Abstract
This report summarizes our experience over the past two years in selecting and validating methodology for the immunotoxicity assessment of chemicals. Methods to assess lesions of humoral or cell-mediated immunity, natural resistance and host susceptibility to tumor cell or bacterial challenge are described. A major focus of this report will be the limitations and utility of methods proposed, selection of appropriate controls; assay variation and indications for data transformation, a quality control program; correlations between altered immune function and susceptibility to bacterial or tumor cell challenge; the concept of a functional immune reserve and its estimation; and, the need for an international interlaboratory validation of methods.
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Dean, J.H., Lauer, L.D., House, R.V., Ward, E.C., Murray, M.J. (1987). Experience with Validation of Methodology for Immunotoxicity Assessment in Rodents. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_12
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DOI: https://doi.org/10.1007/978-94-009-4307-0_12
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