Skip to main content

Indium Chemistry in Radiopharmaceutical Development

  • Chapter
Book cover Progress in Radiopharmacy

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 10))

Abstract

Two isotopes of Indium have found widespread use in nuclear medicine, In111 and In113m.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kramer HH, Stern HS, Indium-113m as a scanning agent. J. Nucl. Med. 7:365, 1966.

    Google Scholar 

  2. Liburdy RP, Hunter D, Want AR, Tatsch RE, Indium-114 as dual nuclide studies with Cr-51:comparison with In-111. J. Nucl. Med. 21:992, 1980.

    PubMed  CAS  Google Scholar 

  3. Ehrhardt GJ, Volkert W, Goeckler WF, Kapsch DN, A new Cd-115 → In-115m radionuclide generator. J. Nucl. Med. 24:349, 1983.

    PubMed  CAS  Google Scholar 

  4. McAfee JG, Subramanian G, Gagne G, Technique of leukocyte harvesting and labelling: problems and perspectives. Sem. Nucl. Med. 14:83, 1984.

    Article  CAS  Google Scholar 

  5. Carrasquillo JA, Krohn KA, Beaumier P, McGuffin RW, Brown JP, Hellstrom KE, Hellstrom I, Larson SM, Diagnosis and therapy for solid tumours with radiolabelled antibodies and immune fragments. Cancer Meat. Rep. 68:317, 1984.

    CAS  Google Scholar 

  6. Khaw BA, Fallon JT, Strauss HW, Haber E, Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111 — diethylenetriamine pentaacetic acid. Science 209:295, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. Goldenberg DM, Deland F, Euishin K, Bennett S, Primus FJ, Van Nagell JR, Estes N, DeSimone P, Rayburn P, Use of radiolabelled antibodies to carcinoembryonic antigen for the detection and localisation of diverse cancers by external photoscanning. New Engl. J. Med. 298:1384, 1978.

    Article  PubMed  CAS  Google Scholar 

  8. Mach JP, Forni M, Ritschard J, Buchegger F, Carrell S, Widgren S, Donath A, Alberto P, Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas. (In print).

    Google Scholar 

  9. Fairweather DS, Bradwell AR, Dykes PW, Vaughan AT, Watsom-James SF, Chandler S, Improved tumour localisation using indium-111 labelled anti-bodies. Brit. med. J. 287:167, 1983.

    Article  CAS  Google Scholar 

  10. Rainsbury RM, The localisation of human breast carcinomas by radiolabelled monoclonal antibodies. Brit. J. Surg. 71:805, 1984.

    Article  PubMed  CAS  Google Scholar 

  11. Contreras JG, Tuck DG, Coordination compounds of indium XXIII. Adducts of cyclopentadienyl indium (I) with boron trihalides or trimethylboron. Inorg. Chem. 12:2596, 1973.

    Article  CAS  Google Scholar 

  12. Carthy AJ, Tuck DG, The coordination of chemistry of indium. Prog. Inorg. Chem. 19:243, 1975.

    Article  Google Scholar 

  13. Visco RE, Indous ion-intermediate in the electrochemical oxidation of In metal. J. Electrochem. Soc. 112:932, 1965.

    Article  CAS  Google Scholar 

  14. Anbar M, Reactions of hydrated electrons with inorganic compounds. Quart. Rev. 22:578, 1968.

    Article  CAS  Google Scholar 

  15. Tuck DG, Critical survey of stability constants of complexes of indium. Pure Appl. Chem. 55:1477, 1983.

    Article  CAS  Google Scholar 

  16. Kraus KA, Nelson F, Smith GW, Anion exchange studies (IX) absorbability of a number of metals in HCl solution. J. Phys. Chem. 58:11, 1954.

    Article  CAS  Google Scholar 

  17. Semkow T, Wahl AC, Extraction of Ag(I), Cd(II), In(III), Sn(II), Sn(IV), Sb(III) and U(VI) from aqueous solutions by ketone solutions using single step batch and continuous SISAK method. J. Radioanal. Chem. 79: 93, 1983.

    Article  CAS  Google Scholar 

  18. Kasta L, Hoste J, Separation of microamounts of indium from zinc. Mikrochim. Acta 416:790, 1956.

    Article  Google Scholar 

  19. Hudgens JE, Nelson LC, Determinations of small concentrations of indium by radioactivation. Ann. Chem. 24:1472, 1952.

    Article  CAS  Google Scholar 

  20. Sunderman DN, Townley CW, The radiochemistry of indium. NAS. Nat. Res. Council, Nuclear Science Series, NAS-NS 3014, 1960.

    Google Scholar 

  21. Legendre JM, The influence of pH and the binding anion of the interaction In3+-transferrin — study of perturbed angular correlation spectroscopy on the 172 and 245 Key rays of In-111. Biochemie 66:429, 1984.

    Article  CAS  Google Scholar 

  22. Pandian S, Mathias CJ, Welch MJ, Perturbed angular correlation studies of In-111 labelled platelets. Int. J. appl. Radiat. Isot. 33:33, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Wyeth P, Personal communication.

    Google Scholar 

  24. Aplin JP, Wriston JR, Preparation, properties and applications of carbohydrate conjugates of proteins and lipids. CRC Crit. Rev. Biochem. 10:259, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Meares CF, DeRimmer LH, Leung CSH, Yeh SM, Miura M, Sherman DG, Properties in vivo of chelate tagged proteins and polypeptides. Adv. Chem. Ser. 198:369, 1982.

    Article  CAS  Google Scholar 

  26. Doherty PW, Hnatowich D, Yttrium-90 labelled monoclonal antibody of a potential agent for radioimmunotherapy. J. Nucl. Med. 25:111, 1984.

    Google Scholar 

  27. Krejcarek GE, Tucker KL, Covalent attachment of chelating groups to macromolecules. Biochem. biophys. Res. Commun. 77:581, 1977.

    Article  PubMed  CAS  Google Scholar 

  28. Eckelman WC, Karesh SM, Reba RC, New compounds: Fatty acid and long chain hydrocarbon derivatives containing a strong chelating agent. J. Pharm. Sci. 64:704, 1975.

    Article  PubMed  CAS  Google Scholar 

  29. Buckley RG, Searle F, An efficient method for labelling antibodies with III-In. FEBS Letters 166:202, 1984.

    Article  PubMed  CAS  Google Scholar 

  30. Hnatowich DJ, Layne WW, Childs RK, The preparation and labelling of DTPA-coupled albumin. Int. J. appl. Radiat. Isot. 33:327, 1982.

    Article  PubMed  CAS  Google Scholar 

  31. Hnatowich DJ, Layne WW, Childs RL, Lanteigne D, David MA, Griffin TW, Doherty PW, Radioactive labelling of antibody: A simple and efficient method. Science 220:613, 1983.

    Article  PubMed  CAS  Google Scholar 

  32. Gansow OA, Atcher RW, Link DC, Variables influencing the attachment of bifunctional chelates to antibodies. J. Nucl. Med. 22:56, 1984.

    Google Scholar 

  33. Paik CH, Murphy PR, Eckelman WC, Volkert WA, Reba RC, Optimisation of the DTPA mixed anhydride reaction with antibodies at low concentration. J. Nucl. Med. 24:932, 1983.

    PubMed  CAS  Google Scholar 

  34. Yeh SM, Meares CF, Goodwin DA, Decomposition rates of radiopharmaceutical indium chelates in serum. J. Radioanal. Chem. 53:327, 1979.

    Article  CAS  Google Scholar 

  35. Meares CF, McCall MJ, Reardan DT, Goodwin DA, Diamanti CI, McTigue M, Conjugation of antibodies with bifunctional chelating agents; isothiocyanate and bromoacetamide reagents, method of analysis and subsequent addition of metal ions. Ann. Biochem. 142, 1984.

    Google Scholar 

  36. Sundberg MW, Meares CF, Goodwin DA, Diamanti CI, Chelating agents for the binding of metal ions to macromolecules. Nature 250:587, 1974.

    Article  PubMed  CAS  Google Scholar 

  37. Meares CF, Goodwin DA, Leung C, Girgis AY, Silvester DJ, Nunn AD, Lavender PJ, Covalent attachment of metal chelates to proteins: the stability in vivo and in vitro of a conjugate of albumin with a chelate of 111-In. Proc. nat. Acad. Sci. USA, 73:3803, 1976.

    Article  PubMed  CAS  Google Scholar 

  38. Crighton RR, Roman F, Roland F, Iron mobilisation from ferritin by chelating agents. J. Inorg. Biochem. 13:305, 1980.

    Article  Google Scholar 

  39. Pollack S, Vanderhoff G, Lasky F, Iron removal from transferrin. An experimental study. Biochim. biophys. Acta. 497:481, 1977.

    PubMed  CAS  Google Scholar 

  40. Gokcy A, Nakamura RM, Tubis M, Wolf W, Synthesis of indium labelled antibody-chelate conjugates for radioassays. Int. J. Nucl. Med. Biol. 9:85, 1982.

    Article  Google Scholar 

  41. Yokohama A, Ohmomo Y, Horiuchi K, Saji H, Tanaka H, Yamamoto K, Ischii Y, Torizuka K, Deferoxamine, a promising bifunctional chelating agent for labelling proteins with gallium, Ga-67, DF-HSA: concise communication. J. Nucl. Med. 23:909, 1982.

    Google Scholar 

  42. Wang TST, Rosen JM, Smith R, Fawwaz RA, Ferrone S, Alderson PO, A new approach to bifunctional chelate attachment to antibodies. J. Nucl. Med. 25:56, 1984.

    Google Scholar 

  43. Moerlein SM, Welch MJ, Raymond KN, Weitl FL, Tricatecholamide analogues of enterobactin as gallium- or indium-binding radiopharmaceuticals. J. Nucl. Med. 22:710, 1981.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Harrison, R.C. (1986). Indium Chemistry in Radiopharmaceutical Development. In: Cox, P.H., Mather, S.J., Sampson, C.B., Lazarus, C.R. (eds) Progress in Radiopharmacy. Developments in Nuclear Medicine, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4297-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4297-4_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8410-9

  • Online ISBN: 978-94-009-4297-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics