Abstract
With the recognition that chemicals can have direct effect on the immune system the relatively new field of immunotoxicology is gaining wide support and interest, Gibson, Hubbard and Parke (1983). The objective of this article is to review some of our work on the immunotoxicology of asbestos and polybrominated biphenyls (PBB).
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Anderson, H.A.R., Lilis, R., Selikoff, I.J., Rosenman, K.D., Valciukas, J.A., & Freedman, S. (1978). Unanticipated prevalence of symptoms among dairy farmers in Michigan and Wisconsin. Environ. Health Perspect., 23: 217–226.
Bekesi, J.G., Holland, J.F., Anderson, H.A., Fischbein, A.S., Rom, W., Wolff, M.S., & Selikoff, I.J. (1978). Lymphocyte function of Michigan dairy farmers exposed to polybrominated biphenyls. Science 199: 1207–1209.
Bekesi, J.G., Roboz, J.P., Solomon, J., Fischbein, A., Roboz, J., & Selikoff, I.J. (1983). Persistent immune dysfunction in Michigan dairy farm residents exposed to polybrominated biphenyls. In Advances in Immunopharmacology, 2, (eds. Hadden, J.W., Chadid, L., Ducor, P., Spreafiro, S. and Willoughby, D. ) pp. 33–39. Pergamon Press, New York.
Bekesi, J.G. Roboz, J.P., Solomon, S., Fischbein, A.S. & Selikoff, I.J. (1983). Altered immune function in Michigan residents exposed to polybrominated biphenyls. In Immunotoxicology, (eds. Gibson, G.G., Hubbard, R. & Parke D.V. ) pp. 181–191. Academic Press, New York.
Carter, L.T. (1976). Michigan’s PBB incident: chemical mix-up leads to disaster. Science, 192; 240–243.
Dunckel, A.E. (1975). An updating on the polybrominated biphenyl disaster in Michigan. J. Amer. Vet. Med. Assoc., 167: 838–841.
Fischbein, A., Suzuki, Y. Selikoff, I.J. & Bekesi, J.G. (1978). Unexpected Longevity of a Patient with Malignant Pleural Mesothelioma. Cancer, 42: 1999–2004.
Gibson, G.G. Hubbard, R. & Parke, D.V. (1983). Immunotoxicology, pp. 1–505. Academic Press, New York.
Haslam, P.L., Luroszek, A. Merchant, J.A. & Turner-Warwick, M. (1978). Lymphocyte responses to phytohaemagglutinin in patients with asbestosis and pleural mesothelioma. Clin Exp Immunol., 31: 178–188.
Jackson, T.F. & Halbert, F.L. (1974). A toxic syndrome associated with the feeding of polybrominated biphenyls-contaminated concentrate to dairy cattle. J.Amer. Vet. Med. Assoc., 165: 437–439.
Kagan, E., Solomon, A., Cochrane, J.C., Kuba, P., Rocks, P.H. & Webster, I. (1977). Immunological studies of patients with asbestosis. II. Studies of circulating lymphoid cell numbers and humoral immunity. Clin Exp Immunol., 28: 208–275.
Kang, K.V., Sera, Y., Okochi, T. & Yamamura, Y., (1974). T lymphocytes in asbestosis. New Eng J Med., 291: 735–736.
Kay, K. (1977). Polybrominated,biphenyls (PBB) environmental contamination in Michigan, 1973–1976. Environ. Res., 13: 74–93.
Lange, A., Smolik, R., Chmielarczyk, W., Garncarek, D., & Gielgier, Z. (1978). Cellular immunity in asbestosis. Arch Immuno Ther Exp., 26: 899–903.
Lange, A., Smolik, R., Zatonski, W. & Szymanska, J. (1974). Autoantibodies and serum immunoglobulin levels in asbestos workers. Int Arch Arbeitmed, 32: 313–325.
Lilis, R., Anderson, H.A. Valciukas, J.A., Freedman, S. & Selikooff, I.J. (1978). Comparison of findings among residents on Michigan dairy farms and consumers of produce purchased from these farms. Environ. Health Perspect., 23: 105–109.
Matez, H., Lange, A., Garncarek, D., Smolik, R., Roszak, E. (1978). KLA and antinuclear antibody incidence in asbestos workers. Arch Immunol Ther Exp., 26: 201–205.
Roboz, J., Suzuki, R.K., Bekesi, J.G., Holland, J.F., Rosenman, K. & Selikoff, I.J. (1979). Mass spectral identification and quantification of polybrominated biphenyls in blood compartments of exposed Michigan chemical workers. J. Environ. Pathol. Toxicol., 3; 363–378.
Roboz, J., Greaves, J., Holland, J.F. & Bekesi, J.G. (1982). Determination of polybrominated biphenyls in serum by negative chemical ionization mass spectrometry. Anal. Chem., 54: 1104–1108.
Sundstrom, G., Huntzinger, 0. & Safe, S. (1976). Environmental chemistry of flame retardants. Part II. Identification of 2, 2’,4,4’, 5, 5’-hexabromobiphenyl as the major constituent of flame retardant Firemaster BP-6. Chemosphere, 5: 11–14.
Trosko, J.E., Davison, B. & Chang, C.C. (1981). PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: Its potential as a tumor promotor. Environ. Health Perspect., 37: 179–182.
Tsushimoto, G., Trosko, J.E., Change, C.C. & Aust. S.D. (1982). Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl ( PBB) congeners. Carcinogenesis, 3; 181–186.
Turner-Warwick, M.& Parkes, W.L. (1970). Circulating rheumatoid and antinuclear factors in asbestos workers. Br Med J., 3: 492–495.
Turner-Warwick, M. (1973). Immunologic mechanisms in occupational disorders. Immunolgy and asbestosis. Proc Roy Soc Mes., 66: 927–930.
Wagner, A.M., Campbell, M.J. & Edwards, R.E. (1979). Sequential immunological studies on an asbestos-exposed population. I. Factors affecting peripheral blood leukocytes and T lymphocytes. Clin exp. Immunol., 38: 323–331.
Wolff, M.S., Haymes, N., Anderson, H.A. & Selikoff, I.J. (1978). Family clustering of PBB and DDE values among Michigan dairy farmers.Environ. Health Perspect., 23: 315–319.
Wolff, M.S., Anderson, H.A., Camper, E., Nikaido, M.N., Daum, S.M., Haynes, N., Selikoff, I.J. & Aubrey, B. (1979a). Analysis of adipose tissue and serum from PBB (polybrominated biphenyl) exposed workers. J. Environ. Pathol. Toxicol., 2: 1397–1411.
Wolff, M.S., Anderson, H.A. & Selikoff, I.J. (1982). Human tissue burdens of halogenated aromatic chemicals in Michigan. J.Amer.Med. Assoc. 247; 2112–2116.
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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg and WHO, Geneva
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Bekesi, J.G., Roboz, J.P., Fischbein, A., Selikoff, I.J. (1987). Clinical Immunology Studies in Individuals Exposed to Environmental Chemicals. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_25
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DOI: https://doi.org/10.1007/978-94-009-4307-0_25
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