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Immunotoxicology pp 317–332Cite as

Immunotoxicological Effects of Asbestos

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Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 16))

Abstract

Exposure to asbestos dust may stimulate a severe reaction in the lungs leading to parechymal and pleural fibrosis. There is also an association between exposure to asbestos and the development of bronchogenic carcinomas and mesotheliomas. While the pathogenesis of these disorders is unknown, altered immunoregulatory mechanisms may be important and it also becomes increasingly important to know whether select individuals may react in an immunologically hyperactive way to inhalation of asbestos. This was recognized in 1973 when the Report of the Advisory Committee on Asbestos Cancer to the Director of the International Agency for Research on Cancer (Report 1973) recommended enquiring into the immunocompetence of asbestosis with regard to the role of immunity in the subsequent development of neoplasms. Since then there have been several clinical studies indicating definitive alterations in the immune profile of asbestos workers (Section I).

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Author information

Authors and Affiliations

  1. Immunotoxicology Department, The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey, SM5 4DS, UK

    Klara Miller

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  1. Klara Miller
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Editor information

Editors and Affiliations

  1. Commission of the European Communities, Luxembourg

    A. Berlin (Health and Safety Directorate) (Health and Safety Directorate)

  2. Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA

    J. Dean

  3. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland

    M. H. Draper  & E. M. B. Smith  & 

  4. Institute of Pharmacological Research “Mario Negri”, Milan, Italy

    F. Spreafico

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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg and WHO, Geneva

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Miller, K. (1987). Immunotoxicological Effects of Asbestos. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_23

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  • DOI: https://doi.org/10.1007/978-94-009-4307-0_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8414-7

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