuela and L. Enjuanes. 1985. Monoclonal anti-bodies specific for African swine fever virus DNA. Virology 56:199–206.
Sogo, J. M., J. M. Almendral, A. Talavera and E. Viñuela. 1984. Terminal and internal inverted repetitions in African swine fever virus DNA. Virology 113:271–275.
Viñuela, E. 1985. African swine fever virus. Curr. Top. Microbiol. Immunol. 116:151–170.
Wardley, R. C., C. de M. Andrade, D. N. Black, F. L. Castro Portugal, L. Enjuanes, W. R. Hess, C. Mebus, A. Ordas, D. Rutili, J. Sanchez Vizcaino, J. D. Vigario, P. J. Wilkinson, J. F. Moura Nunes and G. Thomson. 1983. African swine fever virus. Arch. Virol. 76:73–90.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Viñuela, E., Blasco, R., Agüero, M., García Barreno, B., Enjuanes, L. (1986). Genomic and antigenic variation of African swine fever virus. In: Augustine, P.C., Danforth, H.D., Bakst, M.R. (eds) Biotechnology for Solving Agricultural Problems. Beltsville Symposia in Agricultural Research, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4396-4_22
Download citation
DOI: https://doi.org/10.1007/978-94-009-4396-4_22
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8455-0
Online ISBN: 978-94-009-4396-4
eBook Packages: Springer Book Archive