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Relationship Between the Immune System and Cancer

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Book cover Immunotoxicology

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 16))

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Abstract

The notion that malignant cells may be subject to control by the immunological network of the host has been established conclusively by showing that the adoptive immune system can respond to experimentally induced animal tumours (1, 2). In these systems it has been shown that immunodepression leads to enhanced growth of tumors and/or to increased metastatic spread (3). Conversely, there is considerable evidence to show that immunotherapeutic manipulation can be used to suppress growth of local and/or metastatic tumors (4). The relevance of the findings with primary and syngeneically transplanted rodent tumors to human cancer remains unresolved. This is principally because of the lack of appropriate methods for defining human tumour antigens and detecting specific immune responses to them in cancer patients. Contemporary studies on tumor cell-lymphocyte interactions will probbably provide a more acceptable approach to this problem.

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Author information

Authors and Affiliations

  1. Cancer Research Campaign Laboratories, Nottingham, United Kingdom

    R. W. Baldwin

Authors
  1. R. W. Baldwin
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Editor information

Editors and Affiliations

  1. Commission of the European Communities, Luxembourg

    A. Berlin (Health and Safety Directorate) (Health and Safety Directorate)

  2. Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA

    J. Dean

  3. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland

    M. H. Draper  & E. M. B. Smith  & 

  4. Institute of Pharmacological Research “Mario Negri”, Milan, Italy

    F. Spreafico

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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg and WHO, Geneva

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Baldwin, R.W. (1987). Relationship Between the Immune System and Cancer. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_3

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  • DOI: https://doi.org/10.1007/978-94-009-4307-0_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8414-7

  • Online ISBN: 978-94-009-4307-0

  • eBook Packages: Springer Book Archive

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