Skip to main content
SpringerLink
Log in

Biological Fate of Renal Agents

  • Chapter
Book cover Progress in Radiopharmacy

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 10))

  • 114 Accesses

Abstract

The kidney performs three essential functions: the excretory, the regulatory and the endocrine functions; this contributes to the complexity of anatomy and physiology of the human renal system. Non-invasive radionuclide procedures in the evaluation of renal diseases have been accepted increasingly as effective and valuable alternatives to older clinical methods: in fact “in vivo” nuclear medicine allows assessment of the three renal processes involved in the elaboration of urine: glomerular filtration, tubular reabsorption and tubular secretion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

General References

  • - Blaufox MD, Evaluation of renal function and disease with radionuclides. S. Karger, Basle, 1972.

    Google Scholar 

  • - Chervu LR, et al, Radiopharmaceuticals for renal studies. Sem. Nucl. Med. 4:3, 1974.

    Article  CAS  Google Scholar 

  • - Arnold RW, et al, Comparison of 99mTc complexes for renal imaging. J. Nucl. Med. 16:357, 1975.

    PubMed  CAS  Google Scholar 

  • - Jakubowski W, et al, Comparative investigations of renal scanning agents. Eur. J. Nucl. Med. 3:33, 1978.

    Article  PubMed  CAS  Google Scholar 

  • - Noronha OPD, et al, On the nature of technetium compounds. Eur. J. Nucl. Med. 6:121, 1980.

    Google Scholar 

  • - McAfee JG, et al, Comparison of renal extraction efficiencies for radioactive agents in the normal dog. J. Nucl. Med. 22:333, 1981.

    PubMed  CAS  Google Scholar 

  • - Cox PH, Technetium complexes for renal scintigraphy. In: Proc. in Radiopharmacology, Vol. 3, Cox PH, (ed), M. Nijhoff Publ., The Hague, 1982.

    Chapter  Google Scholar 

  • - Chervu LR, et al, Renal Radiopharmaceuticals: an update. Sem. Nucl. Med. 12:224, 1982.

    Article  CAS  Google Scholar 

  • - Dubovsky EV, et al, Quantitation of renal function with glomerular and tubular agents. Sem. Nucl. Med. 12:308, 1982.

    Article  CAS  Google Scholar 

  • - Taylor A, et al, Differential renal function in unilateral renal injury: possible effects of radiopharmaceutical choice. J. Nucl. Med. 26:77, 1985.

    PubMed  CAS  Google Scholar 

References for GRF

  • - McChesney EW, et al, Studies of the tissue distribution and excretion of sodium diatrizoate in laboratory animals. Amer. J. Roentgenol. 78:137, 1957.

    PubMed  CAS  Google Scholar 

  • - Winter CC, et al, Three new test agents for the radioisotope renogram: DISA-I131; EDTA-Cr51; and Hippuran-I125. J. Nucl. Med. 3:273, 1962.

    PubMed  CAS  Google Scholar 

  • - Blaufox MD, et al, Plasmatic diatrozoate-I131 disappearance and glomerular filtration in the dog. Amer. J. Physiol. 204:536, 1963.

    PubMed  CAS  Google Scholar 

  • - Griep RJ, et al, Mechanisms of excretion of radioiodinated sodium iothalamate. Radiology 93:807, 1969.

    CAS  Google Scholar 

  • - Hauser W, et al, Technetium-99m DTPA: A new radiopharmaceutical for brain and kidney scanning. Radiology 94:679, 1970.

    PubMed  CAS  Google Scholar 

  • - Klopper FJ, et al, Evaluation of 99mTc-DTPA for the measurement of glomerular filtration rate. J. Nucl. Med. 13:107, 1972.

    PubMed  CAS  Google Scholar 

  • - Reba RC, et al, Radiolabeled chelates for visualization of kidney function and structure with emphasis on their use in renal insufficiency. Sem. Nucl. Med. 4:151, 1974.

    Article  CAS  Google Scholar 

  • - Agha N, et al, Comparative labelling on biokinetic studies of 99mTc-EDTA (Sn) and 99mTc-DTPA(Sn). Nucl. Med. 16:30, 1977.

    CAS  Google Scholar 

  • - Saha BG, et al, Measurement of renal function with 111In-DTPA in dogs. Int. J. Nucl. Med. Biol. 4:99, 1977.

    Article  CAS  Google Scholar 

  • - Johansson RS, et al, 113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). Eur. J. Nucl. Med. 3:179, 1978.

    Article  PubMed  CAS  Google Scholar 

  • - McAfee JG, et al, Biological distribution and excretion of DTPA labelled with Tc-99m and In-111. J. Nucl. Med. 20:1273, 1979.

    PubMed  CAS  Google Scholar 

  • - Carlsen JE, et al, Comparison of four commercial Tc-99m(Sn) DTPA preparations used for the measurement of glomerular filtration rate: Concise communication. J. Nucl. Med. 21:126, 1980.

    PubMed  CAS  Google Scholar 

  • - Swick M, Excretion urography by means of the intravenous and oral administration of sodium ortho-iodohippurate with some physiological considerations. Surg. Gynec. Obstet. 56:62, 1983.

    Google Scholar 

  • - Konilowski T, et al, Renal clearance in mice as a bioassay for radiopharmaceuticals: Intercomparison of commercial sources of iodohippurate sodium 131I(OIH). Int. J. Nucl. Med. Biol. 1:37, 1973.

    Article  Google Scholar 

  • - Assailly J, et al, Noninvasive experimental determination of the individual kidney filtration fraction by means of a dual-tracer technique. J. Nucl. Med. 18:684, 1977.

    PubMed  CAS  Google Scholar 

  • - Bögl W, et al, Chemische Form der radioaktiven Ausscheidungsprodukte nach intravenöser Verabreichung von 125J-Orthojodhippuran an Ratten. Nucl. Med. 17,2:53, 1978.

    Google Scholar 

  • - Stadalnik RC, et al, Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH. J. Nucl. Med. 21:168, 1980.

    PubMed  CAS  Google Scholar 

  • - Kaspersen FM, et al, Radioiodinated o-iodobenzoic acid as impurity in hippuran preparations. Int. J. appl. Radiat. Isot. 31:97, 1979.

    Article  Google Scholar 

  • - Fritzberg AR, et al, Biodistribution and renal excretion of 99mTcN,N′-bis-(Mercaptoacetamido) ethylenediamine. Effect of renal tubular transport inhibitors. Int. J. Nucl. Med. Biol. 9:79, 1982.

    Article  PubMed  CAS  Google Scholar 

  • - Fritzberg AR, et al, Chemical and biological studies of Tc-99m (N,N′-Bis (Mercaptoacetamido)-ethylenediamine): A potential replacement for I-131 iodohippurate. J. Nucl. Med. 22:258, 1981.

    PubMed  CAS  Google Scholar 

  • - Klingensmith WC, et al, Clinical comparison of Tc-99m (N,N′-Bis(Mercaptoacetamido) ethylenediamine) and 131I ortho-iodohippurate for evaluation of renal tubular function. J. Nucl. Med. 23:377, 1982.

    PubMed  Google Scholar 

  • - Ogiunski M, et al, Comparative evaluation of renoscintigraphic properties and plasma clearance of (99mTc-DADS (99mTc-N,N′-Bis/-Mercaptoacetamido ethylenediamine), 99mTc-DTPA and 131I-o-hippuran. Nucl. Med. 22:136, 1983.

    Google Scholar 

  • - Subramanian G, et al, Structure distribution relationship in the design of Tc-99m radiopharmaceuticals. In: Safety and efficacy of Radiopharmaceuticals. Kristensen K, Norbygaard W, (eds), M. Nijhoff, Publ., The Hague, 1984.

    Google Scholar 

  • - Klingensmith WC, et al, Clinical evaluation of Tc-99m N,N′-Bis (Mercaptoacetyl)-2,3-diaminopropanate as a replacement for I-131 hippurate. J. Nucl. Med. 24:42, 1984.

    Google Scholar 

  • - Chervu LR, et al, Technetium-99m-labeled P-aminohippuric acid analog: A new renal agent. J. Nucl. Med. 25:1111, 1984.

    PubMed  CAS  Google Scholar 

References for Kidney Morphology

  • - Kloss G, Strahlehbelastung durch Hg203-markierte Testpräparate zur Nierendiagnostik. Nucl. Med. III,1:82, 1962.

    Google Scholar 

  • - Jovanovic V, et al, Biological and chemical properties of 197Hg chlormerodrin. Nucl. Med. 12:335, 1973.

    Google Scholar 

  • - Pedroso De Lima JJ, et al, Die renale Szintigraphie mit 131J-trasylol. Nucl. Med. 12:26, 1973.

    CAS  Google Scholar 

  • - Lin TH, et al, A 99mTc-chelate substitute for organoradiomercurial renal agents. J. Nucl. Med. 15:34, 1974.

    PubMed  CAS  Google Scholar 

  • - Berkes I, et al, The synthesis and chemical properties of 3-chloromercury-2-hydroxipropyl-urea. Nucl. Med. 14:374, 1975.

    CAS  Google Scholar 

  • - MIRD, Summary of current radiation dose estimates to humans from 197Hg- and 203Hg-labeled chlormerodrin. J. Nucl. Med. 16:1095, 1975.

    Google Scholar 

  • - Vanlic-Razumenic NM, et al, Studies of chemical and biological properties of 99mTc-DNS (dimercaptosuccinic acid) — renal imaging agent. Eur. J. Nucl. Med. 1:235, 1976.

    Article  PubMed  CAS  Google Scholar 

  • - Ikeda I, et al, Chemical and biological studies on 99mTc-DMS-I: Formation of complexes by four different methods. Int. J. Nucl. Med. Biol. 4:56, 1977.

    Article  PubMed  CAS  Google Scholar 

  • - Ikeda I, et al, Preparation of various Tc-99m dimercaptosuccinate complexes and their evaluation as radiotracers. J. Nucl. Med. 18:1222, 1977.

    PubMed  CAS  Google Scholar 

  • - Daly MJ, et al, Differential renal function using technetium-99m dimercaptosuccinic acid (DMSA): In vitro correlation. J. Nucl. Med. 20:63, 1979.

    PubMed  CAS  Google Scholar 

  • - Kubiatowicz DO, et al, Localization of low molecular weight 99mTc-labeled dimercaptodicarboxylic acids in kidney tissue. J. Pharm. Sci. 68:621, 1979.

    Article  PubMed  CAS  Google Scholar 

  • - Taylor A, et al, Optimal handling of dimercaptosuccinic acid for quantitative renal scanning. J. Nucl. Med. 21:1190, 1980.

    PubMed  CAS  Google Scholar 

  • - Vanlic-Razumenic N, et al, Biochemical studies of the renal radiopharmaceutical compound dimercaptosuccinate. I. Subcellular localization of 99mTc-DMS complex in the rat kidney in vivo. Eur. J. Nucl. Med. 6:169, 1981.

    Article  PubMed  CAS  Google Scholar 

  • II. Subcellular localization of 99mTc-DMS complex in the rat kidney in vivo. Eur. J. Nucl. Med. 7:304, 1982.

    Article  PubMed  CAS  Google Scholar 

  • III. Subcellular distribution and interaction of 99mTc-DMS complex with macromolecules in rat kidney homogenates in vitro. Eur. J. Nucl. Med. 7:308, 1982.

    Article  PubMed  Google Scholar 

  • - Vanlic-Razumenic N, Comparative examinations of 99mTc-DMS preparations obtained by labelling dimercaptosuccinate kits with different formulations. Nucl. Med. 20:46, 1981.

    CAS  Google Scholar 

  • - Yee CA, et al, 99mTc-DMSA renal uptake: Influence of biochemical and physiologic factors. J. Nucl. Med. 22:1054, 1981.

    PubMed  CAS  Google Scholar 

  • - Bianchi C, et al, Aprotinin 99mTc: A new tracer for the study of kidney morphology and function. In: Secondary forms of hypertension. Current diagnosis and management. Blaufox MD, (ed), Grune and Stratton, New York, pp 289–308, 1981.

    Google Scholar 

  • - Bianchi C, et al, 99mTc-aprotinin; a low molecular weight protein for the study of renal function. In: Radioaktive Isotope in Klinik und Forschung. Gasteiner Int. Symp. pp 315–321, 1981.

    Google Scholar 

  • - Bianchi C, et al, Aprotinin 99mTc: A new tracer for kidney imaging and unilateral renal function studies. Proc. 3rd World Congr. Nucl. Med. Biol. pp 2756–2760, 1982.

    Google Scholar 

  • - Taylor A, Quantitation of renal function with static imaging agents. Sem. Nucl. Med. 12:330, 1982.

    Article  Google Scholar 

  • - Vanlic-Razumenic N, et al, In vivo localization of chlormerodrin-203Hg in rat kidney as determined by cell fractionation method. Strahlentherapie 159:28, 1983.

    PubMed  CAS  Google Scholar 

  • - Aprile C, et al, 99mTc-aprotinin: Comparison with 99mTc-DMSA in normal and diseased kidneys. Nuklearmedizin 23:22, 1984.

    PubMed  CAS  Google Scholar 

  • - Moretti JL, et al, 2,3-dimercaptosuccini-acid chelates — II Renal Localization. Int. J. Nucl. Med. Biol. 11:275, 1984.

    Article  PubMed  CAS  Google Scholar 

References on Mixed Compounds

  • - De Filippi PG, et al, 99mTc-gluconate complex for kidney scanning. J. Nucl. Biol. Med. 19:58, 1975.

    PubMed  Google Scholar 

  • - Hambright P, et al, Chemistry of technetium radiopharmaceuticals. I. Exploration of the tissue distribution and oxidation state consequences of technetium (IV) in Tc-Sn-gluconate and Tc-Sn-EHDP using carrier 99mTc. J. Nucl. Med. 16:478, 1976.

    Google Scholar 

  • - Vanlic-Razumenic N, et al, Comparative chemical, biological and clinical studies of 99mTc-glucoheptonate and 99mTc-dimercaptosuccinate as used in renal scintigraphy. Nucl. Med. 18:40, 1979.

    CAS  Google Scholar 

  • - Agha NH, et al, Instant 99mTc-labelled glucoheptonate kit for kidney imaging. Nucl. Med. 22:246, 1983.

    CAS  Google Scholar 

Download references

Authors
  1. M. Villa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Saccavini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Bardy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Rotterdamsch Radiotherapeutisch Instituut, Rotterdam, The Netherlands

    P. H. Cox

  2. Regional Centre for Radiotherapy Department of Oncology and Nuclear Medicine, Essex County Hospital, Colchester, UK

    S. J. Mather

  3. Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, UK

    C. B. Sampson

  4. Department of Nuclear Medicine, Guy’s Hospital, London, UK

    C. R. Lazarus

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Villa, M., Saccavini, J.C., Bardy, A. (1986). Biological Fate of Renal Agents. In: Cox, P.H., Mather, S.J., Sampson, C.B., Lazarus, C.R. (eds) Progress in Radiopharmacy. Developments in Nuclear Medicine, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4297-4_21

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4297-4_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8410-9

  • Online ISBN: 978-94-009-4297-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation